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SCN11A Gene Episodic pain syndrome type 3, familial NGS Genetic Test

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SCN11A Gene Episodic pain syndrome type 3, familial NGS Genetic Test

Short Name: SCN11A Gene Test for FEPS3

Also known as: Familial Episodic Pain Syndrome Type 3, FEPS3, SCN11A-Related Pain Disorder

SCN11A Gene Episodic pain syndrome type 3, familial NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric to Adult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the SCN11A gene NGS genetic test is to identify mutations in the SCN11A gene associated with familial episodic pain syndrome type 3. This helps in confirming the diagnosis, differentiating from other pain disorders, guiding personalized treatment plans, and providing genetic counseling for family planning.

Test Code
1609
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Consult with a healthcare provider and provide clinical history. Ensure genetic counseling is scheduled if needed.

Method: Phlebotomy or Saliva Collection

Step 2

Laboratory Analysis

Sample collected via blood draw or saliva swab. For blood, a phlebotomist will collect in EDTA tube or on FTA card.

Step 3

Report Delivery

Sample is labeled and transported to the lab under controlled conditions. Avoid hemolysis.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Genetic counseling session to discuss family history and test implications. Provide clinical history of patient.
2
During the Test:Sample collection (blood or saliva) and analysis using NGS technology.
3
After the Test:Report generation in 3-4 weeks, followed by genetic counseling for result interpretation.

About This Test

Who Should Get This Test

The purpose of the SCN11A gene NGS genetic test is to identify mutations in the SCN11A gene associated with familial episodic pain syndrome type 3. This helps in confirming the diagnosis, differentiating from other pain disorders, guiding personalized treatment plans, and providing genetic counseling for family planning.

How to Prepare

  • Use sterile collection tubes
  • Label samples with patient details
  • Store at ambient temperature (15-30°C)
  • Transport to lab within 24 hours

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This genetic test is essential for confirming familial episodic pain syndrome type 3, enabling personalized pain management strategies and genetic counseling for families."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL blood or equivalent
ContainerEDTA tube or FTA card
Collection MethodPhlebotomy or Saliva Collection

Sample Stability

Stable at room temperature for up to 7 days
For FTA cards, stable for years if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Unlabeled or mismatched samples
  • Contaminated samples

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the SCN11A gene. Positive results confirm FEPS3, while negative results may not rule out other causes. Interpretation requires genetic counseling.
📊

Confirms diagnosis of familial episodic pain syndrome type 3. Recommend clinical management and genetic counseling.

📊

Suggests high likelihood of FEPS3. Clinical correlation and further testing may be needed.

📊

Variant not clearly linked to disease. Monitor and consider retesting with additional family data.

📊

FEPS3 unlikely due to SCN11A mutations. Consider other diagnoses or genetic tests.

⚠️ When to Consult a Doctor:

Consult a neurologist or genetic specialist if you experience recurring unexplained pain episodes, especially with a family history. Seek advice if test results are positive or uncertain.

Limitations

  • ⚠Does not detect all possible genetic variants (e.g., deep intronic mutations)
  • ⚠Results may require confirmation with Sanger sequencing
  • ⚠Genetic counseling is recommended for interpretation

Risks & Considerations

  • ●Minimal physical risks from blood draw (e.g., bruising)
  • ●Psychological impact of genetic diagnosis
  • ●Risk of misinterpretation without genetic counseling

Interfering Factors

  • ●Poor sample quality (e.g., hemolyzed blood)
  • ●Insufficient sample volume
  • ●Contamination during collection or storage

Frequently Asked Questions

What is SCN11A gene episodic pain syndrome type 3?
It is a rare genetic disorder caused by mutations in the SCN11A gene, leading to recurring episodes of severe pain in limbs or face, often triggered by movement or touch.
How is FEPS3 diagnosed?
Diagnosis involves clinical evaluation of symptoms and genetic testing using next-generation sequencing (NGS) to detect mutations in the SCN11A gene.
What are the symptoms of FEPS3?
Symptoms include severe, episodic pain in limbs or face, burning or shooting pain, numbness, tingling, sensitivity to temperature, and redness or swelling.
Who should get this genetic test?
Individuals with recurring unexplained pain episodes, especially with a family history of similar symptoms, should consider this test after consulting a healthcare provider.
What is the cost of the SCN11A gene test at DNA Labs India?
The test costs INR 20,000, which includes home sample collection across India.
How is the test performed?
The test uses next-generation sequencing (NGS) to analyze the entire SCN11A gene from a blood or saliva sample.
What sample is required for the test?
A small blood sample, extracted DNA, or one drop of blood on an FTA card is required.
How long does it take to get results?
Results are typically available in 3 to 4 weeks from the date of sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in many cities across India.
What does a positive test result mean?
A positive result confirms mutations in the SCN11A gene associated with FEPS3, guiding treatment and genetic counseling.
Are there any risks to the test?
Risks are minimal, such as bruising from blood draw. Genetic results may have psychological impacts, so counseling is advised.
What should I do before getting tested?
Consult a healthcare provider for genetic counseling, provide clinical history, and ensure sample collection instructions are followed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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