MATR3 Gene Amyotrophic Lateral Sclerosis Type 21 NGS Genetic Test
Short Name: MATR3 ALS21 NGS Test
Also known as: MATR3 NGS Test, MATR3 ALS21 Genetic Test, Matrin-3 Gene Sequencing, Familial ALS Type 21 Genetic Test
MATR3 Gene Amyotrophic Lateral Sclerosis Type 21 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood, Extracted DNA, or One Drop Blood on FTA Card samples. Results in Clinically conclusive report and raw data files are issued within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect sequence variants in the MATR3 gene that are associated with amyotrophic lateral sclerosis type 21. Early molecular confirmation can support patient management, clarify inheritance, and provide information for family members who may be at risk.
- Test Code
- 3887
- ICD Code
- G12.21
- Price
- ₹20,000
- Sample Type
- Blood, Extracted DNA, or One Drop Blood on FTA Card
- Result Time
- Clinically conclusive report and raw data files are issued within 3 to 4 weeks from sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. Please carry a valid photo ID, doctor’s referral, and previous investigation reports. A genetic counselling session may be arranged by the laboratory before collection if not already completed.
Method: Peripheral blood draw / DNA extraction / FTA card spot
Laboratory Analysis
A trained phlebotomist will collect blood in an EDTA vacutainer. For FTA card collection, one drop of blood is applied to the marked area and allowed to air dry before placing it in the provided envelope.
Report Delivery
Apply gentle pressure to the venipuncture site for a few minutes. There are no dietary or activity restrictions after sample collection.
Timeline: Clinically conclusive report and raw data files are issued within 3 to 4 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect sequence variants in the MATR3 gene that are associated with amyotrophic lateral sclerosis type 21. Early molecular confirmation can support patient management, clarify inheritance, and provide information for family members who may be at risk.
How to Prepare
- Use an EDTA vacutainer for whole blood collection; do not use heparin
- If using FTA card, collect in the marked circle and air-dry completely before sealing
- Extracted DNA should be supplied with adequate concentration and purity as specified by the laboratory
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for ALS should always be combined with pre-test and post-test genetic counselling. A MATR3 variant alone does not predict age of onset or disease severity; therefore, results must be interpreted within the context of neurological examination and family pedigree."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or severely hemolyzed sample
- Sample without a matching requisition form
- Incorrectly labelled or unlabelled sample
- Insufficient DNA concentration or degraded DNA
Understanding Your Results
No pathogenic variant detected
Negative test for sequence variants in the coding and splice-site regions of the MATR3 gene tested. It does not rule out other genetic or non-genetic causes of ALS.
Pathogenic / Likely pathogenic variant detected
Variant is considered disease-causing or likely disease-causing. Clinical correlation, family counselling and predictive testing of at-risk relatives are recommended.
Variant of uncertain significance (VUS)
DNA change is identified but its clinical significance is not yet established. Family co-segregation studies and additional functional evidence may be required.
Inadequate coverage
Some target regions were not covered sufficiently for a definitive clinical conclusion. Repeat testing or supplementary testing may be needed for those regions.
If you or your family member has progressive muscle weakness, difficulty swallowing or speaking, or a known family history of ALS, you should consult a neurologist and a clinical geneticist. If a pathogenic MATR3 variant is identified, family counseling is strongly advised.
Limitations
- ⚠This test is not a complete ALS multigene panel; a negative result does not exclude other ALS-related genes
- ⚠This NGS test is not designed to detect large deletions/duplications, trinucleotide repeat expansions, mitochondrial mutations or structural rearrangements
- ⚠Variant classification may change over time as new clinical and functional evidence becomes available
Risks & Considerations
- ●Minor pain, bruising, or bleeding at the venipuncture site
- ●Potential psychological impact from receiving a genetic diagnosis
- ●Potential implications for family members and future life decisions
Interfering Factors
- ●Poor DNA quality or low DNA quantity may reduce NGS coverage
- ●Sample contamination can produce false results
- ●Regions with high sequence homology or pseudogenes may complicate interpretation
- ●Large structural rearrangements, repeat expansions and deep intronic variants may not be detected by this NGS test
Compare With Similar Tests
| Test | MATR3 Gene Amyotrophic Lateral Sclerosis Type 21 NGS Genetic Test | SOD1 Gene ALS NGS Genetic Test | C9orf72 Repeat Expansion ALS Genetic Test | FUS Gene ALS NGS Genetic Test | TARDBP Gene ALS NGS Genetic Test |
|---|---|---|---|---|---|
| Comparison | MATR3 Gene Amyotrophic Lateral Sclerosis Type 21 NGS Genetic Test |
Frequently Asked Questions
What is the MATR3 gene test for ALS type 21?
What does ALS type 21 mean?
Do I need to fast before this test?
What type of sample is accepted?
How much does this test cost?
How long will my report take?
Will I receive raw data files?
If the test is negative, does it rule out ALS?
What is a variant of uncertain significance?
Is genetic counselling necessary?
Is this test covered by insurance?
Can this test be used for prenatal diagnosis?
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