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NFKB2 Gene Immunodeficiency common variable type 10 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NFKB2 Gene Immunodeficiency common variable type 10 NGS Genetic Test

Also known as: CVID10, NFKB2-related immunodeficiency

NFKB2 Gene Immunodeficiency common variable type 10 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the NFKB2 gene that cause Immunodeficiency Common Variable Type 10. It aids in confirming diagnosis, guiding treatment decisions, and facilitating genetic counseling for families.

Test Code
2416
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide clinical history of the patient and undergo genetic counseling to draw a pedigree chart of affected family members.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample will be collected via venipuncture or using an FTA card for one drop of blood.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store sample as instructed.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are recommended before testing.
2
During the Test:The test involves NGS analysis of the NFKB2 gene from the provided sample.
3
After the Test:Results will be available in 3 to 4 weeks. Follow-up with a healthcare provider is advised.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the NFKB2 gene that cause Immunodeficiency Common Variable Type 10. It aids in confirming diagnosis, guiding treatment decisions, and facilitating genetic counseling for families.

How to Prepare

  • Use sterile equipment
  • Label sample correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This NGS test is essential for confirming diagnosis in patients with suspected primary immunodeficiency, allowing for targeted therapy and genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of mutations in the NFKB2 gene associated with Immunodeficiency Common Variable Type 10.
📊

Positive for pathogenic variant

Confirms diagnosis of NFKB2-related immunodeficiency. Consult a geneticist for management.

📊

Negative

No pathogenic variants detected. Clinical correlation recommended.

📊

Variant of uncertain significance

Further testing and family studies may be needed.

⚠️ When to Consult a Doctor:

If the test is positive or if there are clinical symptoms suggestive of immunodeficiency, consult an immunologist or geneticist immediately.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results require clinical correlation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection

Interfering Factors

  • ●Poor sample quality
  • ●Contamination during collection

Frequently Asked Questions

What is NFKB2 Gene Immunodeficiency Common Variable Type 10?
It is a rare genetic disorder caused by mutations in the NFKB2 gene, leading to impaired immune function and recurrent infections.
What are the symptoms of this disorder?
Symptoms include recurrent infections, autoimmune disorders, lymphoproliferative disorders, delayed wound healing, chronic diarrhea, failure to thrive, and low immunoglobulin levels.
How is the disorder diagnosed?
Diagnosis is confirmed through genetic testing, such as the NFKB2 Gene NGS Genetic Test offered by DNA Labs India.
What is the cost of the test?
The test costs INR 20000, which includes sample collection, transportation, testing, and interpretation.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection across India for this test.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted.
How long does it take to get results?
Results are typically available in 3 to 4 weeks.
What should I do before the test?
Provide clinical history and undergo genetic counseling to draw a family pedigree chart.
What does a positive result mean?
A positive result confirms the presence of a pathogenic mutation in the NFKB2 gene, indicating the disorder. Consult a geneticist for management.
Is the test covered by insurance?
Coverage depends on the insurance provider. Check with your insurer for details.
Are there any risks associated with the test?
The test involves a blood draw, which has minimal risks such as bruising or infection.
Can this test be used for prenatal diagnosis?
This test is for postnatal diagnosis. For prenatal testing, consult a genetic counselor for appropriate options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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