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Immunohistochemistry ROS1 IHC Test

DNA Labs India | ISO 9001:2015 Certified

Immunohistochemistry ROS1 IHC Test

Short Name: ROS1 IHC Test

Also known as: ROS1 Rearrangement Test, ROS1 Immunohistochemistry Test

Immunohistochemistry ROS1 IHC Test test available at DNA Labs India for ₹6,000. Uses Immunohistochemistry on Tumor Tissue samples. Results in Report available in 5-7 days.. Free home collection in 300+ cities across India.

ImmunohistochemistryAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify ROS1 gene rearrangements in non-small cell lung cancer patients, guiding targeted therapy decisions.

Test Code
953
Price
₹6,000
Sample Type
Tumor Tissue
Result Time
Report available in 5-7 days.
Fasting Required
No
Method
Immunohistochemistry
Step 1

Sample Collection

Ensure histopathology report, biopsy site, and clinical history are available.

Method: Tissue Biopsy

Step 2

Laboratory Analysis

Standard tissue biopsy procedure performed by a healthcare professional.

Step 3

Report Delivery

Sample is processed and tested in the lab.

Timeline: Report available in 5-7 days.

Patient Instructions

1
Before the Test:Provide necessary documentation and sample as per instructions.
2
During the Test:Immunohistochemistry staining is performed on the tissue sample.
3
After the Test:Results are analyzed and reported by a pathologist.

About This Test

Who Should Get This Test

To identify ROS1 gene rearrangements in non-small cell lung cancer patients, guiding targeted therapy decisions.

How to Prepare

  • Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block
  • Ship at room temperature
  • Provide a copy of the Histopathology report, Site of biopsy and Clinical history

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early detection of ROS1 rearrangements is crucial for targeted therapy in lung cancer, improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeTumor Tissue
ContainerFormalin Container
Collection MethodTissue Biopsy

Sample Stability

Room TemperatureStable during shipping
Sample Rejection Criteria:
  • Inadequate tumor tissue
  • Improper fixation
  • Missing clinical information

Understanding Your Results

ROS1 IHC test results indicate the presence or absence of ROS1 gene rearrangements. Positive results suggest eligibility for targeted therapy.
📊

Positive

ROS1 rearrangement detected, consider targeted therapy with ROS1 inhibitors.

📊

Negative

No ROS1 rearrangement detected, other treatment options may be considered.

📊

Inconclusive

Test inconclusive, repeat testing or additional tests recommended.

⚠️ When to Consult a Doctor:

If experiencing symptoms of lung cancer such as persistent cough, chest pain, or shortness of breath, consult a doctor for evaluation and possible testing.

Limitations

  • ⚠Only detects ROS1 rearrangements, not other mutations
  • ⚠Requires sufficient tumor tissue
  • ⚠May not detect all variants

Risks & Considerations

  • ●Risks related to biopsy procedure, such as infection or bleeding

Interfering Factors

  • ●Poor tissue fixation
  • ●Inadequate sample size
  • ●Presence of necrotic tissue

Compare With Similar Tests

TestImmunohistochemistry ROS1 IHC TestFISH for ROS1PCR for ROS1
ComparisonImmunohistochemistry ROS1 IHC TestMore sensitive but costlier than IHC.Detects specific mutations, but requires different sample preparation.

Frequently Asked Questions

What is the ROS1 IHC test?
The ROS1 IHC test is an immunohistochemistry-based diagnostic test used to detect rearrangements in the ROS1 gene, often associated with non-small cell lung cancer.
What is the cost of the ROS1 IHC test at DNA Labs India?
The cost of the ROS1 IHC test at DNA Labs India is INR 6000, which includes home sample collection in many cities.
Who should undergo the ROS1 IHC test?
Patients diagnosed with non-small cell lung cancer, especially younger individuals with no smoking history and adenocarcinoma, may benefit from this test to guide targeted therapy.
How is the sample collected for the ROS1 IHC test?
The sample is collected via tissue biopsy, and tumor tissue is submitted in 10% formal-saline or formalin fixed paraffin embedded blocks.
What does a positive ROS1 IHC test result mean?
A positive result indicates the presence of ROS1 gene rearrangements, suggesting eligibility for targeted therapy with ROS1 inhibitors like Crizotinib.
What are the symptoms of non-small cell lung cancer?
Symptoms may include chest pain, coughing up blood, persistent cough, fatigue, shortness of breath, and wheezing.
How long does it take to get the ROS1 IHC test results?
Results are typically available within 5-7 days after sample receipt.
Is home collection available for the ROS1 IHC test?
Yes, DNA Labs India offers free home sample collection for the ROS1 IHC test across many cities in India.
What are the limitations of the ROS1 IHC test?
The test only detects ROS1 rearrangements, requires sufficient tumor tissue, and may not identify all variants.
How accurate is the ROS1 IHC test?
The ROS1 IHC test is highly accurate when performed on adequate samples, but confirmation with other methods like FISH may be recommended in some cases.
Can the ROS1 IHC test detect all ROS1 mutations?
No, the test primarily detects rearrangements and may not detect all point mutations or other variants.
What should I do if my ROS1 IHC test is positive?
Consult your oncologist to discuss targeted therapy options, such as ROS1 inhibitors, and develop a personalized treatment plan.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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