RELN Gene Epilepsy, familial temporal lobe type 7 NGS Genetic Test
Short Name: RELN Gene Epilepsy NGS Test
RELN Gene Epilepsy, familial temporal lobe type 7 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results will be available in 3 to 4 weeks after the sample is received at the laboratory. The report will be sent to your registered mobile/email and can also be downloaded from the DNA Labs India patient portal.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to confirm or rule out the presence of disease-causing mutations in the RELN gene, which are associated with familial temporal lobe epilepsy type 7. It aids in establishing a precise molecular diagnosis in individuals presenting with symptoms suggestive of temporal lobe epilepsy, especially when there is a family history. The test also helps in risk stratification and genetic counselling for at-risk relatives.
- Test Code
- 4071
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results will be available in 3 to 4 weeks after the sample is received at the laboratory. The report will be sent to your registered mobile/email and can also be downloaded from the DNA Labs India patient portal.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No special preparation like fasting is required. For genetic counselling, please bring relevant family history details and any prior diagnostic reports (EEG, MRI, or previous genetic tests).
Method: Venipuncture or fingerstick for FTA card
Laboratory Analysis
A standard blood draw will be performed. If using an FTA card, a small drop of blood will be placed on designated spots and allowed to dry. The procedure is quick and minimally invasive.
Report Delivery
No specific post-collection restrictions. You can resume normal activities immediately. The sample will be transported to the laboratory in an appropriate shipping container to ensure DNA stability.
Timeline: Results will be available in 3 to 4 weeks after the sample is received at the laboratory. The report will be sent to your registered mobile/email and can also be downloaded from the DNA Labs India patient portal.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to confirm or rule out the presence of disease-causing mutations in the RELN gene, which are associated with familial temporal lobe epilepsy type 7. It aids in establishing a precise molecular diagnosis in individuals presenting with symptoms suggestive of temporal lobe epilepsy, especially when there is a family history. The test also helps in risk stratification and genetic counselling for at-risk relatives.
How to Prepare
- Use lavender top EDTA tube for whole blood collection
- FTA card should have four to five dried blood spots
- Label the sample with patient name, date of birth, and collection date
- Ship sample at ambient temperature in a biohazard bag
- Avoid hemolyzed samples for DNA extraction
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for RELN gene helps confirm the clinical suspicion of familial temporal lobe epilepsy type 7 and enables informed genetic counselling for affected families."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or severely hemolyzed blood specimens
- Heparinised blood samples (heparin inhibits PCR)
- Insufficient sample volume
- Improperly stored or leaked samples
- FTA card with insufficient blood spots or contamination
Understanding Your Results
Positive (Pathogenic or Likely Pathogenic variant)
A disease-causing variant was identified in the RELN gene, confirming the molecular diagnosis of familial temporal lobe epilepsy type 7. Autosomal dominant inheritance is likely.
Action: Genetic counselling is recommended to discuss management, surveillance, and family testing.
Negative (No clinically relevant variant)
No pathogenic/likely pathogenic variant was detected in the RELN gene. This reduces the likelihood that RELN mutation is the cause of epilepsy.
Action: Consider further genetic or non-genetic evaluations if clinical suspicion remains high.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is currently unknown.
Action: Additional family testing or functional studies may be required to clarify significance.
You should consult your referring neurologist or clinical geneticist for interpretation of the genetic test result. The clinician will correlate the result with your clinical history, neurological examination, EEG, and MRI findings to guide appropriate management and family counselling.
Limitations
- ⚠This test is specific to the RELN gene and does not rule out other genetic or non-genetic causes of epilepsy
- ⚠Somatic and germline mosaicism may not be reliably detected
- ⚠Large structural rearrangements, trinucleotide repeat expansions, and mitochondrial genome variants are not evaluated in this targeted test
- ⚠Variants of uncertain significance may require further family studies or functional analysis
Risks & Considerations
- ●Minor bruising at the blood draw site
- ●Dizziness or lightheadedness during sample collection
- ●Rare possibility of infection at the puncture site (minimal with proper hygiene)
Interfering Factors
- ●Poor DNA quality or quantity may lead to suboptimal sequencing
- ●Extremely low-level mosaicism may not be detected by standard NGS
- ●Variants in deep intronic regions or large deletions/duplications may not be covered by this targeted gene test
Compare With Similar Tests
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| Comparison | RELN Gene Epilepsy, familial temporal lobe type 7 NGS Genetic Test |
Frequently Asked Questions
What is the RELN Gene Epilepsy NGS Genetic Test?
What does familial temporal lobe epilepsy type 7 mean?
How is the test performed?
Do I need to fast before the test?
What sample types are accepted?
How long will the results take?
What is the cost of the test?
Is home sample collection available?
What does a positive result mean?
Will this test identify all epilepsy mutations?
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