Metanephrines Fractionated Random Urine Test
Short Name: Metanephrines Urine Test
Also known as: Fractionated Metanephrines Urine Test, Metanephrines Random Urine Analysis
Metanephrines Fractionated Random Urine Test test available at DNA Labs India for ₹8,500. Uses HPLC-EC on Random Urine samples. Results in Sample collection on Wednesday/Saturday by 9 am; reports available on Friday/Tuesday.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
To measure metanephrine and normetanephrine levels in urine for diagnosing pheochromocytoma and related adrenal disorders.
- Test Code
- 1228
- Price
- ₹8,500
- Sample Type
- Random Urine
- Result Time
- Sample collection on Wednesday/Saturday by 9 am; reports available on Friday/Tuesday.
- Fasting Required
- No
- Method
- HPLC-EC
Sample Collection
Patient should strictly avoid Alpha-Methyldopa, Buspirone, Codeine, Isoproterenol metabolite, Mandelamine, L-dopa, Paracetamol, Metoclopramide, pepper, alcoholic beverages, tea/coffee, tobacco and strenuous exercise at least 72 hours before and during specimen collection.
Method: Urine Collection
Laboratory Analysis
Collect a random urine sample in a clean container. Add 50% HCl drop by drop to bring the pH between 1-2, avoiding concentrated HCl. Mix well and refrigerate or freeze immediately.
Report Delivery
Store the sample as instructed and transport to the lab promptly. No specific post-collection care required.
Timeline: Sample collection on Wednesday/Saturday by 9 am; reports available on Friday/Tuesday.
Patient Instructions
About This Test
Who Should Get This Test
To measure metanephrine and normetanephrine levels in urine for diagnosing pheochromocytoma and related adrenal disorders.
How to Prepare
- Collect a random urine sample (minimum 10 mL).
- Add 50% HCl drop by drop to adjust pH to 1-2.
- Do not use concentrated HCl.
- Ship refrigerated or frozen.
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"This test is essential for diagnosing adrenal tumors like pheochromocytoma, aiding in timely treatment and management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not properly preserved with HCl.
- Inadequate volume (<10 mL).
- Sample contaminated or mishandled.
Understanding Your Results
Normal levels
No significant adrenal tumor indicated; consult doctor for further evaluation if symptoms persist.
Elevated metanephrine
Possible pheochromocytoma; additional tests like imaging may be required for confirmation.
Elevated normetanephrine
May indicate adrenal dysfunction; correlate with clinical symptoms and other diagnostic tests.
If test results are abnormal or if symptoms like high blood pressure, headaches, or palpitations persist, consult an oncologist or endocrinologist for further evaluation.
Limitations
- ⚠Results may be affected by certain medications and substances.
- ⚠Random urine samples may have variability; 24-hour urine collection might be preferred in some cases.
- ⚠False positives or negatives can occur; clinical correlation is necessary.
Interfering Factors
- ●Alpha-Methyldopa
- ●Buspirone
- ●Codeine
- ●Isoproterenol metabolite
- ●Mandelamine
- ●L-dopa
- ●Paracetamol
- ●Metoclopramide
- ●Pepper
- ●Alcoholic beverages
- ●Tea/coffee
- ●Tobacco
- ●Strenuous exercise
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