NDN Gene Prader-Willi syndrome NGS Genetic Test
Short Name: NDN PWS NGS Test
Also known as: NDN Gene Sequencing, Prader-Willi Syndrome NGS Panel, Necdin Gene Test
NDN Gene Prader-Willi syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood, Extracted DNA, or FTA Card blood spot samples. Results in Reports are typically available within 3-4 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of the NDN Gene Prader-Willi Syndrome NGS Genetic Test is to confirm or exclude the clinical diagnosis of Prader-Willi Syndrome by detecting sequence variants in the NDN gene. It is also useful for identifying carriers in families and for genetic counseling.
- Test Code
- 4486
- ICD Code
- Q87.1
- Price
- ₹20,000
- Sample Type
- Blood, Extracted DNA, or FTA Card blood spot
- Result Time
- Reports are typically available within 3-4 weeks after sample collection.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting or special preparation is required. Please inform the laboratory about any known genetic condition in the family.
Method: Peripheral venipuncture or FTA card blood spot
Laboratory Analysis
A peripheral blood sample is collected by venipuncture. For infants, a few drops of blood may be collected on an FTA card. The procedure is safe and takes only a few minutes.
Report Delivery
No restrictions. The sample will be sent to the laboratory for analysis. You can resume normal activities immediately.
Timeline: Reports are typically available within 3-4 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the NDN Gene Prader-Willi Syndrome NGS Genetic Test is to confirm or exclude the clinical diagnosis of Prader-Willi Syndrome by detecting sequence variants in the NDN gene. It is also useful for identifying carriers in families and for genetic counseling.
How to Prepare
- For blood sample: collect in an EDTA vacutainer to prevent clotting.
- For FTA card: apply 3-4 drops of blood onto the labeled card and air dry for 1 hour.
- Ensure the patient's name, date of birth, and collection date are clearly written on the label.
- Transport the sample to the laboratory within 48 hours at room temperature.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Early genetic testing is crucial in Prader-Willi syndrome, as prompt intervention with growth hormone and nutrition management can significantly improve developmental outcomes. I recommend genetic counseling for all families undergoing this test."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Insufficient sample volume
- Mislabeled or unlabeled sample
- Sample received after excessive delay (more than 48 hours without cooling)
Understanding Your Results
Pathogenic variant detected
This indicates a molecular diagnosis of Prader-Willi syndrome. Genetic counseling is recommended for the family and to discuss management options.
No pathogenic variant detected
This reduces the likelihood of PWS caused by NDN gene variants. Other tests such as methylation analysis or chromosomal microarray may be considered.
Variant of uncertain significance (VUS) detected
The clinical significance is unknown. Further family studies and functional analysis may be needed to clarify its role.
If you have any concerns about your child's development, feeding, or growth patterns, or if there is a known family history of Prader-Willi syndrome, please consult a pediatrician or a medical geneticist for further evaluation.
Limitations
- ⚠Negative result does not rule out other genetic causes of PWS-like phenotype
- ⚠Variants of uncertain significance (VUS) may be reported
- ⚠Large rearrangements may require complementary testing such as MLPA or microarray
Risks & Considerations
- ●Minimal risk of bruising or discomfort at the blood draw site
- ●Psychological stress related to result interpretation
- ●Potential for unexpected genetic findings
Interfering Factors
- ●Poor DNA quality or insufficient quantity
- ●Maternal cell contamination in sample
- ●Very large deletions may not be detected by standard NGS analysis
Frequently Asked Questions
What is the NDN Gene Prader-Willi Syndrome NGS Genetic Test?
Who should undergo this test?
What is the cost of the NDN gene PWS NGS test at DNA Labs India?
What type of sample is required?
Is fasting required before the test?
How long does it take to get the report?
What is the accuracy of this NGS test?
Does DNA Labs India provide raw data files?
Can this test detect all types of Prader-Willi syndrome?
How is Prader-Willi syndrome managed?
Can this test be performed on a newborn?
How can I book the NDN Gene PWS NGS test at DNA Labs India?
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