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NOS3 Gene Alzheimer Disease Type 1 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NOS3 Gene Alzheimer Disease Type 1 NGS Genetic Test

Short Name: NOS3 Alzheimer NGS Test

Also known as: NOS3 Gene Mutation NGS Test, Alzheimer Disease Type 1 Genetic Test, eNOS Gene Alzheimer's Test

NOS3 Gene Alzheimer Disease Type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) – targeted gene panel, Sanger sequencing for variant confirmation on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports will be available within 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS (Next-Generation Sequencing)Adult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of the NOS3 Gene Alzheimer Disease Type 1 NGS Genetic Test is to detect pathogenic mutations in the NOS3 gene that are associated with early-onset Alzheimer's disease type 1. It supports clinical diagnosis, helps identify at-risk family members, and assists in early therapeutic planning.

Test Code
3865
ICD Code
G30.0
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports will be available within 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS) – targeted gene panel, Sanger sequencing for variant confirmation
Step 1

Sample Collection

No fasting is required. A genetic counseling session is recommended prior to testing. Bring family history, previous test reports, and doctor's referral.

Method: Venipuncture or Finger-prick (FTA card)

Step 2

Laboratory Analysis

Blood sample will be collected by a trained phlebotomist. For FTA card, a simple finger-prick blood spot is applied.

Step 3

Report Delivery

No special precautions. Resume normal activities. The sample will be transported to the laboratory for analysis.

Timeline: Reports will be available within 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:No fasting is required. A genetic counseling session is recommended prior to testing. Bring family history, previous test reports, and doctor's referral.
2
During the Test:Blood sample will be collected by a trained phlebotomist. For FTA card, a simple finger-prick blood spot is applied.
3
After the Test:No special precautions. Resume normal activities. The sample will be transported to the laboratory for analysis.

About This Test

Who Should Get This Test

The purpose of the NOS3 Gene Alzheimer Disease Type 1 NGS Genetic Test is to detect pathogenic mutations in the NOS3 gene that are associated with early-onset Alzheimer's disease type 1. It supports clinical diagnosis, helps identify at-risk family members, and assists in early therapeutic planning.

How to Prepare

  • For blood sample: Use an EDTA vacutainer, collect 1-2 ml of peripheral blood.
  • For extracted DNA: 3-5 µl of high-quality DNA (NanoDrop ≥1.8, no degradation).
  • For FTA card: Apply one drop of blood onto the FTA card, allow to dry, and store in a protective pouch.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early-onset Alzheimer's disease can have a strong genetic basis. Identifying a pathogenic NOS3 variant may support clinical diagnosis and guide family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume1-2 ml blood or 3-5 µl extracted DNA
ContainerEDTA vacutainer or FTA card
Collection MethodVenipuncture or Finger-prick (FTA card)

Sample Stability

Whole blood in EDTA: 24-48 hours at room temperature; do not refrigerate.
FTA card: stable for up to 6 months at ambient temperature.
Extracted DNA: stable for 1 week at 4°C or long-term at -20°C.
Sample Rejection Criteria:
  • Hemolyzed, clotted, or frozen whole blood
  • Insufficient sample quantity
  • Improperly labeled sample
  • Samples received without signed requisition or clinical history

Understanding Your Results

The clinical report will state whether a pathogenic or likely pathogenic variant was identified in the NOS3 gene. A negative result does not rule out non-genetic causes of dementia.
Positive (pathogenic variant detected): Indicates the presence of a NOS3 variant that may contribute to Alzheimer disease type 1. Genetic counseling and family testing are recommended.
Negative (no pathogenic variant detected): Reduces the likelihood of NOS3-related early-onset Alzheimer disease. However, other genetic and non-genetic causes may still be present.
Variant of Uncertain Significance (VUS): A variant was found, but its clinical significance is currently unknown. Additional family studies may be needed.
⚠️ When to Consult a Doctor:

Consult a neurologist or genetic specialist before and after the test to understand the implications of your results, especially for presymptomatic or family testing.

Limitations

  • ⚠NGS does not detect all types of genetic changes (e.g., large deletions or structural rearrangements).
  • ⚠Variants of uncertain significance (VUS) may be identified; their clinical impact is not fully understood.
  • ⚠A negative result does not rule out other genetic or non-genetic causes of dementia.
  • ⚠This test is not intended for late-onset sporadic Alzheimer's disease risk assessment.

Risks & Considerations

  • ●There are no significant physical risks associated with blood collection.
  • ●Psychological and social implications from genetic information may occur; hence, genetic counseling is recommended.

Interfering Factors

  • ●Sample contamination
  • ●Degraded or low-quality DNA
  • ●Incomplete clinical information
  • ●Large deletions or duplications not detectable by NGS

Frequently Asked Questions

What is the NOS3 gene?
The NOS3 gene (endothelial nitric oxide synthase or eNOS) provides instructions for making an enzyme that produces nitric oxide. Nitric oxide helps regulate blood flow in the brain and protects against oxidative stress.
How is NOS3 linked to Alzheimer's disease type 1?
Mutations in NOS3 can reduce nitric oxide production, impairing cerebral blood flow and increasing vulnerability to neuronal damage. This has been associated with early-onset Alzheimer's disease type 1.
What is Alzheimer disease type 1?
Alzheimer disease type 1 is a rare, early-onset form of the disease that usually appears before age 60. It has a strong genetic component and can run in families.
Who should get this NGS genetic test?
This test is recommended for individuals with early-onset dementia, a family history of early-onset Alzheimer's disease, or unexplained cognitive decline before age 60. It should be done after genetic counseling.
How is the sample collected?
The sample can be collected by venipuncture (blood in EDTA tube) or by a finger-prick blood spot on an FTA card. Extracted DNA can also be submitted.
Do I need to fast before the test?
No. Fasting is not required for this genetic test.
When will I get the report?
The report is typically available within 3 to 4 weeks after the sample is received by the laboratory.
What is the cost of the test?
The cost of the NOS3 Gene Alzheimer Disease Type 1 NGS Genetic Test at DNA Labs India is Rs 20000.
Does home sample collection cost extra?
No. We offer free home sample collection for online bookings across India. The special discounted price of Rs 20000 includes this service.
What is the clinical relevance of a positive result?
A positive (pathogenic) finding indicates a genetic predisposition that may explain early-onset Alzheimer's disease. It supports the clinical diagnosis and enables testing of at-risk family members.
Is genetic counseling included?
Yes. A genetic counseling session to draw a pedigree chart of family members affected with the disease is included in the test process before sample collection.
Will I get raw data and VCF files?
Yes. DNA Labs India is transparent and will share raw data (FASTQ) and VCF files along with the conclusive clinical report, allowing independent verification.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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