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PDYN Gene Spinocerebellar ataxia type 23, autosomal dominant NGS Genetic Test

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PDYN Gene Spinocerebellar ataxia type 23, autosomal dominant NGS Genetic Test

Short Name: SCA23 NGS Genetic Test

Also known as: SCA23 Genetic Test, PDYN Gene Sequencing, Spinocerebellar Ataxia Type 23 DNA Test

PDYN Gene Spinocerebellar ataxia type 23, autosomal dominant NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestUnisexAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect pathogenic mutations in the PDYN gene for definitive diagnosis of Spinocerebellar Ataxia Type 23, aiding in clinical management, genetic counseling, and family risk assessment.

Test Code
1843
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history review and genetic counselling session recommended to draw a pedigree chart of affected family members.

Method: Venipuncture or FTA card blood drop

Step 2

Laboratory Analysis

Standard blood draw from a vein or application of one drop of blood on an FTA card.

Step 3

Report Delivery

Sample labeled and transported to the laboratory under ambient room temperature for NGS processing.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss implications, family history, and obtain informed consent.
2
During the Test:Blood sample collection via venipuncture or FTA card method.
3
After the Test:Sample undergoes NGS analysis; report delivered in 3 to 4 weeks.

About This Test

Who Should Get This Test

To detect pathogenic mutations in the PDYN gene for definitive diagnosis of Spinocerebellar Ataxia Type 23, aiding in clinical management, genetic counseling, and family risk assessment.

How to Prepare

  • Ensure proper patient identification
  • Use sterile equipment
  • Store samples at room temperature
  • Avoid hemolysis during blood draw

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for SCA23 aids in accurate diagnosis, family planning, and tailored management. Consultation with a geneticist is recommended for interpretation and counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood or equivalent DNA
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card blood drop

Sample Stability

Blood in EDTA tube: Stable for 7 days at room temperature
FTA card: Stable for years if stored properly
Sample Rejection Criteria:
  • Hemolyzed samples
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the PDYN gene associated with Spinocerebellar Ataxia Type 23.
📊

Pathogenic mutation detected; confirms diagnosis of SCA23. Genetic counseling recommended.

Result type: Positive

📊

No pathogenic mutation detected; does not rule out other causes of ataxia. Clinical correlation advised.

Result type: Negative

⚠️ When to Consult a Doctor:

Consult a neurologist or geneticist if experiencing symptoms of ataxia, have a family history of SCA23, or after receiving test results for interpretation and management planning.

Limitations

  • ⚠May not detect all mutation types (e.g., large deletions)
  • ⚠Results require clinical correlation
  • ⚠False negatives possible in rare cases

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Degraded DNA samples
  • ●Sample contamination
  • ●Low DNA yield

Compare With Similar Tests

TestPDYN Gene Spinocerebellar ataxia type 23, autosomal dominant NGS Genetic TestSCA1 NGS TestSCA3 NGS TestFriedreich's Ataxia TestComprehensive Ataxia Panel
ComparisonPDYN Gene Spinocerebellar ataxia type 23, autosomal dominant NGS Genetic Test

Frequently Asked Questions

What is Spinocerebellar Ataxia Type 23 (SCA23)?
SCA23 is a rare autosomal dominant genetic disorder caused by mutations in the PDYN gene, leading to progressive cerebellar ataxia and neurological symptoms.
How is SCA23 inherited?
SCA23 is autosomal dominant, meaning a single copy of the mutated PDYN gene from either parent can cause the disorder.
What are the common symptoms of SCA23?
Symptoms include balance difficulties, unsteady gait, tremors, slurred speech, swallowing problems, vision issues, muscle weakness, and depression/anxiety.
How is SCA23 diagnosed?
Diagnosis is confirmed through genetic testing, specifically NGS DNA analysis of the PDYN gene, often accompanied by neurological evaluations.
What is the cost of the PDYN gene NGS test at DNA Labs India?
The test costs INR 20000, with free home sample collection available across India.
Is genetic testing covered by insurance?
Insurance coverage varies; it's advisable to check with your provider. DNA Labs India offers affordable pricing regardless.
What sample is required for the test?
A blood sample or extracted DNA, or one drop of blood on an FTA card, can be used.
How long does it take to get results?
Reports are delivered in 3 to 4 weeks via online portal, email, or WhatsApp.
Do I need fasting before the test?
No fasting is required; you can eat and drink normally before sample collection.
What should I do before getting tested?
A clinical history review and genetic counseling session are recommended to draw a family pedigree and understand implications.
Can this test be done at home?
Yes, DNA Labs India offers free home sample collection for this test in many cities across India.
What if the test result is positive?
A positive result confirms SCA23; consult a geneticist or neurologist for counseling, management options, and family planning.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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