NLGN3 Gene Asperger Syndrome Susceptibility X-Linked Type 2 NGS Genetic Test
Short Name: NLGN3 Gene Test
Also known as: NLGN3 Gene Asperger Syndrome Test, X-linked Asperger Syndrome Genetic Test, Neuroligin 3 Gene Test
NLGN3 Gene Asperger Syndrome Susceptibility X-Linked Type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the NLGN3 Gene Asperger Syndrome Susceptibility X-Linked Type 2 NGS Genetic Test is to identify genetic variations in the NLGN3 gene that may increase susceptibility to Asperger Syndrome. This test serves as a diagnostic tool for individuals exhibiting symptoms and for carrier testing in families with a history of the condition, especially relevant for X-linked inheritance. It supports clinical decision-making, early intervention, and genetic counseling.
- Test Code
- 1511
- ICD Code
- F84.5
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
A genetic counseling session is recommended to discuss clinical history, pedigree chart, and test implications. No fasting is required.
Method: Venipuncture or FTA card application
Laboratory Analysis
Standard venipuncture for blood collection or application of one drop blood on FTA card. For extracted DNA, provide in appropriate buffer.
Report Delivery
Sample is processed for DNA extraction and NGS analysis. Reports are generated and delivered in 3 to 4 weeks.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the NLGN3 Gene Asperger Syndrome Susceptibility X-Linked Type 2 NGS Genetic Test is to identify genetic variations in the NLGN3 gene that may increase susceptibility to Asperger Syndrome. This test serves as a diagnostic tool for individuals exhibiting symptoms and for carrier testing in families with a history of the condition, especially relevant for X-linked inheritance. It supports clinical decision-making, early intervention, and genetic counseling.
How to Prepare
- For blood: Collect 5-10 ml in an EDTA tube under aseptic conditions.
- For FTA card: Apply one drop of blood and let it dry completely before packaging.
- For extracted DNA: Ensure DNA is dissolved in TE buffer or similar, with concentration >50 ng/µl.
- Label samples clearly with patient details and transport at ambient room temperature.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is vital for identifying genetic susceptibility to Asperger Syndrome, aiding in early intervention and family planning, especially for carrier females in X-linked cases."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Incorrect sample type or container
- Missing patient identification or consent
Understanding Your Results
Positive for Pathogenic Variant
Indicates a genetic change in NLGN3 that may increase risk for Asperger Syndrome. Supports diagnosis and informs family screening.
Negative for Pathogenic Variant
No known pathogenic variants detected in NLGN3. Does not rule out other genetic or environmental causes.
Variant of Uncertain Significance (VUS)
Genetic change identified but clinical significance is unclear. Recommend clinical correlation and potential reanalysis.
Consult a healthcare professional if you or a family member exhibit symptoms of Asperger Syndrome, such as social interaction difficulties or repetitive behaviors. Also, consult for genetic counseling if there is a family history of the condition or for carrier testing purposes.
Limitations
- ⚠This test only detects variants in the NLGN3 gene; other genetic or environmental factors may contribute to Asperger Syndrome.
- ⚠Negative result does not completely rule out genetic susceptibility, as not all causative variants are known.
- ⚠Results should be interpreted in conjunction with clinical evaluation and family history.
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or discomfort at the puncture site.
- ●Emotional impact of genetic results, requiring psychological support.
- ●No significant physical risks associated with the test itself.
Interfering Factors
- ●Sample contamination during collection or transport
- ●Insufficient DNA quantity or quality
- ●Hemolyzed or degraded blood samples
- ●Recent blood transfusions may affect DNA analysis
Frequently Asked Questions
What is the NLGN3 Gene Asperger Syndrome Susceptibility Test?
How is the test performed?
What sample is required for the test?
How long does it take to get results?
What is the cost of the test?
Is the test covered by insurance?
Can the test be used for carrier testing?
What are the symptoms of Asperger Syndrome?
How accurate is the NGS genetic test?
What should I do if the test result is positive?
Is genetic counseling required before the test?
Does DNA Labs India provide raw data and files?
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