Skip to main content
DNA Labs India

NDE1 Gene Lissencephaly type 4 with microcephaly NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NDE1 Gene Lissencephaly type 4 with microcephaly NGS Genetic Test

Short Name: NDE1 Genetic Test

Also known as: NDE1 Gene Test, Lissencephaly Type 4 Genetic Test, Microcephaly NGS Test

NDE1 Gene Lissencephaly type 4 with microcephaly NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing Genetic TestPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the NDE1 gene that cause lissencephaly type 4 with microcephaly, enabling accurate diagnosis, genetic counseling, and informed management of the condition.

Test Code
1671
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Ensure proper genetic counseling session and pedigree chart preparation. No specific preparation required, but maintain sample integrity.

Method: Venipuncture or Finger Prick

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or finger prick for FTA card. Follow aseptic techniques.

Step 3

Report Delivery

Sample stored at ambient room temperature. Transport to lab promptly for analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and pedigree chart preparation are recommended. No fasting required.
2
During the Test:Blood sample collection is a simple procedure with minimal discomfort.
3
After the Test:Monitor for any signs of infection or bruising at the collection site. Await reports as per timeline.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the NDE1 gene that cause lissencephaly type 4 with microcephaly, enabling accurate diagnosis, genetic counseling, and informed management of the condition.

How to Prepare

  • Use EDTA tube for blood samples or FTA card for one drop blood
  • Label samples correctly with patient details
  • Avoid hemolysis during collection
  • Store at room temperature before processing

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for NDE1 mutations is crucial for accurate diagnosis and timely intervention in lissencephaly type 4 with microcephaly, aiding in management and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL
ContainerEDTA Tube or FTA Card
Collection MethodVenipuncture or Finger Prick

Sample Stability

Blood sample stable for 48 hours at room temperature
FTA card stable for extended periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or contamination

Understanding Your Results

Results indicate whether pathogenic variants in the NDE1 gene are detected, which are linked to lissencephaly type 4 with microcephaly.
📊

Pathogenic variant detected

Confirms diagnosis of lissencephaly type 4 with microcephaly due to NDE1 mutation. Genetic counseling and management recommended.

📊

No pathogenic variant detected

NDE1 gene mutation not found; condition may be due to other genetic or environmental factors. Clinical correlation advised.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

If your child shows symptoms like delayed development, seizures, or microcephaly, consult a neurologist or geneticist immediately for evaluation and possible testing.

Limitations

  • ⚠May not detect all possible mutations in the NDE1 gene
  • ⚠False negatives can occur due to technical limitations
  • ⚠Results require clinical correlation and genetic counseling

Risks & Considerations

  • ●Minor bruising or pain at blood draw site
  • ●Rare risk of infection
  • ●Emotional stress from genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Frequently Asked Questions

What is NDE1 Gene Lissencephaly Type 4?
It is a rare neurological disorder caused by mutations in the NDE1 gene, leading to a smooth brain surface and microcephaly in infants.
What are the common symptoms of this condition?
Symptoms include developmental delays, seizures, poor muscle tone, coordination issues, intellectual disability, and brain abnormalities.
How is lissencephaly type 4 diagnosed?
Diagnosis is made through genetic testing, such as NGS, to identify NDE1 mutations, often supported by brain imaging like MRI or CT scans.
What does the NGS Genetic Test involve?
It uses Next-Generation Sequencing to analyze the NDE1 gene for mutations from a blood or DNA sample.
What is the cost of this test at DNA Labs India?
The cost is INR 20000, with free home sample collection available across India.
Is home sample collection available?
Yes, DNA Labs India offers free home collection for online bookings in numerous cities nationwide.
How long does it take to get test results?
Reports are typically delivered within 3 to 4 weeks after sample receipt.
What sample is required for the test?
A blood sample, extracted DNA, or one drop of blood on an FTA card is needed.
Is fasting required before the test?
No, fasting is not required for this genetic test.
What do the test results indicate?
Results show whether pathogenic variants in the NDE1 gene are detected, confirming diagnosis if present.
Are there any risks associated with the test?
Risks are minimal, such as minor bruising from blood draw. Genetic counseling is recommended for emotional support.
What is the accuracy rate of this genetic test?
NGS-based genetic tests have high accuracy, typically over 99%, but results should be interpreted in clinical context with genetic counseling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Angelman Syndrome Test

₹10,000

Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test

₹14,000

Episodic Ataxia Type 1 Hotspot Test

₹11,500

Episodic Ataxia Comprehensive Profile Hotspot Test

₹16,000

Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test

₹7,500

Analyzer 18 SMA 18 Test Panel

₹1,755
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.