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NOTCH3 Gene CADASIL NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

NOTCH3 Gene CADASIL NGS Genetic Test

Also known as: CADASIL Genetic Test, NOTCH3 Gene Mutation Test

NOTCH3 Gene CADASIL NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose CADASIL by detecting mutations in the NOTCH3 gene using NGS technology.

Test Code
5311
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with CADASIL.

Step 2

Laboratory Analysis

Your sample is analyzed using Next-Generation Sequencing (NGS) in our laboratory.

Step 3

Report Delivery

A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with CADASIL.

About This Test

Who Should Get This Test

To diagnose CADASIL by detecting mutations in the NOTCH3 gene using NGS technology.

How to Prepare

  • Blood sample: Collect in EDTA tube.
  • Extracted DNA: Provide in appropriate buffer.
  • FTA Card: One drop of blood on FTA card.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card

Understanding Your Results

Results indicate the presence or absence of mutations in the NOTCH3 gene associated with CADASIL.
Positive result: Mutation detected, consistent with CADASIL diagnosis.
Negative result: No mutation detected, but clinical correlation is advised.
Variant of uncertain significance: Further testing or family studies may be needed.
⚠️ When to Consult a Doctor:

If you experience symptoms such as recurrent strokes, migraines, or cognitive decline, especially with a family history of CADASIL.

Frequently Asked Questions

What is CADASIL?
CADASIL stands for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, a genetic disorder affecting brain blood vessels.
What causes CADASIL?
CADASIL is caused by mutations in the NOTCH3 gene, which is essential for blood vessel development and maintenance.
What are the symptoms of CADASIL?
Common symptoms include headaches, migraines, stroke-like symptoms, dementia, depression, seizures, vision problems, and balance issues.
How is CADASIL diagnosed?
Diagnosis involves clinical evaluation, brain imaging like MRI, and genetic testing to confirm NOTCH3 gene mutations.
What is NGS genetic testing?
Next-Generation Sequencing (NGS) is a technology that analyzes large amounts of genetic data quickly and accurately for diagnosing genetic disorders.
How much does the CADASIL genetic test cost?
The cost of the NOTCH3 Gene CADASIL NGS Genetic Test at DNA Labs India is INR 20,000.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What should I do before the test?
Provide your clinical history and undergo a genetic counseling session to draw a family pedigree chart.
Can CADASIL be treated?
There is no cure for CADASIL, but management focuses on symptom relief and preventing complications through medical care.
Is the test covered by insurance?
Coverage depends on your insurance plan; it is not universally covered. Check with your provider for details.
Who should consider this test?
Individuals with symptoms of CADASIL or a family history of the disorder should consider genetic testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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