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NECAP1 Gene Early infantile epileptic encephalopathy type 21 NGS Genetic Test

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NECAP1 Gene Early infantile epileptic encephalopathy type 21 NGS Genetic Test

Short Name: EIEE21 NGS Test

Also known as: EIEE21, NECAP1-related encephalopathy, NECAP1 gene test

NECAP1 Gene Early infantile epileptic encephalopathy type 21 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample collection. Free home collection in 300+ cities across India.

NGS Genetic TestInfants and Children🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the NECAP1 Gene EIEE21 NGS Genetic Test is to accurately diagnose Early Infantile Epileptic Encephalopathy Type 21 by identifying pathogenic mutations in the NECAP1 gene. This helps in confirming the disorder, guiding treatment strategies, and offering genetic counseling to families.

Test Code
1595
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample collection
Fasting Required
No
Method
Next Generation Sequencing (NGS) Technology
Step 1

Sample Collection

Genetic counseling session recommended to draw a pedigree chart and discuss clinical history.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture with proper identification and handling.

Step 3

Report Delivery

Sample transported to the lab under ambient temperature for NGS analysis.

Timeline: 3 to 4 weeks from sample collection

Patient Instructions

1
Before the Test:Genetic counseling and informed consent are essential. Provide detailed clinical history.
2
During the Test:Sample collection and NGS analysis performed in the lab.
3
After the Test:Report generation and genetic counseling to discuss results and implications.

About This Test

Who Should Get This Test

The purpose of the NECAP1 Gene EIEE21 NGS Genetic Test is to accurately diagnose Early Infantile Epileptic Encephalopathy Type 21 by identifying pathogenic mutations in the NECAP1 gene. This helps in confirming the disorder, guiding treatment strategies, and offering genetic counseling to families.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection tubes
  • Avoid hemolysis during blood draw
  • Store sample at room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early diagnosis through genetic testing is crucial for managing EIEE21, guiding treatment options, and providing genetic counseling to affected families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for NGS analysis
ContainerEDTA tube for blood samples
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Incorrectly labeled samples
  • Insufficient sample volume

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the NECAP1 gene, which are associated with EIEE21.
Positive result: Pathogenic variant detected, consistent with EIEE21 diagnosis
Negative result: No pathogenic variants found; clinical correlation needed
Variant of uncertain significance: Requires further evaluation and family studies
⚠️ When to Consult a Doctor:

If symptoms such as seizures or developmental delays persist, consult a neurologist or geneticist for comprehensive evaluation and management.

Limitations

  • ⚠May not detect all genetic variants in NECAP1 gene
  • ⚠Does not rule out other causes of epileptic encephalopathy
  • ⚠Results require correlation with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic test results

Interfering Factors

  • ●Sample contamination
  • ●Insufficient DNA quantity
  • ●Hemolyzed blood samples

Compare With Similar Tests

TestNECAP1 Gene Early infantile epileptic encephalopathy type 21 NGS Genetic TestSCN1A Gene Test for Dravet SyndromeCDKL5 Gene TestSTXBP1 Gene TestGenetic Epilepsy Panel
ComparisonNECAP1 Gene Early infantile epileptic encephalopathy type 21 NGS Genetic Test

Frequently Asked Questions

What is NECAP1 Gene Early Infantile Epileptic Encephalopathy Type 21?
EIEE21 is a rare genetic disorder caused by mutations in the NECAP1 gene, leading to seizures, developmental delays, and intellectual disability in infants.
Who should consider this genetic test?
Infants and children with frequent seizures, developmental delays, or family history of epilepsy should consider this test for accurate diagnosis.
How is the test performed?
The test uses Next Generation Sequencing (NGS) to analyze the NECAP1 gene from a blood or DNA sample, identifying pathogenic mutations.
What is the cost of the NECAP1 Gene NGS Test?
The test costs INR 20,000, which includes sample collection, analysis, and report generation.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across India in numerous cities.
How long does it take to get results?
Results are typically available within 3 to 4 weeks from sample collection.
What do the test results indicate?
Results show if pathogenic variants in the NECAP1 gene are present, helping diagnose EIEE21 and guide treatment.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising. Genetic results may have psychological impacts, so counseling is recommended.
Can the test detect all causes of epilepsy?
No, this test specifically targets the NECAP1 gene. Other causes of epilepsy may require different tests or panels.
Is genetic counseling provided?
Yes, DNA Labs India provides genetic counseling sessions to discuss results and implications for families.
What should I do before getting tested?
Consult a healthcare provider, provide clinical history, and undergo genetic counseling to draw a family pedigree chart.
Is the test covered by insurance in India?
Coverage depends on insurance schemes like PMJAY, CGHS, etc. It is recommended to check with your provider for eligibility.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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