MAPK10 Gene Epileptic encephalopathy, Lennox-Gastaut type NGS Genetic Test
Short Name: MAPK10 Gene LGS NGS Genetic Test
Also known as: MAPK10 Gene Epileptic Encephalopathy NGS Test, Lennox-Gastaut Syndrome MAPK10 Gene Test, MAPK10 Next Generation Sequencing Test
MAPK10 Gene Epileptic encephalopathy, Lennox-Gastaut type NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS), Targeted Gene Sequencing on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are delivered within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to identify disease-causing pathogenic or likely pathogenic variants in the MAPK10 gene that may be responsible for Lennox-Gastaut syndrome. A confirmed molecular diagnosis assists clinicians in clinical management, neurodevelopmental surveillance, and family counselling regarding recurrence risk.
- Test Code
- 4088
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are delivered within 3 to 4 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Targeted Gene Sequencing
Sample Collection
No fasting is required. Genetic counselling is recommended before the test so that the patient and family understand the purpose, benefits, risks, and possible outcomes. The referring neurologist or geneticist will review the clinical history, seizure types, EEG findings, and family pedigree.
Method: Blood draw / FTA card spot / purified DNA submission
Laboratory Analysis
A small blood sample is collected by venipuncture, or a drop of blood is placed on an FTA card. In some cases, extracted DNA may be sent directly to the laboratory. The procedure is quick and involves minimal discomfort.
Report Delivery
No special aftercare is needed. The sample is transported to the laboratory for NGS analysis. The patient can resume normal activities and diet immediately after collection.
Timeline: Reports are delivered within 3 to 4 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to identify disease-causing pathogenic or likely pathogenic variants in the MAPK10 gene that may be responsible for Lennox-Gastaut syndrome. A confirmed molecular diagnosis assists clinicians in clinical management, neurodevelopmental surveillance, and family counselling regarding recurrence risk.
How to Prepare
- For blood: collect in an EDTA tube and label with patient details
- For FTA card: apply one drop of blood, air-dry completely, and pack safely
- For extracted DNA: provide sample quality/quantity information alongside the DNA
- All samples must be labelled with patient name, date of birth, and collection date
- Maintain sample at ambient temperature unless otherwise instructed by the laboratory
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"In families with a child suspected to have Lennox-Gastaut syndrome, a precise genetic diagnosis helps guide treatment choices and recurrence-risk counselling. The MAPK10 NGS test is a focused option when MAPK10-related disorder is clinically suspected."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolysed blood sample
- Insufficient sample quantity or DNA concentration
- Improperly labelled or unlabeled sample
- Leaked or contaminated sample
- Sample received beyond the recommended transport time
Understanding Your Results
A pathogenic or likely pathogenic variant in MAPK10 was identified. This is consistent with a molecular diagnosis of MAPK10-related Lennox-Gastaut syndrome.
Result type: Positive
No pathogenic or likely pathogenic variant in MAPK10 was detected. This does not exclude MAPK10-related disease due to variants in regions not covered, or an alternate genetic cause.
Result type: Negative
A variant was found but its clinical significance is unknown. Additional familial testing and clinical correlation may be required.
Result type: Variant of Uncertain Significance (VUS)
No clinically significant alteration was identified and the variant is unlikely to be disease-causing.
Result type: Benign / Likely Benign
If your child or a family member has recurrent seizures, developmental delay, abnormal EEG, or features suggestive of Lennox-Gastaut syndrome, consult a pediatric neurologist or clinical geneticist. Genetic counselling before and after testing is strongly advised.
Limitations
- ⚠This targeted NGS test analyzes only the MAPK10 gene and does not rule out other genetic causes of Lennox-Gastaut syndrome
- ⚠Standard NGS may not detect large structural variants, deep intronic mutations, or repeat expansions
- ⚠Variants of uncertain significance may require additional testing or familial segregation studies
- ⚠Genetic test results must always be interpreted in the context of clinical and EEG findings
Risks & Considerations
- ●No significant medical risks are associated with this genetic test
- ●Minor pain or bruising may occur at the blood-draw site
- ●Rarely, dizziness or fainting may occur during blood collection
Interfering Factors
- ●Poor quality or insufficient quantity of DNA
- ●Sample contamination or mix-up
- ●Variants outside the coding and splice-site regions analysed
- ●Large gene deletions or duplications not reliably detected by standard NGS
- ●Mosaicism below the detection threshold of the assay
Compare With Similar Tests
| Test | MAPK10 Gene Epileptic encephalopathy, Lennox-Gastaut type NGS Genetic Test | |||
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| Comparison | MAPK10 Gene Epileptic encephalopathy, Lennox-Gastaut type NGS Genetic Test |
Frequently Asked Questions
What is Lennox-Gastaut syndrome?
What is the role of the MAPK10 gene in epileptic encephalopathy?
What does this NGS genetic test analyze?
What is the cost of the MAPK10 gene Lennox-Gastaut NGS genetic test?
What sample is required for the test?
Is fasting required before the test?
Who should take this test?
How long does it take to get reports?
Do I need genetic counselling before this test?
Can this test detect all causes of Lennox-Gastaut syndrome?
Will NGS detect large deletions or duplications in the MAPK10 gene?
What does a negative result mean?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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