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DNA Labs India

MAPT Gene Dementia, frontotemporal NGS Genetic Test

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MAPT Gene Dementia, frontotemporal NGS Genetic Test

Short Name: MAPT Gene NGS Test

Also known as: MAPT Gene Mutation Test, Frontotemporal Dementia Genetic Test, Tau Protein Gene Test, MAPT NGS Panel

MAPT Gene Dementia, frontotemporal NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are available in 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

This test is used to detect pathogenic variants in the MAPT gene that are associated with frontotemporal dementia and other tauopathies. It helps confirm a clinical diagnosis, guide management decisions, and identify at-risk family members for predictive testing and genetic counselling.

Test Code
3998
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are available in 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Medical history and prior genetic counselling are recommended. Patients should bring a valid ID and any relevant clinical records.

Method: Venipuncture or fingerstick

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm, or a fingerstick blood spot will be collected on an FTA card. The procedure takes only a few minutes.

Step 3

Report Delivery

No specific aftercare is required. Patients may resume normal activities immediately. Raw data and the clinical report will be provided within 3-4 weeks.

Timeline: Reports are available in 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:Prior to the test, a genetic counselling session is advised to review the family pedigree, discuss the implications of results, and obtain informed consent.
2
During the Test:The test involves a simple blood draw or fingerstick collection. No pain or discomfort beyond the routine sample collection is expected.
3
After the Test:After the test, the sample is sent to the laboratory for NGS analysis. Results will be shared through the patient portal and by email. Genetic counselling is advised once results are available.

About This Test

Who Should Get This Test

This test is used to detect pathogenic variants in the MAPT gene that are associated with frontotemporal dementia and other tauopathies. It helps confirm a clinical diagnosis, guide management decisions, and identify at-risk family members for predictive testing and genetic counselling.

How to Prepare

  • For blood collection, use an EDTA vacutainer.
  • For FTA card collection, apply 1-2 drops of blood onto the marked circle and allow it to dry completely.
  • Label the sample with patient name and date of collection.
  • Transport the sample at ambient temperature if delivering within 24 hours; refrigerate if delayed.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"A neurologist may recommend this test for patients presenting with early-onset behavioral changes or language deficits suggestive of frontotemporal dementia. It aids in distinguishing FTD from psychiatric mimics and supports family counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood or 1-2 drops on FTA card
ContainerEDTA vacutainer or FTA card
Collection MethodVenipuncture or fingerstick

Sample Stability

Blood: stable at room temperature for 24-48 hours.
Blood: stable at 2-8°C for up to 7 days.
Extracted DNA: stable at -20°C for several months.
FTA card: stable at room temperature for up to a year.
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Unlabeled or mislabeled sample
  • Sample container damaged or leaking

Understanding Your Results

The interpretation of the MAPT gene NGS test is based on the absence or presence of pathogenic variants. Results should be correlated with clinical features and family history. A positive result indicates a genetic cause of frontotemporal dementia.
📊

Pathogenic variant detected

This confirms a genetic diagnosis of FTD caused by a MAPT mutation. Predictive testing in at-risk family members is possible. Genetic counselling is recommended.

📊

Variant of uncertain significance (VUS) detected

A variant with unknown clinical significance was found. Further family studies or functional studies may be needed. Clinical correlation is essential.

📊

No pathogenic variant detected

The result is negative. A genetic cause in MAPT is unlikely, but other genes may be involved. Consider broader FTD panel testing and clinical review.

⚠️ When to Consult a Doctor:

Consult a neurologist or geneticist if you or a family member experience early-onset behavioral changes, progressive language difficulty, personality changes, or have a known family history of frontotemporal dementia. Genetic testing should be performed with pre- and post-test counselling.

Limitations

  • ⚠This test detects mutations only in the MAPT gene; other genes causing FTD are not covered.
  • ⚠Not all pathogenic variants may be identified due to limitations of NGS technology (e.g., deep intronic or structural variants).
  • ⚠A negative result does not exclude a genetic cause of frontotemporal dementia.
  • ⚠Results should be interpreted in the context of clinical history and family pedigree.

Risks & Considerations

  • ●Minimal risk of bruising or infection at the needle stick site
  • ●Psychological impact of genetic test results, including possible anxiety or distress
  • ●Potential implications for family members and insurance

Interfering Factors

  • ●Low DNA quality or quantity may reduce assay sensitivity.
  • ●Rarely, genetic variants in regions not covered by NGS may be missed.

Compare With Similar Tests

TestMAPT Gene Dementia, frontotemporal NGS Genetic TestFrontotemporal Dementia Full NGS Panel (MAPT, GRN, C9orf72, TARDBP, FUS)
ComparisonMAPT Gene Dementia, frontotemporal NGS Genetic TestComprehensive panel covering multiple FTD-related genes. Recommended when MAPT-negative or when genetic cause is not suspected in a single gene.

Frequently Asked Questions

What is the MAPT gene?
The MAPT gene provides instructions for making the tau protein, which helps stabilize microtubules in nerve cells. Mutations in this gene can lead to frontotemporal dementia.
How does MAPT cause frontotemporal dementia?
Pathogenic variants in MAPT lead to abnormal tau protein accumulation, causing neuronal dysfunction and death in the frontal and temporal lobes, resulting in FTD symptoms.
Who should take this test?
Individuals with clinical features suggestive of FTD, family history of FTD or related dementia, or those seeking predictive testing after a known familial mutation.
What sample is needed?
Blood, extracted DNA, or a single drop of blood on an FTA card is accepted for the test.
What is the cost of the test?
The test costs INR 20000. This includes free home collection and the clinical report along with raw data files.
Do I need to fast before the test?
No, fasting is not required for this genetic test.
How long will the reports take?
Reports are typically available in 3 to 4 weeks after the sample is received by the laboratory.
Will I receive raw data files?
Yes, DNA Labs India provides FASTQ and VCF files along with the clinical report.
What do the results indicate?
A positive result confirms a pathogenic MAPT variant associated with FTD. A negative result suggests no MAPT mutation was detected, but other genetic causes may be possible.
Is this test suitable for prenatal testing?
This test is not intended for prenatal diagnosis. Preimplantation or prenatal testing for FTD requires specialist counselling and a separate validated method.
Can the test be done from any city in India?
Yes, we offer free home sample collection across multiple cities in India. Please check our service locations for availability.
Do I need genetic counselling?
Yes, genetic counselling before and after the test is strongly recommended to understand the implications for you and your family.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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