NTRK1 Gene HSAN4 NGS Genetic Test
Short Name: NTRK1 HSAN4 NGS
Also known as: HSAN4 Genetic Test, NTRK1 Gene Mutation Test, TrkA Gene Sequencing
NTRK1 Gene HSAN4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are delivered within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To detect pathogenic mutations in the NTRK1 gene that cause Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN4) using next-generation sequencing.
- Test Code
- 4128
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are delivered within 3 to 4 weeks from sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. A detailed clinical history and genetic counseling session to construct a family pedigree are necessary before testing.
Method: Blood draw or FTA card spot
Laboratory Analysis
An experienced phlebotomist will draw approximately 2 ml of blood into an EDTA vacutainer, or collect a single drop of blood on an FTA card.
Report Delivery
No restrictions. Patients can resume daily activities immediately.
Timeline: Reports are delivered within 3 to 4 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
To detect pathogenic mutations in the NTRK1 gene that cause Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN4) using next-generation sequencing.
How to Prepare
- Provide the patient's clinical history and consent form
- Use an EDTA vacutainer for blood collection or FTA card for dried blood spot
- Label the sample with patient name, ID, and date
- Transport at ambient temperature to the laboratory within 24 hours
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"NTRK1 gene testing is essential for confirming HSAN4 diagnosis in children with unexplained insensitivity to pain. It also helps families make informed reproductive decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood
- Inadequate blood volume
- FTA card with insufficient blood spots
- Sample leakage during transport
- Unlabeled or mislabeled sample
Understanding Your Results
No pathogenic variants detected
Negative for HSAN4-associated NTRK1 mutations
One pathogenic variant detected
Carrier state; individual is unaffected unless two variants present
Two pathogenic variants detected
Confirms diagnosis of HSAN4
Variant of uncertain significance (VUS)
Inconclusive; further segregation and functional studies may be needed
If you or your child exhibits unexplained reduced pain sensitivity, recurrent painless injuries, or a family history of hereditary neuropathy, consult a clinical geneticist or neurologist.
Limitations
- ⚠NGS may not reliably detect large deletions, duplications, or repeat expansions
- ⚠Variants in non-coding regions or regulatory elements may not be captured
- ⚠A variant of uncertain significance (VUS) may require additional testing
- ⚠Negative results do not completely exclude a genetic cause in other genes
Risks & Considerations
- ●Mild pain or bruising at blood draw site
- ●Dizziness during collection
- ●Rare infection at venipuncture site
Interfering Factors
- ●Insufficient DNA concentration
- ●Degraded DNA from improper storage
- ●PCR amplification errors
- ●Presence of maternal cell contamination in prenatal samples
Compare With Similar Tests
| Test | NTRK1 Gene HSAN4 NGS Genetic Test | |||
|---|---|---|---|---|
| Comparison | NTRK1 Gene HSAN4 NGS Genetic Test |
Frequently Asked Questions
What is HSAN4?
What is the cost of the NTRK1 Gene HSAN4 NGS Genetic Test at DNA Labs India?
What type of sample is required?
How long does this genetic test take?
Is home sample collection available for this test?
What is the inheritance pattern of HSAN4?
Who should undergo this genetic test?
Does this test require fasting?
Will I receive raw data files?
Are there any limitations of NGS-based genetic testing?
Can this test detect all causes of HSAN?
Is this test covered by insurance?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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