RAD51 Gene Mirror movements type 2 NGS Genetic Test
Short Name: RAD51 Mirror Movements Type 2 Test
Also known as: RAD51 Gene Sequencing Test, Congenital Mirror Movement Disorder Type 2 Genetic Test, RAD51 NGS Panel Test, CMMD2 Genetic Test, RAD51 Mutation Analysis Test
RAD51 Gene Mirror movements type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are available within 3 to 4 weeks from the date of sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The primary purpose of the RAD51 Gene Mirror Movements Type 2 NGS Genetic Test is to confirm the molecular diagnosis of Congenital Mirror Movement Disorder Type 2 by identifying pathogenic or likely pathogenic mutations in the RAD51 gene. This test aids clinicians in differentiating RAD51-related mirror movements from other genetic and non-genetic movement disorders, enables carrier status determination for at-risk family members, supports genetic counselling and family planning decisions, and contributes to a better understanding of the patient's prognosis and appropriate management strategies.
- Test Code
- 1725
- CPT Code
- 81479
- ICD Code
- G80.8
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are available within 3 to 4 weeks from the date of sample collection.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation such as fasting is required. A pre-test genetic counselling session is recommended to discuss the clinical history of the patient, draw a pedigree chart of family members affected with mirror movements, and obtain informed consent. Bring any previous medical records, neurological evaluation reports, and family history information.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect 3-5 mL of peripheral venous blood using standard venipuncture technique into an EDTA (Lavender Top) vacutainer. Alternatively, extracted DNA or one drop of blood on an FTA card may be submitted. The procedure typically takes 5-10 minutes and involves minimal discomfort.
Report Delivery
After sample collection, gentle pressure should be applied to the venipuncture site. The sample will be transported under appropriate conditions to the laboratory for processing. Results will be available within 3 to 4 weeks and delivered via the online portal, email, or WhatsApp. A post-test genetic counselling session is recommended to discuss results and implications.
Timeline: Results are available within 3 to 4 weeks from the date of sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the RAD51 Gene Mirror Movements Type 2 NGS Genetic Test is to confirm the molecular diagnosis of Congenital Mirror Movement Disorder Type 2 by identifying pathogenic or likely pathogenic mutations in the RAD51 gene. This test aids clinicians in differentiating RAD51-related mirror movements from other genetic and non-genetic movement disorders, enables carrier status determination for at-risk family members, supports genetic counselling and family planning decisions, and contributes to a better understanding of the patient's prognosis and appropriate management strategies.
How to Prepare
- Ensure the patient has not received a blood transfusion in the last 4 weeks
- Collect 3-5 mL of venous blood in an EDTA (Lavender Top) vacutainer
- Label the sample clearly with patient name, date of birth, and unique identifier
- Gently invert the tube 8-10 times to mix blood with EDTA anticoagulant
- Do not freeze the blood sample; store at room temperature (15-25°C) or 2-8°C
- Transport the sample to the laboratory within 48-72 hours of collection
- Alternatively, extracted DNA (minimum 50 ng/µL) or blood on FTA card is accepted
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"As a clinical geneticist, I recommend the RAD51 Gene Mirror Movements Type 2 NGS Genetic Test for patients presenting with congenital mirror movements, particularly when family history suggests autosomal recessive inheritance. Early molecular diagnosis enables precise genetic counselling, targeted carrier screening for at-risk family members, and informed reproductive decision-making. The NGS approach provides comprehensive coverage of the RAD51 gene coding regions and flanking intronic sequences, ensuring high diagnostic sensitivity for the detection of single nucleotide variants, small insertions and deletions. A confirmed diagnosis also helps differentiate RAD51-related mirror movements from other genetic and non-genetic causes of involuntary motor symptoms, guiding appropriate long-term neurological management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume (less than 2 mL)
- Improperly labeled or unlabeled samples
- Samples collected in incorrect anticoagulant tubes
- Samples older than 7 days without appropriate storage conditions
- Contaminated samples
Understanding Your Results
Pathogenic Variant Detected
A mutation known to cause Mirror Movements Type 2 was identified in the RAD51 gene. This confirms the molecular diagnosis of CMMD2. Genetic counselling is recommended for the patient and family members.
Likely Pathogenic Variant Detected
A variant was identified that is predicted to be disease-causing based on available evidence. Correlation with clinical findings and family studies is recommended. Genetic counselling is advised.
Variant of Uncertain Significance (VUS)
A variant was identified, but current evidence is insufficient to determine whether it is pathogenic or benign. Further testing, family segregation studies, and clinical correlation may be needed. This result should not be used for clinical decision-making without additional information.
Likely Benign Variant Detected
A variant was identified that is unlikely to be associated with Mirror Movements Type 2. Clinical correlation is recommended.
No Pathogenic Variant Detected
No known pathogenic or likely pathogenic variants were identified in the RAD51 gene. This result does not completely exclude a genetic cause for the patient's symptoms, as mutations in other genes may be responsible. Additional genetic testing may be considered.
You should consult a doctor if you or your child experiences involuntary mirrored movements of the limbs that are present from birth or early childhood, difficulty with fine motor tasks, muscle stiffness, impaired bimanual coordination, or any symptoms suggestive of a congenital mirror movement disorder. Additionally, consult a clinical geneticist if there is a known family history of mirror movements or if carrier status needs to be determined for family planning purposes.
Limitations
- ⚠This test does not detect mutations in other genes associated with mirror movement disorders (e.g., DCC gene for CMMD1)
- ⚠Large structural variants, copy number variations, and deep intronic mutations may not be reliably detected by standard NGS
- ⚠Variants of uncertain significance (VUS) may be identified and require further evaluation
- ⚠Results must be interpreted in the context of clinical presentation, family history, and additional diagnostic findings
- ⚠Mosaicism at low levels may not be detected
- ⚠The test does not rule out other genetic or acquired causes of involuntary movements
Risks & Considerations
- ●Minimal risk associated with blood collection, including minor bruising, swelling, or infection at the venipuncture site
- ●Psychological impact of receiving genetic test results, particularly if a pathogenic variant is identified
- ●Potential identification of variants of uncertain significance that may cause anxiety or require further testing
- ●Implications for family members who may need carrier or diagnostic testing based on the results
Interfering Factors
- ●Recent blood transfusion within the past 4 weeks may affect DNA quality
- ●Bone marrow or stem cell transplant may yield donor DNA instead of patient DNA
- ●Degraded or hemolyzed blood samples may reduce sequencing quality
- ●Sample contamination during collection or transport may impact results
Compare With Similar Tests
| Test | RAD51 Gene Mirror movements type 2 NGS Genetic Test | DCC Gene Mirror Movements Type 1 NGS Genetic Test | Neurological Gene Panel NGS Test | Whole Exome Sequencing (WES) Test | RAD51C Gene Sequencing Test |
|---|---|---|---|---|---|
| Comparison | RAD51 Gene Mirror movements type 2 NGS Genetic Test | Tests for mutations in the DCC gene associated with autosomal dominant congenital mirror movement disorder (CMMD1). Use this test when CMMD1 is clinically suspected rather than CMMD2. | A comprehensive panel testing multiple genes associated with neurological disorders including movement disorders. Broader in scope but may not provide the same depth of analysis for the RAD51 gene. | Analyzes all protein-coding genes in the genome. Useful when the specific genetic cause is unknown or when targeted gene testing is inconclusive. Higher cost and longer turnaround time. | Tests for mutations in the RAD51C gene, a paralog of RAD51, which is associated with cancer predisposition (breast and ovarian cancer) rather than mirror movement disorders. |
Frequently Asked Questions
What is the RAD51 Gene Mirror Movements Type 2 NGS Genetic Test?
Who should take this genetic test?
What is Mirror Movements Type 2 and what causes it?
How is the test performed and what sample is required?
What is the cost of the RAD51 Gene Mirror Movements Type 2 NGS Genetic Test?
Is home sample collection available for this test?
How long does it take to receive the test results?
What does a positive result mean?
Is Mirror Movements Type 2 an inherited condition?
Can this test be used for prenatal or preconception carrier screening?
Is genetic counselling recommended before and after this test?
What if no pathogenic variant is found but symptoms persist?
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