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DNA Labs India

Notch3 Mutation Detection CADASIL Test

DNA Labs India | ISO 9001:2015 Certified

Notch3 Mutation Detection CADASIL Test

Short Name: CADASIL Genetic Test

Also known as: NOTCH3 Gene Test, CADASIL DNA Test, Hereditary Stroke Test

Notch3 Mutation Detection CADASIL Test test available at DNA Labs India for ₹13,000. Uses PCR, Sequencing on Whole Blood samples. Results in Results typically available within 5 business days.. Free home collection in 300+ cities across India.

Genetic Mutation DetectionAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations in the NOTCH3 gene for diagnosis of CADASIL, aiding in early intervention and family planning.

Test Code
1313
Price
₹13,000
Sample Type
Whole Blood
Result Time
Results typically available within 5 business days.
Fasting Required
No
Method
PCR, Sequencing
Step 1

Sample Collection

Ensure the Genomics Clinical Information Requisition Form (Form 20) is duly filled.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding.

Timeline: Results typically available within 5 business days.

Patient Instructions

1
Before the Test:Consult your doctor and complete necessary forms.
2
During the Test:Blood sample collection process.
3
After the Test:Wait for results and follow up with your healthcare provider.

About This Test

Who Should Get This Test

To detect mutations in the NOTCH3 gene for diagnosis of CADASIL, aiding in early intervention and family planning.

How to Prepare

  • Fasting not required
  • Complete Form 20
  • Sample must be refrigerated after collection

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CADASIL is essential for accurate diagnosis, especially in families with a history of stroke or neurological symptoms. It guides treatment and preventive measures."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood
Sample Volume4 mL (2 mL min.)
ContainerLavender Top (EDTA) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature
Refrigerated
Frozen
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Improperly labeled tube

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the NOTCH3 gene.
📊

No mutation detected

No evidence of CADASIL genetic mutation. Clinical correlation advised.

📊

Mutation detected

Positive for CADASIL mutation. Consult a genetic counselor and neurologist for management.

⚠️ When to Consult a Doctor:

If you experience symptoms like recurrent headaches, stroke, or have a family history of CADASIL.

Limitations

  • ⚠May not detect all variants
  • ⚠Requires clinical correlation
  • ⚠Not for prenatal diagnosis unless specified

Risks & Considerations

  • ●Minor pain or bruising at blood draw site
  • ●Rare infection risk

Interfering Factors

  • ●Hemolyzed blood sample
  • ●Recent blood transfusion

Compare With Similar Tests

TestNotch3 Mutation Detection CADASIL TestMRI BrainGenetic Counseling
ComparisonNotch3 Mutation Detection CADASIL TestMRI shows white matter lesions but does not confirm genetic mutation.Complements genetic testing for interpretation and family planning.

Frequently Asked Questions

What is CADASIL?
CADASIL is a rare genetic disorder affecting brain blood vessels, causing strokes and neurological symptoms.
What gene is involved in CADASIL?
The NOTCH3 gene mutation is responsible for CADASIL.
What are the common symptoms of CADASIL?
Symptoms include recurrent headaches, migraines with aura, stroke, dementia, and depression.
How is CADASIL diagnosed?
Diagnosis involves neurological exams, MRI scans, and genetic testing for NOTCH3 mutations.
What is the NOTCH3 Mutation Detection Test?
It is a blood test that detects mutations in the NOTCH3 gene to confirm CADASIL.
How is the test sample collected?
A blood sample is drawn from the arm and stored in an EDTA tube.
Is fasting required for the test?
No fasting is required, but the Genomics Clinical Information Requisition Form must be completed.
What is the cost of the CADASIL test?
The test costs INR 13,000 in India.
Is home collection available?
Yes, free home sample collection is offered for online bookings in many cities.
How long does it take to get results?
Results are typically available within 5 business days.
What does a positive test result mean?
A positive result indicates a mutation in the NOTCH3 gene, suggesting CADASIL. Consult a doctor for next steps.
Is there a treatment for CADASIL?
There is no cure, but symptoms can be managed with medications and lifestyle changes.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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