NLGN3 Gene Autism Susceptibility, X-Linked Type 1 NGS Genetic Test
Short Name: NLGN3 Gene Autism Susceptibility NGS
Also known as: NLGN3 Gene Mutation Analysis, Neuroligin 3 Gene Sequencing, X-Linked Autism Susceptibility Genetic Test
NLGN3 Gene Autism Susceptibility, X-Linked Type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood / Extracted DNA / One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To identify clinically significant mutations in the NLGN3 gene using next-generation sequencing, supporting the genetic diagnosis of X-linked type 1 autism susceptibility, enabling risk assessment, and helping affected families with genetic counseling.
- Test Code
- 3906
- Price
- ₹20,000
- Sample Type
- Blood / Extracted DNA / One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. Inform your doctor about current medications and provide a clear clinical history, including any family history of autism or neurodevelopmental disorders. A genetic counselling session before the test is recommended.
Method: Venipuncture / FTA card blood spot
Laboratory Analysis
A small blood sample is drawn from a vein by a trained phlebotomist, or one drop of blood is placed on an FTA card for convenient collection.
Report Delivery
The sample is sent to the laboratory within the recommended timeframe. You may resume normal activities immediately after collection.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
To identify clinically significant mutations in the NLGN3 gene using next-generation sequencing, supporting the genetic diagnosis of X-linked type 1 autism susceptibility, enabling risk assessment, and helping affected families with genetic counseling.
How to Prepare
- Use an EDTA vacutainer for whole blood collection
- For FTA card, apply one drop of blood and let it air dry
- Label the sample correctly with patient name, date, and time
- Transport the sample to the laboratory at room temperature as per instructions
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"A genetic test for NLGN3 is most useful when paired with detailed clinical phenotyping and a three-generation pedigree. In females, X-linked inheritance and inactivation patterns can complicate risk interpretation; referral to a clinical geneticist is strongly advised."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted blood sample
- Hemolyzed sample
- Insufficient sample volume
- Unlabeled or mislabeled sample
- Sample received without consent form or clinical history
Understanding Your Results
No pathogenic variant detected
No disease-causing change found in the NLGN3 gene. Clinical correlation with other genetic or non-genetic causes is recommended.
Pathogenic variant detected
A disease-causing NLGN3 variant is present; consistent with increased susceptibility to X-linked type 1 autism. Genetic counseling and family screening are advised.
Variant of uncertain significance (VUS)
A genetic variant was found, but its clinical significance is not yet clear. Additional family studies and specialty review may be needed.
Consult a neurologist, pediatrician, psychiatrist, or genetic counselor if you notice early signs of autism, have a confirmed family history of X-linked autism or intellectual disability, or receive a VUS/pathogenic result and need personalized risk assessment.
Limitations
- ⚠This test covers the NLGN3 gene only and does not exclude other genetic causes of autism
- ⚠A negative result does not rule out a clinical diagnosis of autism or a non-genetic cause
- ⚠NGS may not detect all structural variants, repeat expansions, or large deletions/duplications
- ⚠Results must be interpreted in the context of clinical findings, family history, and genetic counseling
Risks & Considerations
- ●Minimal risk of bruising at the blood draw site
- ●Dizziness or fainting during blood collection
- ●No significant metabolic or allergic risks associated with this test
Interfering Factors
- ●DNA quality and quantity may affect sequencing performance
- ●Low-level mosaicism may not be detected by standard NGS
- ●Variants in non-coding or deep intronic regions may be missed
- ●A variant of uncertain significance requires family segregation analysis
Compare With Similar Tests
| Test | NLGN3 Gene Autism Susceptibility, X-Linked Type 1 NGS Genetic Test | ||
|---|---|---|---|
| Comparison | NLGN3 Gene Autism Susceptibility, X-Linked Type 1 NGS Genetic Test |
Frequently Asked Questions
What is the cost of the NLGN3 gene autism susceptibility NGS test in India?
What is the NLGN3 gene?
What sample is required for the NLGN3 NGS genetic test?
How is the NLGN3 gene tested?
How long will my NLGN3 genetic test reports take?
Does this genetic test diagnose autism?
Who should consider the NLGN3 gene autism susceptibility test?
Does this test detect mutations in other autism-related genes?
Are there any risks associated with the test?
Will insurance cover the NLGN3 genetic test?
Can I get the raw data files with the test report?
Is genetic counseling recommended with this test?
Related Tests
Angelman Syndrome Test
₹10,000Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test
₹14,000Episodic Ataxia Type 1 Hotspot Test
₹11,500Episodic Ataxia Comprehensive Profile Hotspot Test
₹16,000Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test
₹7,500Analyzer 18 SMA 18 Test Panel
₹1,755Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.