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LRRK2 Gene PARK8 Parkinson NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

LRRK2 Gene PARK8 Parkinson NGS Genetic Test

Short Name: LRRK2 Gene NGS Test

Also known as: PARK8 Genetic Test, LRRK2 Mutation Analysis, Leucine-Rich Repeat Kinase 2 Gene Test, LRRK2 Sequencing Test, Parkinson's Disease Genetic Panel LRRK2

LRRK2 Gene PARK8 Parkinson NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Bioinformatics Analysis, Sanger Confirmation (if required) on Blood or Extracted DNA or One Drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from sample receipt at the laboratory. The report includes detailed findings on LRRK2 gene sequencing, variant classification, clinical interpretation, and recommendations. Raw data, FASTQ files, and VCF files are also provided alongside the clinical report.. Free home collection in 300+ cities across India.

Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The primary purpose of the LRRK2 Gene PARK8 Parkinson NGS Genetic Test is to identify pathogenic or likely pathogenic mutations in the LRRK2 gene that are associated with an increased risk of developing Parkinson's disease. This test aids in confirming a genetic etiology for Parkinsonian symptoms, assists in differential diagnosis, enables risk assessment for family members through cascade testing, and supports informed clinical management and eligibility for targeted clinical trials.

Test Code
1790
ICD Code
G20
Price
₹20,000
Sample Type
Blood or Extracted DNA or One Drop Blood on FTA Card
Result Time
Results are typically available within 3 to 4 weeks from sample receipt at the laboratory. The report includes detailed findings on LRRK2 gene sequencing, variant classification, clinical interpretation, and recommendations. Raw data, FASTQ files, and VCF files are also provided alongside the clinical report.
Fasting Required
No
Method
Next-Generation Sequencing (NGS), Bioinformatics Analysis, Sanger Confirmation (if required)
Step 1

Sample Collection

A genetic counseling session is recommended before sample collection to discuss the implications of testing, obtain informed consent, and construct a detailed family pedigree. No fasting is required. Provide complete clinical history of the patient including age of onset, symptoms, family history, and any previous genetic test results.

Method: Venipuncture / FTA Card Blood Spot

Step 2

Laboratory Analysis

A trained phlebotomist will collect 3-5 mL of peripheral venous blood in an EDTA (lavender-top) tube using standard venipuncture technique. Alternatively, one drop of blood can be applied to an FTA card. The collection procedure typically takes 5-10 minutes.

Step 3

Report Delivery

Apply gentle pressure and a cotton ball or bandage to the puncture site. No special post-collection precautions are necessary. The sample will be transported to the laboratory under controlled ambient temperature conditions. Results will be available in 3-4 weeks via online portal, email, or WhatsApp.

Timeline: Results are typically available within 3 to 4 weeks from sample receipt at the laboratory. The report includes detailed findings on LRRK2 gene sequencing, variant classification, clinical interpretation, and recommendations. Raw data, FASTQ files, and VCF files are also provided alongside the clinical report.

Patient Instructions

1
Before the Test:A genetic counseling session is recommended before testing to discuss the implications of results, review the family pedigree, and obtain informed consent. No fasting is required. Provide your complete clinical history, including onset of symptoms, current medications, and any prior genetic test results. Discuss with your neurologist whether this test is appropriate for your clinical situation.
2
During the Test:A trained phlebotomist or healthcare professional will collect a blood sample (3-5 mL in an EDTA tube) or a blood spot on an FTA card through a simple venipuncture procedure. The process takes approximately 5-10 minutes. You may feel a brief pinch or mild discomfort at the needle insertion site. The sample is then sent to the NABL-accredited laboratory for NGS analysis.
3
After the Test:After sample collection, apply gentle pressure to the puncture site with a cotton ball or bandage. No special post-test precautions are necessary. You can resume normal activities immediately. Results will be delivered within 3 to 4 weeks through the online portal, email, or WhatsApp. A genetic counseling session is recommended after receiving results to properly understand findings and discuss next steps.

About This Test

Who Should Get This Test

The primary purpose of the LRRK2 Gene PARK8 Parkinson NGS Genetic Test is to identify pathogenic or likely pathogenic mutations in the LRRK2 gene that are associated with an increased risk of developing Parkinson's disease. This test aids in confirming a genetic etiology for Parkinsonian symptoms, assists in differential diagnosis, enables risk assessment for family members through cascade testing, and supports informed clinical management and eligibility for targeted clinical trials.

How to Prepare

  • Collect 3-5 mL peripheral venous blood in an EDTA (Lavender Top) tube
  • Alternatively, apply one drop of blood to an FTA card and allow to dry completely
  • Label the sample with the patient's full name, date of birth, unique ID, and date of collection
  • Ensure the tube is gently inverted 8-10 times after collection to prevent clotting
  • Transport the sample at ambient room temperature (15-25°C)
  • Include the completed test requisition form and clinical history
  • Ship to the laboratory within 48 hours of collection

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"As a neurologist, I find the LRRK2 genetic test invaluable for patients with a family history of Parkinson's disease or those presenting with early-onset symptoms. Identifying LRRK2 mutations not only confirms the genetic basis of the condition but also helps in family risk assessment and may open doors to targeted therapies currently under clinical investigation. I recommend this test as part of a comprehensive diagnostic workup for suspected hereditary Parkinson's disease."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One Drop Blood on FTA Card
Sample Volume3-5 mL EDTA Blood
ContainerEDTA (Lavender Top) Tube or FTA Card
Collection MethodVenipuncture / FTA Card Blood Spot

Sample Stability

EDTA Whole Blood: Stable for up to 7 days at 2-8°C
Extracted DNA: Stable for up to 30 days at -20°C
FTA Card (dried blood spot): Stable at room temperature (15-25°C) for up to 6 months when stored in a sealed bag with desiccant
Sample Rejection Criteria:
  • Insufficient sample volume (less than 2 mL of EDTA blood)
  • Hemolyzed, clotted, or visibly contaminated blood sample
  • Incorrectly labeled or unlabeled samples
  • Samples received without a completed test requisition form or clinical history
  • Samples that have exceeded the specified stability period
  • FTA card samples that are wet, moldy, or improperly stored

Understanding Your Results

The LRRK2 Gene PARK8 Parkinson NGS Genetic Test results should be interpreted by a qualified geneticist or neurologist in the context of the patient's clinical presentation, family history, and other diagnostic findings. A positive result indicates the presence of a pathogenic or likely pathogenic variant in the LRRK2 gene, which is associated with an autosomal dominant pattern of inheritance and an increased lifetime risk of developing Parkinson's disease. However, it is important to note that LRRK2 mutations show incomplete penetrance, meaning not all carriers will necessarily develop the disease.
📊

Pathogenic Variant Detected

High

📊

Likely Pathogenic Variant Detected

Moderate to High

📊

Variant of Uncertain Significance (VUS)

Uncertain

📊

No Pathogenic Variant Detected

Negative

📊

Carrier of a Benign or Likely Benign Variant

None

⚠️ When to Consult a Doctor:

Consult a neurologist or genetic counselor if you have a family history of Parkinson's disease, are experiencing early symptoms such as tremors, rigidity, bradykinesia, or postural instability, or if you have received a positive or uncertain result from this genetic test. Individuals with a known LRRK2 mutation in the family should seek genetic counseling before and after testing. Early consultation can facilitate timely intervention, treatment planning, and access to ongoing clinical trials.

Limitations

  • ⚠This test analyzes only the LRRK2 gene and does not detect mutations in other Parkinson's disease-associated genes such as SNCA, PARK2, PINK1, PARK7, or GBA
  • ⚠A negative result does not rule out Parkinson's disease, as most cases are not caused by single-gene mutations
  • ⚠The test cannot predict the age of onset, severity, or progression of symptoms
  • ⚠Variants of uncertain significance (VUS) may be identified and may require further evaluation through family studies or functional assays
  • ⚠Deep intronic regulatory variants outside the targeted region may not be detected
  • ⚠This test is not designed to detect large copy number variations (CNVs) or structural rearrangements in the LRRK2 gene

Risks & Considerations

  • ●Minor bruising, swelling, or discomfort at the blood collection puncture site
  • ●Slight risk of infection at the venipuncture site (extremely rare with proper technique)
  • ●Potential psychological distress related to genetic results, particularly for presymptomatic individuals
  • ●Risk of anxiety or uncertainty if a variant of uncertain significance (VUS) is identified
  • ●Possible implications for life insurance or employment discrimination (consult local regulations and genetic non-discrimination protections)

Interfering Factors

  • ●Recent blood transfusion within the past 4 weeks may affect results due to donor DNA contamination
  • ●Prior bone marrow or stem cell transplant may yield misleading results
  • ●Sample contamination during collection or transport
  • ●Degraded DNA due to improper sample storage or prolonged transit time

Compare With Similar Tests

TestLRRK2 Gene PARK8 Parkinson NGS Genetic TestSNCA Gene Alpha-Synuclein Genetic TestPARK2 (Parkin) Gene Genetic TestPINK1 Gene Genetic TestComprehensive Parkinson's Disease Gene Panel
ComparisonLRRK2 Gene PARK8 Parkinson NGS Genetic Test

Frequently Asked Questions

What is the LRRK2 Gene PARK8 Parkinson NGS Genetic Test?
The LRRK2 Gene PARK8 Parkinson NGS Genetic Test is a next-generation sequencing (NGS) based genetic test that identifies mutations in the LRRK2 gene (also known as PARK8). The LRRK2 gene is one of the most common genetic contributors to Parkinson's disease, responsible for up to 5% of all cases. This test analyzes the entire coding region of the LRRK2 gene to detect known pathogenic mutations such as G2019S, R1441C, R1441G, R1441H, Y1699C, and I2020T, as well as other rare or novel variants.
Who should consider getting the LRRK2 genetic test?
This test is recommended for individuals with a family history of Parkinson's disease, patients diagnosed with early-onset Parkinson's disease (before age 50), individuals with an autosomal dominant pattern of Parkinson's in the family, at-risk family members seeking predictive testing, and patients being evaluated for eligibility in LRRK2-targeted clinical trials. A neurologist or genetic counselor can help determine if this test is appropriate for your situation.
What sample is required for the LRRK2 Gene PARK8 Genetic Test?
The test requires a small blood sample (3-5 mL) collected in an EDTA (lavender-top) tube through standard venipuncture. Alternatively, one drop of blood on an FTA card can be used, which is particularly convenient for remote locations. Extracted DNA from a previous test may also be accepted. No fasting is required before sample collection.
How long does it take to receive the LRRK2 genetic test results?
Results are typically available within 3 to 4 weeks from the date the sample is received at the laboratory. The comprehensive report includes variant findings, clinical interpretation, and recommendations. DNA Labs India also provides raw data, FASTQ files, and VCF files along with the clinical report for complete transparency and independent review.
What does a positive LRRK2 mutation result mean?
A positive result means a pathogenic or likely pathogenic mutation has been identified in the LRRK2 gene. This indicates a genetic predisposition to Parkinson's disease with autosomal dominant inheritance. However, LRRK2 mutations show incomplete penetrance, meaning not all carriers will develop Parkinson's disease. A positive result should be discussed with a genetic counselor and neurologist to understand implications for health management and family planning.
Can the LRRK2 genetic test diagnose Parkinson's disease?
The LRRK2 genetic test alone cannot definitively diagnose Parkinson's disease. It identifies genetic mutations that increase the risk of developing the condition. A diagnosis of Parkinson's disease is based on clinical evaluation, neurological examination, and response to dopaminergic therapy. Genetic testing serves as a supplementary tool that can confirm a genetic etiology and guide management strategies.
What is the cost of the LRRK2 Gene PARK8 Parkinson NGS Genetic Test in India?
The LRRK2 Gene PARK8 Parkinson NGS Genetic Test costs INR ?20,000 at DNA Labs India. This price includes free home sample collection across India, NGS-based genetic analysis, a genetic counseling session, the clinical test report with interpretation, and raw data files (FASTQ and VCF). The discounted price of ?20,000 is applicable for online bookings across all serviceable cities in India.
What are the common LRRK2 mutations tested in this analysis?
The most commonly tested LRRK2 mutations include G2019S (the most prevalent, located in the kinase domain), R1441C, R1441G, and R1441H (located in the ROC GTPase domain), Y1699C (located in the COR domain), and I2020T (located in the kinase domain). The NGS-based approach also enables detection of other rare or novel variants across all 51 exons of the LRRK2 gene.
Is genetic counseling required before and after the LRRK2 test?
Yes, genetic counseling is strongly recommended both before and after the LRRK2 genetic test. Pre-test counseling helps you understand the implications of testing, review your family pedigree, and provide informed consent. Post-test counseling is essential for interpreting results, discussing the significance of any variants found, understanding penetrance and inheritance patterns, and planning next steps including cascade testing of family members.
Can family members benefit from the LRRK2 genetic test results?
Yes, if a pathogenic LRRK2 mutation is identified in an affected individual, first-degree family members (parents, siblings, children) have a 50% chance of carrying the same mutation. Cascade testing of at-risk family members can identify carriers before symptoms develop, enabling early monitoring, lifestyle modifications, and potential enrollment in preventive clinical trials. Genetic counseling is recommended for all family members undergoing testing.
Does a negative LRRK2 test result rule out Parkinson's disease?
No, a negative LRRK2 test result does not rule out Parkinson's disease. The majority of Parkinson's disease cases (approximately 85-90%) are classified as idiopathic and are not caused by single-gene mutations. Additionally, mutations in other genes such as SNCA, PARK2, PINK1, PARK7, and GBA can also cause hereditary Parkinson's disease. A comprehensive clinical evaluation by a neurologist remains essential for diagnosis.
Does DNA Labs India share raw genetic data files with patients?
Yes, DNA Labs India is the only laboratory in India that provides raw data, FASTQ files, and VCF files along with the conclusive clinical test report for the LRRK2 Gene PARK8 Parkinson NGS Genetic Test. This ensures full transparency and allows patients and their healthcare providers to independently verify results, seek second opinions, or use the data for research purposes.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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