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MSH2 Gene Muir-Torre syndrome NGS Genetic Test

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MSH2 Gene Muir-Torre syndrome NGS Genetic Test

Short Name: MSH2 Muir-Torre NGS Test

Also known as: MSH2 Gene Test, Muir-Torre Syndrome Genetic Test, Hereditary Cancer Syndrome Test

MSH2 Gene Muir-Torre syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the MSH2 Gene Muir-Torre Syndrome NGS Genetic Test is to identify mutations in the MSH2 gene that cause Muir-Torre syndrome. This helps in assessing the risk of developing associated cancers, enabling early intervention, genetic counseling, and informed decision-making for patients and their families.

Test Code
2912
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Schedule an appointment, provide medical history, and sign consent forms.
2
During the Test:Blood sample collection and processing in the laboratory for NGS sequencing.
3
After the Test:Wait for results, which will be delivered in 3-4 weeks, and follow up with genetic counseling.

About This Test

Who Should Get This Test

The purpose of the MSH2 Gene Muir-Torre Syndrome NGS Genetic Test is to identify mutations in the MSH2 gene that cause Muir-Torre syndrome. This helps in assessing the risk of developing associated cancers, enabling early intervention, genetic counseling, and informed decision-making for patients and their families.

How to Prepare

  • Bring identification and doctor's prescription
  • Inform about any medications or health conditions
  • Ensure sample is properly labeled

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is essential for individuals with a family history of Muir-Torre syndrome to identify mutations in the MSH2 gene, enabling proactive cancer screening and management."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 ml blood
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Blood sample stable at room temperature for 48 hours
Extracted DNA stable for longer periods under proper storage
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or clotted sample
  • Improperly labeled or contaminated sample

Understanding Your Results

The results of the MSH2 Gene Muir-Torre Syndrome NGS Genetic Test indicate the presence or absence of mutations in the MSH2 gene. A positive result suggests a diagnosis of Muir-Torre syndrome and increased cancer risk.
Positive: Mutation detected – consult genetic counselor for risk management and cancer screening
Negative: No mutation detected – reduced risk but not zero; continue regular check-ups
Variant of Uncertain Significance: Further testing and monitoring recommended with genetic counseling
⚠️ When to Consult a Doctor:

If the test result is positive or if there is a family history of Muir-Torre syndrome, consult a genetic counselor or oncologist for personalized advice and management.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results may include variants of uncertain significance
  • ⚠Does not replace clinical diagnosis

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestMSH2 Gene Muir-Torre syndrome NGS Genetic TestLynch Syndrome PanelSingle Gene Sequencing
ComparisonMSH2 Gene Muir-Torre syndrome NGS Genetic Test

Frequently Asked Questions

What is Muir-Torre syndrome?
Muir-Torre syndrome is a rare hereditary condition caused by mutations in the MSH2 gene, leading to an increased risk of developing cancers such as colorectal, endometrial, ovarian, and skin cancers.
What is the role of the MSH2 gene?
The MSH2 gene provides instructions for producing a protein involved in DNA mismatch repair, which helps fix errors during DNA replication.
Who should consider the MSH2 Gene Muir-Torre Syndrome NGS Genetic Test?
Individuals with a family history of Muir-Torre syndrome, symptoms like sebaceous adenomas, or a personal/family history of associated cancers.
How is the test sample collected?
A small blood sample is collected via venipuncture, or extracted DNA or a blood drop on an FTA card can be used.
What is the cost of the test in India?
The test costs INR 20000 at DNA Labs India, with free home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to receive the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive test result indicate?
A positive result means a mutation in the MSH2 gene has been detected, confirming Muir-Torre syndrome and an increased cancer risk.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising or infection, and potential psychological impact from the results.
Can this test be used for prenatal diagnosis?
This test is primarily for diagnostic purposes in individuals with symptoms or family history; prenatal testing may require additional genetic counseling.
How accurate is the NGS Genetic Test?
NGS is highly accurate for detecting mutations in the MSH2 gene, but no test is 100% foolproof; variants of uncertain significance may be found.
What should I do after receiving the test results?
Consult a genetic counselor or healthcare provider to understand the implications, discuss risk management, and plan for cancer screening or prevention.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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