Nx Gen Sequencing: Amyotrophic Lateral Sclerosis Test
Short Name: ALS Genetic Test
Also known as: Lou Gehrig's Disease Genetic Test, ALS Sequencing Test
Nx Gen Sequencing: Amyotrophic Lateral Sclerosis Test test available at DNA Labs India for ₹23,400. Uses Next-Generation Sequencing (NGS), Sanger sequencing on Whole blood samples. Results in Report delivery within 40 working days from sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect genetic mutations linked to Amyotrophic Lateral Sclerosis (ALS) through comprehensive sequencing. It helps confirm diagnosis, determine hereditary risk, guide treatment strategies, and provide insights for family members regarding carrier status and potential disease manifestation.
- Test Code
- 1328
- Price
- ₹23,400
- Sample Type
- Whole blood
- Result Time
- Report delivery within 40 working days from sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS), Sanger sequencing
Sample Collection
Ensure the Whole Exome Sequencing Consent Form (Form 37) is duly filled and signed. No fasting is required, but inform the healthcare provider about any medications or recent medical procedures.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in the arm using standard venipuncture technique. The process typically takes 5-10 minutes.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Avoid strenuous activity with the arm for a few hours. Store the sample as per instructions: room temperature for 6 hours or refrigerated for up to 72 hours, but do not freeze.
Timeline: Report delivery within 40 working days from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect genetic mutations linked to Amyotrophic Lateral Sclerosis (ALS) through comprehensive sequencing. It helps confirm diagnosis, determine hereditary risk, guide treatment strategies, and provide insights for family members regarding carrier status and potential disease manifestation.
How to Prepare
- Submit 10 mL (5 mL min.) whole blood from 2 Lavender Top (EDTA) tubes
- Ship refrigerated; do not freeze
- Duly filled Whole Exome Sequencing Consent Form (Form 37) is mandatory
- Label samples with patient details and date of collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for ALS is crucial for early diagnosis, family planning, and personalized management. Consult a specialist for interpretation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume
- Improperly labeled or unlabeled tubes
- Missing or incomplete consent form
- Clotted or hemolyzed blood sample
- Use of non-EDTA containers
Understanding Your Results
Pathogenic variant detected
Indicates a genetic mutation linked to ALS, increasing risk for the individual and potentially family members. Genetic counseling recommended.
No pathogenic variant detected
No known ALS-associated mutations found, but does not exclude sporadic ALS or mutations in untested genes.
Variant of uncertain significance (VUS)
A genetic change whose impact on ALS risk is unclear. Further testing and family studies may be needed.
C9orf72 repeat expansion
A common genetic cause of familial ALS, associated with increased risk and potential for other neurodegenerative conditions.
Consult a neurologist or genetic specialist if you experience ALS symptoms, have a family history of ALS, or need guidance on test results for diagnosis and management.
Limitations
- ⚠Test may not detect all genetic variants due to technical limitations
- ⚠Results do not guarantee disease onset or progression
- ⚠Negative result does not completely rule out genetic predisposition
- ⚠Interpretation requires clinical correlation and genetic counseling
Risks & Considerations
- ●Minor bruising or pain at the blood draw site
- ●Rare risk of infection or fainting
Interfering Factors
- ●Contaminated or insufficient blood sample
- ●Recent blood transfusion (may affect DNA quality)
- ●Use of certain medications that could impact sample stability
- ●Improper storage or handling of the sample
Frequently Asked Questions
What is the cost of the ALS genetic test at DNA Labs India?
Is home sample collection available?
How long does it take to get results?
What sample is required for the test?
Do I need to fast before the test?
Can this test diagnose ALS definitively?
What genes are tested in this panel?
Is the test suitable for children?
How accurate is the genetic test for ALS?
What if a variant of uncertain significance is found?
Does a negative result mean I won't get ALS?
How do I book the test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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