MDM2 Test
Also known as: MDM2 gene amplification test, MDM2 FISH test, MDM2 oncogene analysis
MDM2 Test test available at DNA Labs India for ₹9,000. Uses FISH (Fluorescence In Situ Hybridization) on Tumor tissue (paraffin-embedded block) samples. Results in Results are typically available within 7-8 days after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the MDM2 test is to detect amplification or overexpression of the MDM2 gene in tumor tissue, which is crucial for diagnosing certain cancers, particularly soft tissue sarcomas and liposarcomas. It helps in differentiating benign from malignant tumors, guiding treatment decisions, and predicting patient prognosis. The test is also used to identify patients who may benefit from MDM2-targeted therapies.
- Test Code
- 6127
- CPT Code
- 88377
- ICD Code
- C80.1
- Price
- ₹9,000
- Sample Type
- Tumor tissue (paraffin-embedded block)
- Result Time
- Results are typically available within 7-8 days after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- FISH (Fluorescence In Situ Hybridization)
Sample Collection
A doctor's prescription is required. Inform your doctor about any medications or ongoing treatments. No fasting is required.
Method: Biopsy or surgical resection specimen
Laboratory Analysis
The sample is collected via biopsy or surgical excision. The tissue is placed in a fixative solution and sent to the laboratory.
Report Delivery
No specific precautions are needed. You can resume normal activities immediately.
Timeline: Results are typically available within 7-8 days after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the MDM2 test is to detect amplification or overexpression of the MDM2 gene in tumor tissue, which is crucial for diagnosing certain cancers, particularly soft tissue sarcomas and liposarcomas. It helps in differentiating benign from malignant tumors, guiding treatment decisions, and predicting patient prognosis. The test is also used to identify patients who may benefit from MDM2-targeted therapies.
How to Prepare
- Tissue sample must be fixed in 10% neutral buffered formalin
- Paraffin-embedded tissue block or unstained slides should be provided
- Sample must be accompanied by a requisition form with patient details
- Ensure proper labeling and packaging for transport
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"MDM2 amplification is a key biomarker in soft tissue tumors and liposarcomas. FISH testing provides definitive evidence for targeted therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Inadequate tissue sample (less than 5 mm)
- Poor fixation or autolyzed tissue
- Incorrect container or fixative
- Unlabeled or mislabeled sample
Understanding Your Results
Negative
No MDM2 amplification detected. Likely benign or non-MDM2 related tumor.
Positive
MDM2 amplification detected. Supports diagnosis of liposarcoma or other MDM2-driven tumors. May indicate potential benefit from MDM2 inhibitors.
Consult your oncologist if you experience unexplained weight loss, persistent fatigue, unusual bleeding, or a growing lump. Early diagnosis can improve treatment outcomes.
Limitations
- ⚠FISH detects amplification but not expression levels
- ⚠Results depend on tissue quality and sample adequacy
- ⚠Not a standalone diagnostic test; clinical correlation required
- ⚠May not detect all MDM2 alterations (e.g., point mutations)
Risks & Considerations
- ●Minimal risk of bleeding or infection at biopsy site
- ●Rare allergic reaction to local anesthetic
- ●No radiation exposure from FISH test
Interfering Factors
- ●Inadequate tissue sample or poor fixation
- ●Decalcification of bone tissue may affect FISH results
- ●Necrotic or hemorrhagic tissue may reduce signal quality
- ●Prior chemotherapy or radiation may alter gene expression
Compare With Similar Tests
| Test | MDM2 | MDM2 FISH | MDM2 IHC | NGS Panel |
|---|---|---|---|---|
| Comparison | MDM2 | Detects gene amplification with high sensitivity and specificity. | Detects protein overexpression, but less specific than FISH. | Comprehensive genomic profiling, but more expensive and time-consuming. |
Frequently Asked Questions
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