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PDCD10 Gene Cerebral cavernous malformations type 3 NGS Genetic Test

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PDCD10 Gene Cerebral cavernous malformations type 3 NGS Genetic Test

Short Name: PDCD10 Gene CCM Type 3 NGS Test

Also known as: CCM3 Genetic Test, PDCD10 Mutation Analysis

PDCD10 Gene Cerebral cavernous malformations type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the PDCD10 gene associated with cerebral cavernous malformations type 3, aiding in diagnosis, genetic counseling, and management of the condition.

Test Code
5319
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Genetic counseling is recommended prior to testing. Provide detailed clinical and family history.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture by a trained phlebotomist.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Store sample as instructed.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling to discuss implications, benefits, and limitations of testing.
2
During the Test:Blood sample collection procedure, typically taking a few minutes.
3
After the Test:Wait for report delivery in 3-4 weeks, then follow up with healthcare provider for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the PDCD10 gene associated with cerebral cavernous malformations type 3, aiding in diagnosis, genetic counseling, and management of the condition.

How to Prepare

  • Ensure patient identification is correct
  • Use sterile equipment
  • Label sample properly with patient details
  • Transport sample at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for PDCD10 gene mutations is essential for early diagnosis and management of cerebral cavernous malformations type 3, especially in families with a history of vascular diseases."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Blood sample
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Incorrect sample type or container
  • Missing patient information

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the PDCD10 gene. Positive results confirm genetic predisposition to CCM type 3, while negative results may require further clinical evaluation.
Positive result: Mutation detected, consistent with CCM type 3 diagnosis
Negative result: No pathogenic variants found, but clinical correlation is needed
Variant of uncertain significance (VUS): Further testing or family studies may be recommended
Consult a geneticist for comprehensive interpretation and counseling
⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms like seizures, headaches, or neurological deficits, or if you have a family history of cerebral cavernous malformations.

Limitations

  • ⚠May not detect all types of mutations, such as large deletions or duplications
  • ⚠Results may include variants of uncertain significance (VUS)
  • ⚠Does not rule out other genetic or non-genetic causes of symptoms

Risks & Considerations

  • ●Minor bruising or pain at the blood draw site
  • ●Rare risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Improper sample storage or handling
  • ●Recent blood transfusion

Compare With Similar Tests

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ComparisonPDCD10 Gene Cerebral cavernous malformations type 3 NGS Genetic Test

Frequently Asked Questions

What is the PDCD10 Gene Cerebral Cavernous Malformations Type 3 NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the PDCD10 gene, which causes cerebral cavernous malformations type 3.
What are the symptoms of CCM type 3?
Symptoms include seizures, headaches, difficulty speaking, weakness or numbness, vision problems, and balance issues.
How is CCM type 3 diagnosed?
Diagnosis involves medical history, physical exam, imaging tests like MRI or CT, and genetic testing such as this NGS test.
What is the cost of this genetic test in India?
The test costs INR 20,000 at DNA Labs India, with home sample collection available.
Is fasting required for this test?
No, fasting is not required for this genetic test.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card.
How long does it take to get results?
Results are typically available in 3 to 4 weeks.
Is home sample collection available?
Yes, free home sample collection is offered for online bookings across India.
What does a positive result mean?
A positive result indicates a mutation in the PDCD10 gene, confirming genetic predisposition to CCM type 3.
Can this test be used for family planning?
Yes, genetic testing can inform family planning decisions through genetic counseling.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, but genetic results may have psychological implications.
What should I do if I have symptoms?
Seek medical attention immediately and consult a healthcare provider about genetic testing if recommended.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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