MT-ND6 Gene Mitochondrial complex I deficiency NGS Genetic Test
Short Name: MT-ND6 NGS Test
Also known as: MT-ND6 Gene Sequencing Test, Mitochondrial Complex I Deficiency MT-ND6 Panel, ND6 Mitochondrial Gene NGS Test
MT-ND6 Gene Mitochondrial complex I deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect pathogenic variants in the MT-ND6 gene, confirm a clinical diagnosis of mitochondrial complex I deficiency, and guide medical management and family counseling.
- Test Code
- 4307
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. A genetic counseling session is recommended to draw a family pedigree and assess inheritance risk.
Method: Blood draw / FTA card blood spot / DNA sample
Laboratory Analysis
A small blood sample is collected from a vein. If FTA card is used, a few drops of blood are placed on the card and allowed to dry.
Report Delivery
The specimen is transported to the lab for processing. The report will be shared within 3 to 4 weeks.
Timeline: 3 to 4 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect pathogenic variants in the MT-ND6 gene, confirm a clinical diagnosis of mitochondrial complex I deficiency, and guide medical management and family counseling.
How to Prepare
- No fasting is required.
- The sample can be taken at any time of the day.
- If using FTA card, allow the blood spot to air dry before placing it in the provided envelope.
- For extracted DNA, provide concentration and purity information if available.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"The clinical phenotype of mitochondrial complex I deficiency can be highly variable. A molecular genetic test result should always be interpreted together with biochemical and radiological findings for optimal patient care."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed or frozen whole blood
- Improperly labelled samples
- Incomplete clinical history
- Insufficient sample quantity
Understanding Your Results
No pathogenic variant detected
A molecular cause in MT-ND6 was not found. Additional mitochondrial or nuclear gene testing may be considered.
Pathogenic variant detected
The variant is known to cause disease and is consistent with mitochondrial complex I deficiency.
Likely pathogenic variant detected
The variant is highly suspected to be disease-causing; clinical correlation is required.
Variant of uncertain significance (VUS) detected
The variant cannot yet be classified as benign or pathogenic; further family studies may be helpful.
If you or a family member have symptoms suggestive of mitochondrial complex I deficiency, or if the test reveals a likely pathogenic/pathogenic variant, consult your referring physician or a clinical geneticist.
Limitations
- ⚠This test covers only the MT-ND6 gene and does not assess other mitochondrial or nuclear complex I genes.
- ⚠Standard NGS may not reliably detect large deletions, duplications, or structural rearrangements.
- ⚠Variant interpretation may be inconclusive for variants of uncertain significance.
- ⚠The absence of a pathogenic variant does not exclude mitochondrial disease.
Risks & Considerations
- ●No significant physical risk.
- ●Minimal discomfort from blood draw.
- ●Rare chance of bruising or light-headedness.
Interfering Factors
- ●Recent blood transfusion or bone marrow transplant may cause mixed DNA results.
- ●Maternal cell contamination in the sample affects mitochondrial DNA analysis.
- ●Poor DNA quality or quantity can reduce assay sensitivity.
- ●Very low levels of mutant mitochondrial DNA (heteroplasmy) may fall below the detection threshold.
Compare With Similar Tests
| Test | MT-ND6 Gene Mitochondrial complex I deficiency NGS Genetic Test | MT-ND6 Targeted NGS Test | Whole Mitochondrial Genome Sequencing |
|---|---|---|---|
| Comparison | MT-ND6 Gene Mitochondrial complex I deficiency NGS Genetic Test |
Frequently Asked Questions
What is the price of the MT-ND6 gene mitochondrial complex I deficiency NGS genetic test at DNA Labs India?
What sample types are accepted for this test?
Does this test require fasting?
How long will it take to get the report?
What symptoms may prompt this test?
What technology is used for this test?
Will I receive raw data with the report?
Is home sample collection available?
Do I need genetic counseling before testing?
What does a negative MT-ND6 result mean?
Can this test detect all mitochondrial complex I disorders?
Who should order this test?
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