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RTN3 Gene Alzheimers Disease, RTN3 Related NGS Genetic Test

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RTN3 Gene Alzheimers Disease, RTN3 Related NGS Genetic Test

Short Name: RTN3 Alzheimer's NGS Test

Also known as: RTN3 Gene Alzheimer's Disease NGS, Alzheimer's Genetic Test RTN3, Reticulon-3 Gene Sequencing, RTN3 Risk Variant Analysis

RTN3 Gene Alzheimers Disease, RTN3 Related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available within 3 to 4 weeks from receipt of the sample.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to identify genetic variations in the RTN3 gene that may influence susceptibility to Alzheimer's disease. It is not a standalone diagnostic test but a tool for risk assessment, familial evaluation, and clinical correlation.

Test Code
3869
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are generally available within 3 to 4 weeks from receipt of the sample.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. Inform the lab about any recent blood transfusion or bone marrow transplant, as it may affect the genetic analysis.

Method: Peripheral venipuncture or finger-prick blood on FTA card

Step 2

Laboratory Analysis

A trained phlebotomist will draw a small amount of blood. If using an FTA card, a simple finger-prick blood spot will be collected.

Step 3

Report Delivery

There is no usual downtime; you can resume normal activities immediately.

Timeline: Reports are generally available within 3 to 4 weeks from receipt of the sample.

Patient Instructions

1
Before the Test:No fasting required. A genetic counseling session may be arranged to review family history and obtain informed consent.
2
During the Test:A blood sample is collected or an FTA card is spotted with blood. The sample is sent to the laboratory for NGS analysis.
3
After the Test:You will receive a comprehensive report with raw data files. It is recommended to schedule a follow-up consultation with the referring physician or genetic counselor to discuss the results.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to identify genetic variations in the RTN3 gene that may influence susceptibility to Alzheimer's disease. It is not a standalone diagnostic test but a tool for risk assessment, familial evaluation, and clinical correlation.

How to Prepare

  • No special preparation is needed.
  • Ensure the blood sample is collected in an EDTA vacutainer or applied to the FTA card as instructed.
  • Label the sample correctly with your name and date of birth.
  • Contact the lab for home collection if booked online.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing for late-onset Alzheimer's should always be paired with clinical evaluation and genetic counseling. A positive risk variant does not guarantee disease, and a negative result does not eliminate risk."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per laboratory requirement
ContainerEDTA vacutainer or FTA card
Collection MethodPeripheral venipuncture or finger-prick blood on FTA card

Sample Stability

Whole blood (EDTA): stable for 4-5 days at 2-8°C
FTA card: stable at room temperature for several weeks
Extracted DNA: stable for 1 year at -20°C if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Improperly labelled or unlabelled sample
  • Sample received in a breakable or unsuitable container
  • Insufficient quantity of blood or insufficient DNA concentration

Understanding Your Results

This test is designed for risk assessment. Results should be interpreted in the context of clinical history, cognitive testing, and other biomarker data. A clinical geneticist or neurologist should be consulted for accurate interpretation.
📊

Pathogenic or Likely Pathogenic variant detected

Indicates an increased risk for Alzheimer's disease; however, it is not a disease diagnosis. The magnitude of risk depends on family history and other factors.

📊

Variant of Uncertain Significance (VUS)

The variant is currently not well understood. Additional studies and family segregation analysis may be recommended.

📊

No clinically significant variants detected

No disease-associated variant was found in the RTN3 gene. This does not rule out Alzheimer's disease due to other genetic or environmental causes.

📊

Benign or Likely Benign variant

This is a normal genetic variation with no known impact on risk; it is reported for clarity but not actionable.

⚠️ When to Consult a Doctor:

If you have memory complaints or a first-degree relative with early-onset Alzheimer's dementia, schedule a consultation with a neurologist or a genetic counselor before ordering this test.

Limitations

  • ⚠This test evaluates only the RTN3 gene and does not screen for other Alzheimer's-associated genes such as APOE, PSEN1, PSEN2, or APP.
  • ⚠NGS may not reliably detect large structural rearrangements, copy number variants, or deep intronic mutations.
  • ⚠A negative test result does not exclude a diagnosis or future risk of Alzheimer's disease.
  • ⚠Genetic risk variants are probabilistic and not deterministic; environmental and lifestyle factors play a major role.

Risks & Considerations

  • ●Mild pain, bruising, or dizziness at the blood collection site
  • ●Psychological distress upon learning a higher genetic risk
  • ●No direct physical risks from the genetic test itself

Interfering Factors

  • ●Contamination of sample with foreign DNA
  • ●Poor quality or degraded DNA sample
  • ●Incomplete or missing clinical information
  • ●Concurrent use of immunotherapy or blood transfusion within the last 48 hours

Frequently Asked Questions

What is the RTN3 gene?
The RTN3 gene is located on chromosome 11 and encodes the reticulon-3 protein. This protein is involved in endoplasmic reticulum formation, protein processing, and calcium regulation within neurons.
How is the RTN3 gene linked to Alzheimer's disease?
Research has shown that variations in the RTN3 gene, especially the rs10498633 variant, are associated with an increased risk of developing Alzheimer's disease. Such changes may affect protein processing and calcium regulation in neurons, contributing to neuronal dysfunction.
What does the RTN3-related NGS genetic test do?
It analyses the DNA sequence of the RTN3 gene for mutations or variants, including the known risk variant rs10498633, using Next-Generation Sequencing (NGS). The result includes a variant classification report.
Who should consider this RTN3 gene NGS test?
This test may be considered for individuals with a family history of Alzheimer's disease, early-onset dementia, unexplained cognitive decline, or those who carry a known RTN3 variant in the family.
Do I need to fast before the test?
No, fasting is not required for this genetic test. You can eat and drink normally before sample collection.
What is the price of this test at DNA Labs India?
The special discounted price is Rs 20000.0, which includes a conclusive clinical report and raw data files (FASTQ, VCF, BAM).
How will I receive my test results?
You will receive the result via email and WhatsApp. The report can also be downloaded from the online patient portal. Raw data files are shared separately for transparency.
Are raw data files (FASTQ, VCF) shared with the report?
Yes. DNA Labs India is the only lab that shares Raw Data, FASTQ, and VCF files along with the conclusive clinical report. You should always ask for these files before ordering genetic testing.
What is the turnaround time for the RTN3 NGS test?
The report is generally available within 3 to 4 weeks after the sample reaches the laboratory.
Is genetic counseling required before testing?
Yes. A genetic counselling session is recommended to draw a pedigree chart of family members affected with Alzheimer's disease and to discuss the implications of the test result.
Does a positive result mean I will definitely get Alzheimer's disease?
No. A positive result indicates an increased genetic risk, not a guaranteed diagnosis. Many other genetic, environmental, and lifestyle factors are involved in disease onset.
Does this test detect all genetic causes of Alzheimer's?
No. This test specifically analyses the RTN3 gene. Other genes such as APOE, PSEN1, PSEN2, and APP are also associated with Alzheimer's and may be evaluated using broader panels.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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