Pre-Eclampsia Predictor (sFLT-1 Test
Short Name: sFLT-1:PIGF Ratio Test
Also known as: sFlt-1/PlGF Ratio Test, Pre-eclampsia Screening Test, Soluble fms-Like Tyrosine Kinase-1 to Placental Growth Factor Ratio, Preeclampsia Predictor Panel
Pre-Eclampsia Predictor (sFLT-1 Test test available at DNA Labs India for ₹4,500. Uses ECLIA (Electrochemiluminescence Immunoassay) on Serum samples. Results in Same-day reporting available when the sample is received on Tuesday, Thursday, or Saturday by 9 am.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The purpose of the sFLT-1:PIGF ratio panel test is to assist in the early prediction and risk stratification of pre-eclampsia in pregnant women from 20 weeks gestation onwards. By measuring the ratio of sFLT-1 to PlGF in maternal serum, the test helps clinicians identify women at high risk of developing pre-eclampsia or those with suspected pre-eclampsia. A low ratio provides reassurance and may reduce unnecessary hospital admissions, while a high ratio signals the need for closer surveillance, additional investigations, and possible intervention. This test is designed to complement, not replace, standard clinical assessment.
- Test Code
- 1389
- ICD Code
- O14.9
- Price
- ₹4,500
- Sample Type
- Serum
- Result Time
- Same-day reporting available when the sample is received on Tuesday, Thursday, or Saturday by 9 am.
- Fasting Required
- No
- Method
- ECLIA (Electrochemiluminescence Immunoassay)
Sample Collection
No special preparation, fasting, or dietary restrictions are required before this test. Inform your healthcare provider about any current medications or pre-existing medical conditions. Continue all prescribed medications unless advised otherwise by your doctor.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 mL of blood from a vein in your arm (venipuncture) using standard aseptic technique. The procedure typically takes only a few minutes and may involve minimal discomfort at the puncture site.
Report Delivery
After blood collection, slight bruising or soreness at the puncture site may occur, which typically resolves within a day. Apply gentle pressure with cotton if needed. You can resume normal activities immediately after sample collection.
Timeline: Same-day reporting available when the sample is received on Tuesday, Thursday, or Saturday by 9 am.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the sFLT-1:PIGF ratio panel test is to assist in the early prediction and risk stratification of pre-eclampsia in pregnant women from 20 weeks gestation onwards. By measuring the ratio of sFLT-1 to PlGF in maternal serum, the test helps clinicians identify women at high risk of developing pre-eclampsia or those with suspected pre-eclampsia. A low ratio provides reassurance and may reduce unnecessary hospital admissions, while a high ratio signals the need for closer surveillance, additional investigations, and possible intervention. This test is designed to complement, not replace, standard clinical assessment.
How to Prepare
- No fasting is required before sample collection
- Stay hydrated and drink adequate water before the test
- Wear loose-fitting clothing that allows easy access to the arm
- Inform the phlebotomist if you have a history of fainting during blood draws
- Bring your doctor's prescription or referral form
- Sample should be collected on Tuesday, Thursday, or Saturday by 9 am for same-day reporting
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The sFLT-1/PlGF ratio is a valuable adjunctive tool in the assessment of suspected pre-eclampsia. When used alongside standard clinical evaluation including blood pressure monitoring and urine protein assessment, it can significantly improve diagnostic confidence. A ratio below 38 at or after 20 weeks gestation has a high negative predictive value, helping to rule out pre-eclampsia within the subsequent week. This can reduce unnecessary hospital admissions and interventions. However, a high ratio warrants close clinical monitoring and timely intervention. This test should always be interpreted in the context of the complete clinical picture by a qualified obstetrician."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Haemolysed samples
- Lipaemic samples
- Samples received beyond stability period
- Insufficient sample volume (less than 1 mL)
- Improperly labelled or unlabelled samples
- Samples collected in incorrect tube type
Understanding Your Results
A ratio below 38 indicates a low probability of developing pre-eclampsia within the next week (negative predictive value approximately 99%). This result supports the clinical decision to avoid unnecessary hospitalisation. Continued routine antenatal monitoring is advised.
Range: sFLT-1/PlGF Ratio < 38
An intermediate ratio warrants cautious clinical evaluation. While not definitively high risk, closer monitoring of blood pressure, urine protein, and symptoms is recommended. Repeat testing may be considered within 2-3 weeks.
Range: sFLT-1/PlGF Ratio 38-85
A ratio above 85 is associated with a significantly increased risk of pre-eclampsia. Immediate clinical assessment, closer monitoring, and potential hospitalisation may be required. The treating obstetrician will determine the appropriate management plan, which may include antihypertensive therapy, corticosteroids for fetal lung maturity, or planned early delivery depending on gestational age and severity.
Range: sFLT-1/PlGF Ratio > 85
Consult your obstetrician or gynaecologist immediately if you experience any of the following symptoms during pregnancy: persistent high blood pressure readings, sudden swelling of the hands and face, severe headaches that do not resolve with usual measures, visual disturbances such as blurred vision or seeing spots, pain in the upper right abdomen, sudden weight gain, or a significant decrease in fetal movements. Early consultation is critical for timely diagnosis and management of pre-eclampsia.
Limitations
- ⚠This test is intended as a risk assessment tool and does not independently diagnose pre-eclampsia
- ⚠Must be used in conjunction with clinical judgement, blood pressure measurement, and other investigations
- ⚠The test is validated for use from 20 weeks gestation until delivery; results before 20 weeks may not be reliable
- ⚠Cut-off values may vary slightly between assays and laboratories
- ⚠False positives and false negatives can occur; clinical context must always be considered
- ⚠Not a replacement for regular antenatal check-ups and monitoring
Risks & Considerations
- ●Minimal: slight bruising or discomfort at the venipuncture site
- ●Rare: mild dizziness or lightheadedness during blood draw
- ●Very rare: infection at the puncture site (standard aseptic precautions are followed)
Interfering Factors
- ●Severe maternal renal impairment may affect protein levels
- ●Multiple gestation (twins or higher-order pregnancies) may alter baseline biomarker levels
- ●Conditions affecting placental function such as intrauterine growth restriction (IUGR)
- ●Pre-existing chronic hypertension or autoimmune conditions
- ●Haemolysed or lipaemic samples may affect assay accuracy
- ●Extremely early gestational age (before 20 weeks) may yield unreliable results
Compare With Similar Tests
| Test | Pre-Eclampsia Predictor (sFLT-1 | |||
|---|---|---|---|---|
| Comparison | Pre-Eclampsia Predictor (sFLT-1 |
Frequently Asked Questions
What is the sFLT-1:PIGF ratio panel test?
Who should take the pre-eclampsia predictor test?
At what stage of pregnancy should this test be done?
How is the test performed and does it require fasting?
What does a low sFLT-1/PlGF ratio mean?
What does a high sFLT-1/PlGF ratio mean?
Can this test alone diagnose pre-eclampsia?
Is the sFLT-1:PIGF ratio test safe for the mother and baby?
What is the cost of the pre-eclampsia predictor test at DNA Labs India?
When will I receive my test results?
How accurate is the sFLT-1:PIGF ratio test for predicting pre-eclampsia?
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