MT-TT Gene Parkinson disease, susceptibility to, MT-TT related NGS Genetic Test
Short Name: MT-TT Parkinson's NGS Test
Also known as: MT-TT Gene Mutation Analysis, Mitochondrial tRNA Threonine Gene Test, Parkinson's Disease Susceptibility Genetic Test, MT-TT Mitochondrial NGS Test
MT-TT Gene Parkinson disease, susceptibility to, MT-TT related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS), Sanger confirmation (if applicable) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
This NGS-based genetic test detects mutations in the MT-TT gene, which has been associated with increased susceptibility to Parkinson's disease. The test helps clinicians assess hereditary risk, support early diagnosis, and guide genetic counseling and family planning decisions.
- Test Code
- 4442
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks after sample collection.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS), Sanger confirmation (if applicable)
Sample Collection
No specific preparation is required. Genetic counseling is recommended before undergoing this test to understand the implications of potential results.
Method: Blood draw or DNA extraction or FTA spot
Laboratory Analysis
A blood sample is drawn by a trained phlebotomist using standard sterile technique. For FTA card, one drop of blood is applied onto the designated card. For extracted DNA, the sample is transferred to a sterile tube.
Report Delivery
No restrictions are required. You can resume normal diet and activities. The laboratory will process the sample for NGS analysis.
Timeline: 3 to 4 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
This NGS-based genetic test detects mutations in the MT-TT gene, which has been associated with increased susceptibility to Parkinson's disease. The test helps clinicians assess hereditary risk, support early diagnosis, and guide genetic counseling and family planning decisions.
How to Prepare
- Maintain sample at ambient temperature during transport
- Use EDTA tube for blood collection
- Do not freeze the blood sample before processing
- Label the sample tube/card clearly with patient details
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for Parkinson's disease susceptibility provides important information for family planning and early intervention. A positive result does not confirm disease onset, but supports close monitoring and lifestyle modifications. Genetic counseling is strongly recommended before and after testing."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolysed or clotted blood sample
- Improperly labeled or unlabeled sample
- Leaking or damaged sample container
- Insufficient quantity of DNA or blood for analysis
Understanding Your Results
Negative
No pathogenic variants were detected in the MT-TT gene. This does not rule out Parkinson's disease, as other genetic and environmental factors may be involved.
Positive
A pathogenic/likely pathogenic variant in the MT-TT gene was detected. This indicates an increased susceptibility to Parkinson's disease, but it does not confirm that the disease will definitely develop.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is not yet established. Further testing of family members or additional functional studies may be needed.
If you have a family history of Parkinson's disease, experience early motor symptoms such as tremor or rigidity, or have received a genetic report showing an MT-TT variant, consult a neurologist or genetic counselor to discuss personalized risk management and next steps.
Limitations
- ⚠This test detects variants only in the MT-TT gene and does not rule out all genetic or non-genetic causes of Parkinson's disease.
- ⚠Variants of uncertain significance (VUS) may be reported; additional testing of family members may be required.
- ⚠A negative result does not exclude the presence of Parkinson's disease, as the condition is multifactorial.
- ⚠This test is not intended for prenatal diagnosis or predictive testing in asymptomatic minors without prior genetic counseling.
Risks & Considerations
- ●Minimal bleeding, bruising, or infection at the blood draw site
- ●Emotional or psychological distress from learning genetic risk information
- ●Potential privacy concerns regarding genetic data; DNA Labs India follows strict confidentiality protocols
Interfering Factors
- ●Sample contamination with non-mitochondrial DNA
- ●Degraded or low-quality DNA
- ●Presence of nuclear mitochondrial DNA sequences (NUMTs)
Frequently Asked Questions
What is the MT-TT gene and how is it related to Parkinson's disease?
Who should consider the MT-TT NGS genetic test?
How is the MT-TT NGS genetic test performed?
What does a positive result mean?
What does a negative result mean?
What is the cost of the MT-TT NGS genetic test at DNA Labs India?
How long does it take to get the test report?
Is fasting required before the MT-TT genetic test?
Does DNA Labs India offer home sample collection for this test?
Will I receive raw data files and FASTQ/VCF files?
How is this test different from other Parkinson's genetic tests?
Is genetic counseling available after the test?
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