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Nx Gen Sequencing: Familial Hemiplegic Migraine Test

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Nx Gen Sequencing: Familial Hemiplegic Migraine Test

Short Name: Familial Hemiplegic Migraine Test

Also known as: FHM Genetic Test, Familial Hemiplegic Migraine Sequencing

Nx Gen Sequencing: Familial Hemiplegic Migraine Test test available at DNA Labs India for ₹23,400. Uses Next-Generation Sequencing (NGS), Sanger Sequencing on Whole Blood samples. Results in Report delivery within 40 working days from sample receipt.. Free home collection in 300+ cities across India.

Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the Nx Gen Sequencing test for Familial Hemiplegic Migraine is to identify genetic mutations in the ATP1A2, CACNA1A, PRRT2, and SCN1A genes, which are associated with FHM. This test helps confirm a clinical diagnosis, differentiate FHM from other migraine types or neurological conditions, assess genetic risk in families, guide personalized treatment strategies, and facilitate genetic counseling for affected individuals and their relatives.

Test Code
1323
Price
₹23,400
Sample Type
Whole Blood
Result Time
Report delivery within 40 working days from sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS), Sanger Sequencing
Step 1

Sample Collection

Ensure the patient has signed the mandatory Whole Exome Sequencing Consent Form (Form 37). No fasting is required. Inform the patient about the test procedure and sample collection.

Method: Venipuncture

Step 2

Laboratory Analysis

Collect 10 mL of whole blood via venipuncture from two Lavender Top (EDTA) tubes, with a minimum of 5 mL per tube. Label tubes correctly and mix gently to prevent clotting.

Step 3

Report Delivery

Ship the sample refrigerated (2-8°C) immediately. Do not freeze. Complete all documentation and ensure the sample is sent to the laboratory within stability limits.

Timeline: Report delivery within 40 working days from sample receipt.

Patient Instructions

1
Before the Test:Prior to testing, genetic counseling is recommended to discuss implications, benefits, and limitations. The patient must provide informed consent using Form 37.
2
During the Test:The test involves blood sample collection, DNA extraction, and sequencing using NGS and Sanger methods to detect mutations in specified genes.
3
After the Test:Results are reported online or via email/WhatsApp. Follow-up with a healthcare provider is essential for result interpretation and management planning.

About This Test

Who Should Get This Test

The purpose of the Nx Gen Sequencing test for Familial Hemiplegic Migraine is to identify genetic mutations in the ATP1A2, CACNA1A, PRRT2, and SCN1A genes, which are associated with FHM. This test helps confirm a clinical diagnosis, differentiate FHM from other migraine types or neurological conditions, assess genetic risk in families, guide personalized treatment strategies, and facilitate genetic counseling for affected individuals and their relatives.

How to Prepare

  • Submit 10 mL (5 mL min.) whole blood from 2 Lavender Top (EDTA) tubes.
  • Ship refrigerated. DO NOT FREEZE.
  • Duly filled Whole Exome Sequencing Consent Form (Form 37) is mandatory.
  • Ensure sample integrity by avoiding hemolysis or contamination.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for Familial Hemiplegic Migraine (FHM) is crucial for confirming diagnosis and enabling personalized treatment, reducing diagnostic uncertainty and improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole Blood
Sample Volume10 mL (5 mL min.)
ContainerLavender Top (EDTA) tubes
Collection MethodVenipuncture

Sample Stability

Room Temperature
Refrigerator (2-8°C)
Frozen
Sample Rejection Criteria:
  • Sample received frozen when specified not to freeze.
  • Insufficient volume (less than 5 mL).
  • Use of non-EDTA tubes or incorrect anticoagulant.
  • Hemolyzed or clotted sample.
  • Missing or incomplete consent form (Form 37).

Understanding Your Results

Results from the Nx Gen Sequencing test for Familial Hemiplegic Migraine are interpreted based on the detection of pathogenic or likely pathogenic variants in the ATP1A2, CACNA1A, PRRT2, and SCN1A genes. A positive result indicates a genetic diagnosis of FHM, while a negative result means no mutations were found in these specific genes, but does not entirely rule out FHM due to other genetic or non-genetic factors.
📊

Positive (Pathogenic Variant Detected)

Confirms genetic diagnosis of FHM; recommend clinical correlation, genetic counseling, and personalized treatment planning.

📊

Negative (No Pathogenic Variants)

No mutations found in tested genes; consider other causes of symptoms and further diagnostic evaluation if clinically indicated.

📊

Variant of Uncertain Significance (VUS)

Genetic variant identified but clinical significance is unknown; recommend follow-up testing, family studies, or re-evaluation as more data becomes available.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience severe headaches with unilateral paralysis, have a family history of FHM, or if test results are positive or unclear. Immediate medical attention is needed for sudden neurological symptoms or worsening conditions.

Limitations

  • ⚠This test only screens for mutations in the ATP1A2, CACNA1A, PRRT2, and SCN1A genes; other genetic causes of FHM may not be detected.
  • ⚠Results may include variants of uncertain significance (VUS) requiring further investigation.
  • ⚠Test does not rule out non-genetic causes of migraine or neurological symptoms.
  • ⚠Turnaround time of 40 working days may delay diagnosis in urgent cases.

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising, infection, or discomfort.
  • ●Potential psychological impact of genetic results, necessitating counseling.
  • ●Risk of inconclusive results requiring additional testing.

Interfering Factors

  • ●Hemolyzed blood sample
  • ●Improper sample storage (e.g., freezing when not allowed)
  • ●Contamination during collection or transport
  • ●Insufficient sample volume (less than 5 mL)
  • ●Use of incorrect anticoagulant tubes (not EDTA)

Compare With Similar Tests

TestNx Gen Sequencing: Familial Hemiplegic Migraine TestMigraine Genetic PanelCACNA1A Gene TestWhole Exome SequencingNeurological Disorder Screening
ComparisonNx Gen Sequencing: Familial Hemiplegic Migraine Test

Frequently Asked Questions

What is Familial Hemiplegic Migraine (FHM)?
FHM is a rare genetic form of migraine characterized by severe headaches, temporary paralysis on one side of the body, and other neurological symptoms like nausea and visual disturbances.
How is the Nx Gen Sequencing test performed?
The test involves collecting a blood sample, extracting DNA, and using NGS and Sanger sequencing to detect mutations in genes associated with FHM.
What genes are tested in this panel?
The test analyzes the ATP1A2, CACNA1A, PRRT2, and SCN1A genes for mutations linked to FHM.
What is the cost of the test?
The test costs INR 23400.0, with free home sample collection available across India for online bookings.
How long does it take to get results?
Results are typically available within 40 working days from sample receipt.
Is fasting required before the test?
No, fasting is not required. However, a filled consent form (Form 37) is mandatory.
What does a positive test result mean?
A positive result indicates a genetic diagnosis of FHM, confirming mutations in the tested genes, which can guide treatment and genetic counseling.
Can this test be used for children or pregnant women?
Yes, it can be performed on individuals of all ages, but genetic counseling is recommended to discuss implications, especially in pediatric or prenatal cases.
What are the limitations of the test?
The test only screens specific genes and may not detect all genetic causes of FHM. Variants of uncertain significance may require further evaluation.
How should I prepare for sample collection?
Ensure the consent form is filled, avoid freezing the sample, and ship it refrigerated as soon as possible after collection.
Is the test covered by insurance in India?
Coverage varies by insurance provider and scheme. Check with your insurer or DNA Labs India for details.
What should I do if I get a negative result but still have symptoms?
Consult a neurologist for further evaluation, as symptoms may be due to other causes not covered by this test.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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