PTHrP Parathyroid Hormone Related Protein Test
Short Name: Anti-Tr (DNER) Test
Also known as: Anti-Tr antibody test, Purkinje Cell Cytoplasmic Antibody Type Tr, DNER Antibody Test
PTHrP Parathyroid Hormone Related Protein Test test available at DNA Labs India for ₹21,000. Uses CBA-IFA (Cell Binding Assay - Indirect Immunofluorescence) on Blood (Serum) or CSF samples. Results in Samples are accepted until the 7th of each month. Reports are typically issued within 2 to 3 weeks from sample receipt.. Free home collection in 300+ cities across India.
Overview
The primary purpose of the Purkinje Cell Cytoplasmic Antibody Type Tr (DNER) test is to identify the presence of anti-Tr antibodies in serum or CSF. These autoantibodies target the DNER protein on Purkinje cells and are a well-recognized biomarker for paraneoplastic cerebellar degeneration and autoimmune cerebellar ataxia. Detection of these antibodies supports the clinical diagnosis, aids in early cancer surveillance, and helps differentiate autoimmune causes from other neurological conditions.
- Test Code
- 3583
- Price
- ₹21,000
- Sample Type
- Blood (Serum) or CSF
- Result Time
- Samples are accepted until the 7th of each month. Reports are typically issued within 2 to 3 weeks from sample receipt.
- Fasting Required
- Yes (8 hours)
- Method
- CBA-IFA (Cell Binding Assay - Indirect Immunofluorescence)
Sample Collection
Overnight fasting is preferred. Please inform your doctor about all medications you are currently taking, especially immunosuppressants. The Test Send Out Consent Form (Form 35) must be duly filled before sample collection.
Method: Venipuncture or Lumbar Puncture
Laboratory Analysis
A trained phlebotomist will collect a blood sample from a vein in your arm. If CSF analysis is required, a lumbar puncture will be performed by a qualified healthcare professional.
Report Delivery
No specific post-test precautions are required. You may resume normal activities immediately. If a lumbar puncture was done, follow the physician's advice regarding rest and hydration.
Timeline: Samples are accepted until the 7th of each month. Reports are typically issued within 2 to 3 weeks from sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Purkinje Cell Cytoplasmic Antibody Type Tr (DNER) test is to identify the presence of anti-Tr antibodies in serum or CSF. These autoantibodies target the DNER protein on Purkinje cells and are a well-recognized biomarker for paraneoplastic cerebellar degeneration and autoimmune cerebellar ataxia. Detection of these antibodies supports the clinical diagnosis, aids in early cancer surveillance, and helps differentiate autoimmune causes from other neurological conditions.
How to Prepare
- Duly filled Test Send Out Consent Form (Form 35) is mandatory.
- Use a Red Top (No Additive) tube for serum; avoid SST gel barrier tubes.
- For CSF, collect in a sterile screw-capped container.
- Ship samples refrigerated or frozen as per transport guidelines.
Doctor's Notes
"Anti-Tr antibody testing is essential in the evaluation of subacute cerebellar ataxia, especially when a paraneoplastic etiology is suspected. Early detection can significantly guide cancer screening and immunotherapy decisions."
Test Parameters & Specifications
Sample Stability
- Use of SST gel barrier tubes for serum collection
- Hemolyzed or lipemic samples
- Improperly labeled samples
- CSF samples contaminated with blood
- Samples not accompanied by consent form
Understanding Your Results
Negative
No anti-Tr/DNER antibodies detected. Other autoimmune or neurological causes should be considered.
Positive
Anti-Tr/DNER antibodies present. Strongly supports paraneoplastic cerebellar degeneration or autoimmune cerebellar ataxia. Prompts screening for associated malignancies such as Hodgkin lymphoma, ovarian, uterine, or small cell lung carcinomas.
If you are experiencing progressive ataxia, difficulty speaking or swallowing, involuntary eye movements, tremors, dizziness, or cognitive decline, consult a neurologist immediately. Early diagnosis can help identify underlying cancer and initiate timely treatment.
Limitations
- ⚠A negative result does not completely rule out paraneoplastic cerebellar degeneration; other antibodies may be involved.
- ⚠Positive results must be interpreted in clinical context, as some patients may be asymptomatic.
- ⚠The test is not intended for routine screening in the absence of neurological symptoms.
- ⚠Cross-reactivity with other Purkinje cell antibodies may occur in rare cases.
Risks & Considerations
- ●Slight pain or bruising at the blood collection site
- ●Lightheadedness during blood draw
- ●For lumbar puncture: headache, back discomfort, or rare infection
- ●No other significant risks associated with the antibody test itself
Interfering Factors
- ●Recent immunosuppressive therapy may reduce antibody levels and lead to false-negative results.
- ●Hemolyzed or lipemic samples may interfere with immunofluorescence assays.
- ●Improper handling or delayed processing may affect antibody stability.
- ●Contamination of CSF with blood can cause non-specific staining.
Compare With Similar Tests
| Test | PTHrP Parathyroid Hormone Related Protein Test | ||||
|---|---|---|---|---|---|
| Comparison | PTHrP Parathyroid Hormone Related Protein Test |
Frequently Asked Questions
What is the Purkinje Cell Cytoplasmic Antibody Type Tr (DNER) test?
How is the test performed?
Do I need to fast for this test?
What does a positive result mean?
Which cancers are associated with anti-Tr antibodies?
How long does it take to get results?
What is the cost of the test?
Is home sample collection available?
Which specialist should order this test?
Can this test be performed on CSF?
What symptoms lead to this test?
Is the test covered by health insurance?
Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.