Plasminogen Activator Inhibitor-1/SERPINE-1 4G/5G Genotyping Test
Short Name: SERPINE-1 4G/5G Genotyping
Also known as: PAI-1/SERPINE-1 4G/5G Genotyping
Plasminogen Activator Inhibitor-1/SERPINE-1 4G/5G Genotyping Test test available at DNA Labs India for ₹18,000. Uses PCR on Blood samples. Results in Reports are delivered in 9 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
Screens for genetic susceptibility for venous thromboembolism (VTE) or myocardial infarction (MI) in individuals with a personal or family history of thrombotic events and aids risk/benefit assessment for preventive or therapeutic interventions for VTE or MI.
- Test Code
- 3561
- Price
- ₹18,000
- Sample Type
- Blood
- Result Time
- Reports are delivered in 9 days after sample receipt.
- Fasting Required
- No
- Method
- PCR
Sample Collection
No fasting required. A duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Method: Venipuncture
Laboratory Analysis
A single 4 mL blood sample is collected from a vein in the arm.
Report Delivery
You can resume normal activities immediately. The sample should be kept refrigerated if not transported immediately.
Timeline: Reports are delivered in 9 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
Screens for genetic susceptibility for venous thromboembolism (VTE) or myocardial infarction (MI) in individuals with a personal or family history of thrombotic events and aids risk/benefit assessment for preventive or therapeutic interventions for VTE or MI.
How to Prepare
- No special dietary preparation is required.
- Do not freeze the whole blood sample.
- Ship refrigerated at 2-8°C.
- Submit duly filled Form 20 with the sample.
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This genetic test provides valuable information for patients with a history of unexplained thrombosis or recurrent pregnancy loss. It aids in risk stratification and guides preventive management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Frozen sample
- Insufficient volume (<2 mL)
- Missing or incomplete requisition form
Understanding Your Results
4G/4G
Homozygous for 4G allele. Associated with higher PAI-1 levels and increased risk of venous thromboembolism and myocardial infarction.
4G/5G
Heterozygous. Intermediate PAI-1 levels. Modest or uncertain increase in thrombotic risk depending on other factors.
5G/5G
Homozygous for 5G allele. Associated with lower PAI-1 levels and generally typical thrombotic risk.
If you have a personal or family history of blood clots, myocardial infarction at a young age, or recurrent miscarriages, consult your hematologist or cardiologist to discuss whether this test is appropriate.
Limitations
- ⚠This test only detects the SERPINE1 4G/5G variant and does not rule out other genetic or acquired causes of thrombosis.
Risks & Considerations
- ●Minimal risks: slight pain, bruising, or bleeding at the needle site.
Interfering Factors
- ●No food or drug interference expected for DNA-based genotyping.
- ●Recent allogeneic bone marrow transplantation may confound results.
Compare With Similar Tests
| Test | Plasminogen Activator Inhibitor-1/SERPINE-1 4G/5G Genotyping Test | ||||
|---|---|---|---|---|---|
| Comparison | Plasminogen Activator Inhibitor-1/SERPINE-1 4G/5G Genotyping Test | Detects a common polymorphism affecting PAI-1 levels and thrombotic risk. Useful for VTE/MI risk assessment. | Identifies resistance to activated protein C; strongly associated with VTE. Complements SERPINE-1 testing. | Detects a genetic variant increasing prothrombin levels and VTE risk. | Functional assays for natural anticoagulant deficiencies; used when inherited thrombophilia is suspected. |
Frequently Asked Questions
What is the SERPINE-1 4G/5G genotyping test?
Who should take this test?
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Can this test diagnose a blood clot?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
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