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DNA Labs India

MSH6 Gene Endometrial cancer, familial, MSH6 related NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

MSH6 Gene Endometrial cancer, familial, MSH6 related NGS Genetic Test

Short Name: MSH6 Endometrial Cancer NGS Test

Also known as: MSH6 mutation test, Hereditary endometrial cancer genetic test, Lynch syndrome MSH6 test

MSH6 Gene Endometrial cancer, familial, MSH6 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestFemaleAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the MSH6 gene that increase the risk of hereditary endometrial cancer, aiding in early diagnosis, risk assessment, and personalized healthcare planning.

Test Code
2867
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree as advised during genetic counseling.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or FTA card. Minimal discomfort expected.

Step 3

Report Delivery

Apply pressure to the puncture site. Resume normal activities. Store samples as instructed.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling recommended to discuss implications and draw a family pedigree chart.
2
During the Test:Sample collection procedure as per standard protocols.
3
After the Test:Results delivered in 3-4 weeks. Follow-up counseling advised for result interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the MSH6 gene that increase the risk of hereditary endometrial cancer, aiding in early diagnosis, risk assessment, and personalized healthcare planning.

How to Prepare

  • Ensure proper identification and labeling of samples
  • Use sterile collection equipment
  • Follow transport guidelines for sample stability

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for women with a family history of endometrial cancer to assess genetic risk and guide preventive care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic MSH6 gene mutations. A positive result suggests increased genetic risk for endometrial cancer, while a negative result does not eliminate all risk.
Positive: Pathogenic variant detected – increased cancer risk; recommend enhanced surveillance and genetic counseling.
Negative: No pathogenic variant detected – risk may be lower, but other factors may apply.
Variant of uncertain significance (VUS): Further testing or family studies may be needed.
⚠️ When to Consult a Doctor:

Consult a doctor if you have a family history of endometrial cancer, experience symptoms like abnormal bleeding, or receive a positive genetic test result for personalized management.

Limitations

  • ⚠Test only analyzes the MSH6 gene; other genetic causes may not be detected
  • ⚠Does not predict cancer onset with certainty; risk assessment only
  • ⚠Variant interpretation may require additional family studies

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic risk information

Interfering Factors

  • ●Poor sample quality or contamination
  • ●Insufficient DNA quantity
  • ●Hemolyzed blood samples

Frequently Asked Questions

What is the MSH6 Gene Endometrial Cancer NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the MSH6 gene, which are associated with an increased risk of hereditary endometrial cancer.
Who should consider this test?
Individuals with a family history of endometrial cancer, colorectal cancer, or other Lynch syndrome-related cancers, or those with symptoms like abnormal vaginal bleeding.
What is the cost of the test in India?
The test costs INR 20,000 at DNA Labs India, with home sample collection available across India.
How is the test performed?
A blood sample or extracted DNA is analyzed using NGS technology to identify mutations in the MSH6 gene.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the MSH6 gene, which increases the risk of endometrial cancer. Genetic counseling is recommended for management.
What does a negative result mean?
A negative result means no pathogenic mutations were detected in the MSH6 gene, but it does not eliminate all cancer risk due to other genetic or environmental factors.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
What files are provided with the report?
Along with the clinical report, DNA Labs India provides raw data files including FASTQ and VCF files for transparency.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising. Psychological impact of results is possible, so genetic counseling is advised.
Is this test covered by insurance?
Coverage depends on the insurance policy. It is not typically covered under government schemes like PMJAY or CGHS, but check with your provider.
What should I do after receiving the results?
Consult a healthcare provider or genetic counselor to discuss the results, understand implications, and plan for surveillance or preventive measures.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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