RAG2 Gene Combined immunodeficiency, B cell-negative, T cell-negative, NK cell positive NGS Genetic Test
Short Name: RAG2 CID NGS Test
Also known as: RAG2 Combined Immunodeficiency, B cell-negative, T cell-negative, NK cell positive immunodeficiency, RAG2 deficiency
RAG2 Gene Combined immunodeficiency, B cell-negative, T cell-negative, NK cell positive NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to diagnose RAG2 gene mutations that cause combined immunodeficiency, enabling accurate identification of the condition for appropriate medical management and family planning.
- Test Code
- 4863
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Clinical history of the patient and a genetic counseling session to draw a pedigree chart of affected family members are required before testing.
Method: Venipuncture or finger-prick
Laboratory Analysis
Standard blood draw procedure using venipuncture or finger-prick for FTA card.
Report Delivery
Sample is processed and shipped to the laboratory for analysis under controlled conditions.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to diagnose RAG2 gene mutations that cause combined immunodeficiency, enabling accurate identification of the condition for appropriate medical management and family planning.
How to Prepare
- Ensure proper labeling of samples
- Use sterile collection equipment
- Follow aseptic techniques
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for RAG2 mutations can guide treatment and family planning for immunodeficiency disorders."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient sample volume
- Improperly labeled samples
Understanding Your Results
Positive for pathogenic variants
Confirms diagnosis of RAG2 gene combined immunodeficiency; further clinical management recommended.
Negative for pathogenic variants
No mutations detected in the RAG2 gene; consider other genetic or immunological tests if symptoms persist.
Variant of uncertain significance
Genetic counseling and additional testing may be needed for clarification.
Consult a doctor if symptoms of immunodeficiency, such as recurrent infections or failure to thrive, are present, or for genetic counseling after test results.
Limitations
- ⚠May not detect all genetic variants
- ⚠Requires genetic counseling for interpretation
- ⚠Results may need confirmation with other tests
Risks & Considerations
- ●Minimal risks from blood draw, such as bruising or infection
- ●Rare allergic reactions to antiseptics
Interfering Factors
- ●Sample contamination
- ●Degraded DNA
- ●Improper sample storage
Compare With Similar Tests
| Test | RAG2 Gene Combined immunodeficiency, B cell-negative, T cell-negative, NK cell positive NGS Genetic Test | Whole Exome Sequencing | Sanger Sequencing | Immunoglobulin Level Test | Lymphocyte Subset Analysis |
|---|---|---|---|---|---|
| Comparison | RAG2 Gene Combined immunodeficiency, B cell-negative, T cell-negative, NK cell positive NGS Genetic Test | Broader genetic analysis but higher cost; NGS for RAG2 is targeted and cost-effective. | Traditional method for single-gene analysis; NGS offers higher throughput and sensitivity. | Measures antibody levels; genetic test identifies underlying genetic cause. | Assesses immune cell counts; genetic test confirms genetic etiology. |
Frequently Asked Questions
What is RAG2 Gene Combined Immunodeficiency?
What are the symptoms of this condition?
How is RAG2 Gene CID diagnosed?
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What sample is required for the test?
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How long does it take to get the results?
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What does a positive test result mean?
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