RNF39 Gene Hippocampal longterm potentiation, RFN39 related NGS Genetic Test
Short Name: RNF39 NGS Test
Also known as: RNF39 LTP NGS Test, RNF39 gene mutation analysis, RNF39-related NGS genetic test
RNF39 Gene Hippocampal longterm potentiation, RFN39 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are usually generated within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify, in individuals with appropriate clinical symptoms or family history, pathogenic variants in RNF39 that may affect hippocampal long-term potentiation and contribute to neurological manifestations. NGS-based analysis helps clarify the genetic basis of the disorder and support clinical management, recurrence risk assessment and family screening.
- Test Code
- 4120
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are usually generated within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
A genetic counselling session is necessary to draw a pedigree chart and document affected family members. No fasting or special preparation is required.
Method: Peripheral venipuncture or dried blood spot FTA card collection
Laboratory Analysis
A peripheral blood sample is collected in an EDTA tube, or one drop of blood on an FTA card, or extracted DNA may be provided. The procedure takes just a few minutes.
Report Delivery
The sample is labelled and transported to the laboratory at the recommended temperature. You can resume routine activities immediately.
Timeline: Reports are usually generated within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify, in individuals with appropriate clinical symptoms or family history, pathogenic variants in RNF39 that may affect hippocampal long-term potentiation and contribute to neurological manifestations. NGS-based analysis helps clarify the genetic basis of the disorder and support clinical management, recurrence risk assessment and family screening.
How to Prepare
- No fasting required before sample collection
- Ensure correct patient identification and labelling
- Complete the consent and clinical history form before sample collection
- Genetic counselling session should ideally be completed before blood collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This genetic test should be used in combination with neurological and psychiatric assessment. RNF39 variants may be of uncertain significance, and a multidisciplinary approach is important for accurate interpretation."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or haemolysed blood sample
- Insufficient sample volume
- Highly degraded DNA
- Improperly labelled sample or missing consent
Understanding Your Results
Negative / No pathogenic variant detected
No clinically significant RNF39 variants were identified. If symptoms persist, other genetic, metabolic, or acquired causes should be considered.
Pathogenic / Likely pathogenic variant detected
A clinically significant variant is present. This supports a genetic contribution to the clinical presentation. Family screening and genetic counselling are recommended.
Variant of uncertain significance (VUS)
The detected variant has unknown clinical significance. Further segregation analysis, functional studies or reclassification may be needed.
Consult a neurologist or clinical geneticist if you or a family member experience progressive memory loss, unexplained cognitive decline, or psychiatric symptoms such as hallucinations and delusions, especially with a family history of neurological disorders.
Limitations
- ⚠NGS may not detect all structural, repeat-expansion or epigenetic variants.
- ⚠Variants of uncertain significance may be reported; additional family segregation or functional studies may be required.
- ⚠This test is not intended for prenatal diagnosis.
- ⚠Test results should not be used as a sole diagnostic tool and require interpretation by a qualified clinician or genetic counsellor.
Risks & Considerations
- ●Slight pain or bruising at the venepuncture site
- ●Very low risk of local infection
- ●No additional health risks from the genetic test itself
Interfering Factors
- ●Very low DNA yield or highly degraded DNA
- ●Sample contamination during collection
- ●Insufficient sequencing coverage in certain GC-rich regions
- ●Incorrect or incomplete clinical and family history
Compare With Similar Tests
| Test | RNF39 Gene Hippocampal longterm potentiation, RFN39 related NGS Genetic Test | Targeted Sanger Sequencing for RNF39 | Whole Exome Sequencing (WES) | Comprehensive Neurological Disorders NGS Panel |
|---|---|---|---|---|
| Comparison | RNF39 Gene Hippocampal longterm potentiation, RFN39 related NGS Genetic Test |
Frequently Asked Questions
What is the RNF39 gene?
What is long-term potentiation (LTP)?
Can mutations in RNF39 cause Alzheimer's disease or schizophrenia?
What type of genetic test is used?
What sample is required for the RNF39 NGS test?
Do I need to fast before the test?
How long will my reports take?
What does a positive RNF39 mutation result mean?
What does a negative RNF39 result mean?
Is home sample collection available?
What is the cost of the RNF39 gene NGS genetic test?
Should I have genetic counselling before or after this test?
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