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SCN10A Gene Episodic pain syndrome type 2, familial NGS Genetic Test

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SCN10A Gene Episodic pain syndrome type 2, familial NGS Genetic Test

Short Name: SCN10A EPF2 NGS Test

Also known as: SCN10A Gene Sequencing, EPF2 Genetic Test, Episodic Pain Syndrome Type 2 Panel

SCN10A Gene Episodic pain syndrome type 2, familial NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS (Next-Generation Sequencing)🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to detect pathogenic variants in the SCN10A gene that are associated with familial episodic pain syndrome type 2. It aids in confirmation of clinical diagnosis, identifies at-risk family members, and enables informed genetic counselling and management decisions.

Test Code
4096
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3-4 weeks from sample receipt.
Fasting Required
No
Method
Next Generation Sequencing
Step 1

Sample Collection

No specific preparation is required. Please provide a detailed clinical history, including symptoms and family pedigree, before sample collection.

Method: Blood draw

Step 2

Laboratory Analysis

A blood sample is collected from a vein or a saliva sample using a kit. For FTA card, a drop of blood is applied.

Step 3

Report Delivery

You may resume normal activities immediately.

Timeline: 3-4 weeks from sample receipt.

Patient Instructions

1
Before the Test:No special preparation. Ensure you have a physician's referral and clinical records.
2
During the Test:A blood sample is drawn by a phlebotomist. For FTA card, a finger-prick drop of blood is used.
3
After the Test:No restrictions. Resume normal activities.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to detect pathogenic variants in the SCN10A gene that are associated with familial episodic pain syndrome type 2. It aids in confirmation of clinical diagnosis, identifies at-risk family members, and enables informed genetic counselling and management decisions.

How to Prepare

  • Please carry any previous genetic test reports or clinical records.
  • Inform the laboratory about current medications, especially immunosuppressants.
  • Fasting is not required.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing confirms the diagnosis of familial episodic pain syndrome type 2. Early diagnosis can guide symptomatic management and provide reassurance."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume2-3 ml blood
ContainerEDTA tube
Collection MethodBlood draw

Sample Stability

Blood at room temperature: 72 hours
Blood at 2-8°C: 1 week
Extracted DNA: 1 month at -20°C
FTA card: 6 months at room temperature
Sample Rejection Criteria:
  • Haemolysed or clotted blood sample
  • Sample with incorrect labelling
  • Missing consent or clinical information

Understanding Your Results

The test result is interpreted by a clinical geneticist. A positive result confirms the clinical diagnosis of episodic pain syndrome type 2. A negative result reduces the likelihood of SCN10A-associated EPF2, but other genes should be considered.
📊

Pathogenic variant detected

Confirmed diagnosis of EPF2. Genetic counselling and family screening recommended.

📊

Variant of uncertain significance (VUS)

Cannot clarify diagnosis. Further family studies and functional assays are required.

📊

No pathogenic variant detected

Does not exclude EPF2. Consider testing other genes like SCN9A and SCN11A.

⚠️ When to Consult a Doctor:

If you or a relative experience recurrent unexplained pain episodes, consult a clinical geneticist or neurologist for evaluation and genetic testing.

Limitations

  • ⚠NGS may not detect all types of mutations such as large structural rearrangements or deep intronic variants.
  • ⚠Variants in regulatory regions are not routinely examined.
  • ⚠Test results must be interpreted by a qualified medical geneticist in the context of clinical and family history.

Risks & Considerations

  • ●Small risk of bruising or infection at the puncture site

Interfering Factors

  • ●Recent allogeneic bone marrow transplant
  • ●Contaminated or degraded DNA sample
  • ●Presence of haematological malignancy with clonal rearrangements

Frequently Asked Questions

What is the SCN10A gene?
The SCN10A gene provides instructions for making a sodium channel protein (Nav1.8) involved in pain signal transmission. Mutations in this gene are linked to episodic pain syndrome type 2.
What are the symptoms of episodic pain syndrome type 2?
Recurrent episodes of intense pain triggered by minor touching, pressure, temperature change, stress, or exercise. Episodes last minutes to hours and may be accompanied by sweating, flushing, or changes in heart rate.
How is EPF2 diagnosed?
Diagnosis is based on clinical history, family history, and confirmed by genetic testing using NGS analysis of the SCN10A gene.
What is the cost of the SCN10A NGS genetic test at DNA Labs India?
The SCN10A NGS genetic test costs INR 20,000 at DNA Labs India. Home sample collection is included, and the same price applies across major cities in India.
What type of sample is needed?
Blood, extracted DNA, or one drop of blood on an FTA card.
Do I need to fast before the test?
No, fasting is not required.
When will I get the report?
Reports are typically available within 3 to 4 weeks after sample submission.
Will insurance cover this test?
This test is not covered by insurance. You may need to pay out of pocket, but you can check with your insurance provider.
What does NGS technology mean?
Next-generation sequencing is a high-throughput method that rapidly sequences multiple genes or gene regions simultaneously, allowing comprehensive mutation analysis of the SCN10A gene.
Can this test detect all SCN10A mutations?
NGS detects single nucleotide variants and small insertions/deletions in coding regions. It may miss large rearrangements or deep intronic variants.
What is a VUS (Variant of Uncertain Significance)?
A VUS is a genetic change whose effect on health is not yet known. It requires further family testing and functional studies.
Why choose DNA Labs India for this test?
DNA Labs India is transparent and provides raw data, FASTQ, and VCF files along with the clinical report, enabling access to original data for further research or validation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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