PRNP Gene Huntington disease-like type 1 NGS Genetic Test
Short Name: PRNP HDL1 NGS Test
Also known as: PRNP Gene Mutation Test, Prion Protein Gene NGS Test, Huntington Disease-Like Type 1 Genetic Test
PRNP Gene Huntington disease-like type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are issued within 3 to 4 weeks from the date the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS genetic test is to detect pathogenic variants in the PRNP gene to confirm a diagnosis of Huntington disease-like type 1, guide genetic counseling, and support family planning decisions.
- Test Code
- 4135
- CPT Code
- N/A
- ICD Code
- N/A
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are issued within 3 to 4 weeks from the date the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. Pre-test genetic counseling is recommended to review clinical history, document symptoms, and draw a family pedigree. Please carry a valid government ID and doctor's prescription if available.
Method: Venous blood draw / FTA blood spot
Laboratory Analysis
A standard blood sample is collected by a trained phlebotomist. For FTA card samples, a few drops of blood are applied to the filter paper card.
Report Delivery
You can resume normal activities immediately. The sample will be securely transported to the laboratory for NGS analysis.
Timeline: Reports are issued within 3 to 4 weeks from the date the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS genetic test is to detect pathogenic variants in the PRNP gene to confirm a diagnosis of Huntington disease-like type 1, guide genetic counseling, and support family planning decisions.
How to Prepare
- No special preparation is needed for this test.
- Carry any previous medical records, imaging reports, or genetic testing reports if available.
- Inform the laboratory about the patient's clinical symptoms and family history.
- For blood collection, an EDTA tube is commonly used; confirm with the laboratory for the exact sample requirement.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"A detailed neurological evaluation and genetic counseling are essential when assessing patients with suspected PRNP-related disorders. The test result must be interpreted alongside clinical findings, family history, and relevant neurological investigations."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Heavily hemolyzed or clotted blood sample
- Inadequate DNA quantity or quality
- Sample with incorrect or missing patient identification
- Sample received in expired or wrong collection tube
Understanding Your Results
Positive / Pathogenic variant
A disease-causing variant was identified in the PRNP gene, confirming the genetic diagnosis in an appropriate clinical context.
Negative / No pathogenic variant
No known disease-causing variant was detected. This does not completely exclude a genetic cause; clinical correlation is required.
Variant of uncertain significance (VUS)
A variant was found whose effect on protein function is unknown. Additional family studies or functional studies may be needed.
Likely benign / Benign variant
The variant is not believed to be associated with disease.
Consult a neurologist or medical geneticist if you or a family member have symptoms such as unexplained muscle stiffness, tremors, balance problems, cognitive decline, or behavioral changes. A doctor will help decide if genetic testing is appropriate and can explain the implications of the results.
Limitations
- ⚠NGS may not detect large deletions, insertions, repeat expansions, or methylation abnormalities.
- ⚠A negative result does not rule out genetic prion disease caused by other genes or non-genetic causes.
- ⚠Variant classification may change over time as new scientific evidence emerges.
- ⚠The test cannot predict age of onset or disease severity.
Risks & Considerations
- ●Blood draw may cause minor pain, bruising, or light-headedness.
- ●Genetic results may have psychological and emotional implications.
- ●Incidental or uncertain findings may require additional counseling and follow-up.
Interfering Factors
- ●Insufficient or degraded DNA
- ●Sample contamination
- ●Incorrect sample labeling
- ●Presence of genetic variants outside the analyzed region
- ●Lack of detailed clinical information for variant interpretation
Compare With Similar Tests
| Test | PRNP Gene Huntington disease-like type 1 NGS Genetic Test | ||
|---|---|---|---|
| Comparison | PRNP Gene Huntington disease-like type 1 NGS Genetic Test |
Frequently Asked Questions
What is the cost of the PRNP gene Huntington disease-like type 1 NGS genetic test?
What is PRNP gene Huntington disease-like type 1?
What sample is needed for this test?
Do I need to fast before the test?
How long will the reports take?
Why is NGS used for this genetic test?
Will I receive raw data files with the report?
Is home sample collection available?
Who should consider this PRNP NGS test?
Is genetic counseling required before testing?
What does a positive or negative result mean?
Is the test covered by health insurance?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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