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RELN Gene Lissencephaly type 2 (Norman-Roberts type) NGS Genetic Test

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RELN Gene Lissencephaly type 2 (Norman-Roberts type) NGS Genetic Test

Short Name: RELN Lissencephaly Type 2 NGS Test

Also known as: Norman-Roberts syndrome, Lissencephaly type 2

RELN Gene Lissencephaly type 2 (Norman-Roberts type) NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the RELN Gene Lissencephaly type 2 NGS Genetic Test is to diagnose mutations in the RELN gene that cause Norman-Roberts syndrome, aiding in clinical management, genetic counseling, and family planning.

Test Code
2757
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next Generation Sequencing)
Step 1

Sample Collection

Genetic counseling is recommended prior to testing. Provide detailed clinical history and family pedigree information.

Method: Blood draw

Step 2

Laboratory Analysis

A blood sample is collected via venipuncture, or an alternative sample type such as extracted DNA or FTA card blood drop is used.

Step 3

Report Delivery

The sample is labeled, stored appropriately, and sent to the laboratory for NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule a consultation with a geneticist or referring specialist to discuss the test, provide clinical history, and understand implications.
2
During the Test:The test involves a simple blood draw or alternative sample collection, typically taking a few minutes.
3
After the Test:Wait for the report delivery in 3-4 weeks, then follow up with your doctor for result interpretation and next steps.

About This Test

Who Should Get This Test

The purpose of the RELN Gene Lissencephaly type 2 NGS Genetic Test is to diagnose mutations in the RELN gene that cause Norman-Roberts syndrome, aiding in clinical management, genetic counseling, and family planning.

How to Prepare

  • Ensure proper identification and documentation
  • Follow aseptic techniques during blood draw
  • Store samples at ambient temperature unless specified otherwise

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for lissencephaly is crucial for early diagnosis, informing treatment decisions, and assisting with family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodBlood draw

Sample Stability

Blood samples: Stable for 24-48 hours at room temperature
Extracted DNA: Stable for longer periods if stored properly
Sample Rejection Criteria:
  • Insufficient sample volume
  • Hemolyzed or contaminated samples
  • Improper labeling or documentation

Understanding Your Results

Results from the RELN Gene Lissencephaly type 2 NGS Genetic Test indicate the presence or absence of mutations in the RELN gene, which are causative for Norman-Roberts syndrome.
Positive Result: Pathogenic or likely pathogenic variant detected in the RELN gene, confirming diagnosis of lissencephaly type 2.
Negative Result: No pathogenic variants detected, but clinical correlation is advised as other genetic causes may exist.
Variant of Uncertain Significance (VUS): A genetic change with unknown clinical significance; further testing and family studies may be needed.
⚠️ When to Consult a Doctor:

Consult a doctor if symptoms of lissencephaly are present, such as seizures, developmental delays, or abnormal brain imaging findings, or for genetic counseling regarding family history.

Limitations

  • ⚠May not detect all types of genetic variants, such as large deletions or duplications
  • ⚠Results require interpretation by a genetic specialist
  • ⚠Cannot predict disease severity or progression accurately

Risks & Considerations

  • ●Minimal risks associated with blood draw, such as bruising or infection
  • ●Psychological impact of genetic results on patients and families

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA quality
  • ●Technical errors in sequencing

Frequently Asked Questions

What is the RELN Gene Lissencephaly type 2 NGS Genetic Test?
It is a genetic test that uses Next Generation Sequencing to detect mutations in the RELN gene, which cause lissencephaly type 2 (Norman-Roberts syndrome), a rare brain development disorder.
Who should consider this test?
Individuals with symptoms such as severe intellectual disability, seizures, developmental delays, or abnormal brain imaging suggestive of lissencephaly, and families with a history of the condition.
What are the symptoms of RELN gene lissencephaly type 2?
Symptoms include severe intellectual disability, developmental delays, seizures, abnormal muscle tone, poor feeding, difficulty breathing, and structural brain abnormalities.
How is the test performed?
The test involves collecting a blood sample, extracted DNA, or a blood drop on an FTA card, which is then analyzed using NGS technology to sequence the RELN gene.
What is the cost of the test?
The RELN Gene Lissencephaly type 2 NGS Genetic Test costs INR 20000 at DNA Labs India, with free home sample collection available in many cities.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is fasting required for this test?
No, fasting is not required for this genetic test.
What does a positive result mean?
A positive result indicates the presence of a pathogenic mutation in the RELN gene, confirming a diagnosis of lissencephaly type 2, which can guide treatment and genetic counseling.
Can this test be used for prenatal diagnosis?
Yes, genetic testing can be applied in prenatal settings if there is a known family history, but consultation with a genetic specialist is essential.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across numerous cities in India for online bookings.
What should I do before getting tested?
Before testing, consult with a geneticist or healthcare provider for genetic counseling, provide detailed clinical and family history, and understand the test implications.
Are there any risks associated with the test?
The test itself has minimal risks, such as those from a blood draw, but genetic results may have psychological impacts; genetic counseling is recommended to address these concerns.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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