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DNA Labs India

NGF Gene HSAN5 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NGF Gene HSAN5 NGS Genetic Test

Short Name: NGF HSAN5 NGS

Also known as: HSAN5 Genetic Test, NGF Gene Mutation Analysis, Hereditary Sensory Neuropathy Type V Genetic Test

NGF Gene HSAN5 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The test aims to identify mutations in the NGF gene that are associated with HSAN5, aiding in definitive diagnosis and enabling appropriate management and genetic counseling for affected families.

Test Code
4137
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. Please share relevant clinical history and family pedigree with the attending clinician.

Method: Blood draw or FTA card

Step 2

Laboratory Analysis

A small blood sample will be collected by a trained phlebotomist or via FTA card (one drop of blood).

Step 3

Report Delivery

No specific post-collection precautions. Resume normal activities.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Pre-test genetic counseling is recommended to discuss risks and benefits. A clinical history and pedigree chart should be prepared.
2
During the Test:The sample is collected in a simple procedure. No fasting or anesthesia required.
3
After the Test:You will receive the report via email/WhatsApp within 3-4 weeks. Please contact your clinician for result interpretation.

About This Test

Who Should Get This Test

The test aims to identify mutations in the NGF gene that are associated with HSAN5, aiding in definitive diagnosis and enabling appropriate management and genetic counseling for affected families.

How to Prepare

  • If using blood: collect in an EDTA vacutainer.
  • If using FTA card: apply a single drop of blood to the marked area and allow to dry.
  • Ensure sample is labeled with patient name and other identifiers.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic confirmation of HSAN5 is essential for accurate prognosis, family planning decisions, and management of complications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw or FTA card

Sample Stability

Whole blood: 48 hours at 2-8°C
Extracted DNA: 1 week at -20°C
FTA card at room temperature: up to 3 months
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labelled samples
  • Samples received after prolonged transport time without proper storage

Understanding Your Results

Results are interpreted by a molecular geneticist and reviewed by a clinical geneticist. Findings are classified as per ACMG guidelines.
Pathogenic mutation detected: Confirms the diagnosis of HSAN5, if symptoms correlate.
No pathogenic mutation detected: Does not exclude HSAN5; other genetic etiologies should be explored.
Variant of uncertain significance (VUS): Requires further segregation analysis and functional studies.
⚠️ When to Consult a Doctor:

If your test result is positive or if you have a family history of HSAN5, consult a neurologist or genetic specialist for management and genetic counseling.

Limitations

  • ⚠This test detects mutations only in the NGF gene. Mutations in other genes may cause similar phenotypes.
  • ⚠Clinical correlation and genetic counseling are recommended for accurate interpretation.
  • ⚠Negative results do not completely rule out HSAN5 if there is strong clinical suspicion; other genetic causes should be considered.

Risks & Considerations

  • ●The test is safe with minimal risks such as mild pain or bruising at the phlebotomy site.

Interfering Factors

  • ●Low DNA quality or quantity may affect test performance.
  • ●Genetic variants of uncertain significance (VUS) may be reported and require further family studies.

Compare With Similar Tests

TestNGF Gene HSAN5 NGS Genetic TestPeripheral Neuropathy NGS PanelTargeted NGF Gene Sanger Sequencing
ComparisonNGF Gene HSAN5 NGS Genetic Test

Frequently Asked Questions

What is the NGF Gene HSAN5 NGS Genetic Test?
This is a targeted next-generation sequencing test that analyzes the NGF gene for mutations associated with Hereditary Sensory and Autonomic Neuropathy Type 5 (HSAN5). It helps confirm a diagnosis of HSAN5.
How is HSAN5 inherited?
HSAN5 is generally inherited in an autosomal recessive manner, meaning a person must inherit two mutated copies of the NGF gene, one from each parent.
What are the common symptoms of HSAN5?
Symptoms include loss of sensation in the feet and hands, muscle weakness, balance and coordination difficulties, scoliosis, reduced sweating, and slow wound healing.
Who should consider taking this test?
Individuals with symptoms suggestive of HSAN5, those with a family history of HSAN5, or people seeking confirmation of a clinical diagnosis may consider this test.
What type of sample is required?
You can provide a blood sample (collected at a lab or home visit) or one drop of blood on an FTA card. Extracted DNA is also acceptable.
Is fasting required before the test?
No, fasting is not required for this genetic test. It can be done at any time of the day.
How long does it take to get the report?
The turnaround time is 3 to 4 weeks, as the NGS process involves complex analysis and interpretation.
What does the test report include?
The report includes the genetic test findings, an interpretation by a clinical geneticist, and, at DNA Labs India, raw data files (FASTQ and VCF) for transparency.
Are there any risks associated with this test?
The test is very safe. The only risk may be minor discomfort or bruising during blood collection.
What is the cost of the NGF Gene HSAN5 NGS Genetic Test?
The test costs INR 20,000 at DNA Labs India, and free home sample collection is provided for online bookings.
How will I receive my results?
Results are sent through our online portal, email, or WhatsApp as per your preference.
Is home sample collection available across India?
Yes, we offer free home sample collection for this test in over 150 major cities across India, including Mumbai, Delhi, Bangalore, Hyderabad, and Chennai.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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