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SCN1B Gene Generalized epilepsy with febrile seizures plus type 1 NGS Genetic Test

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SCN1B Gene Generalized epilepsy with febrile seizures plus type 1 NGS Genetic Test

Short Name: SCN1B GEFS+ NGS Test

Also known as: GEFS+ Type 1, SCN1B-related Epilepsy, Febrile Seizures Plus Type 1

SCN1B Gene Generalized epilepsy with febrile seizures plus type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To diagnose Generalized Epilepsy with Febrile Seizures Plus Type 1 (GEFS+) by identifying mutations in the SCN1B gene, aiding in treatment planning, genetic counseling, and family risk assessment.

Test Code
1631
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

Genetic counseling session recommended. Provide clinical history and family pedigree.

Method: Venipuncture for blood; swab for saliva if specified

Step 2

Laboratory Analysis

Blood sample collected via venipuncture; alternatively, saliva sample if specified.

Step 3

Report Delivery

Sample transported to lab under stable conditions. Await report in 3-4 weeks.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consult with a geneticist or neurologist. Provide detailed medical and family history for pedigree analysis.
2
During the Test:Sample collection (blood or saliva) as per instructions. No special precautions needed during collection.
3
After the Test:Sample analyzed in lab using NGS. Report generated and delivered. Genetic counseling session for result interpretation.

About This Test

Who Should Get This Test

To diagnose Generalized Epilepsy with Febrile Seizures Plus Type 1 (GEFS+) by identifying mutations in the SCN1B gene, aiding in treatment planning, genetic counseling, and family risk assessment.

How to Prepare

  • Ensure proper patient identification
  • Use aseptic technique for blood collection
  • Label sample with patient details
  • Store sample at recommended temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of GEFS+ through SCN1B testing can guide treatment, improve seizure management, and facilitate genetic counseling for affected families. Genetic counseling is crucial before and after testing to understand implications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
ContainerEDTA Tube or FTA Card
Collection MethodVenipuncture for blood; swab for saliva if specified

Sample Stability

Blood: stable at room temperature for 24 hours
Extracted DNA: stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Sample improperly labeled
  • Insufficient volume
  • Hemolyzed or clotted blood

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the SCN1B gene. Positive results confirm GEFS+ diagnosis, while negative results may require further testing.
📊

Positive for pathogenic variant

Confirms diagnosis of GEFS+ Type 1. Genetic counseling and treatment planning advised.

📊

Negative for pathogenic variant

SCN1B-related GEFS+ unlikely. Consider other genetic or non-genetic causes of seizures.

📊

Variant of uncertain significance

Further testing and family studies recommended for clarification.

⚠️ When to Consult a Doctor:

If seizures persist, worsen, or if there is a family history of epilepsy. Consult a neurologist or geneticist for pre-test counseling and post-test interpretation.

Limitations

  • ⚠May not detect all possible mutations in the SCN1B gene
  • ⚠Does not rule out other genetic causes of epilepsy
  • ⚠Results require clinical correlation and genetic counseling

Risks & Considerations

  • ●Minor bruising at blood draw site
  • ●Rare infection risk
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Poor sample quality
  • ●Contaminated DNA extraction
  • ●Hemolyzed blood samples

Compare With Similar Tests

TestSCN1B Gene Generalized epilepsy with febrile seizures plus type 1 NGS Genetic TestSCN1A Gene GEFS+ NGS Genetic TestEEG (Electroencephalogram)MRI Brain
ComparisonSCN1B Gene Generalized epilepsy with febrile seizures plus type 1 NGS Genetic Test

Frequently Asked Questions

What is SCN1B Gene GEFS+ NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the SCN1B gene, associated with Generalized Epilepsy with Febrile Seizures Plus Type 1.
Who should take this test?
Individuals with a history of febrile seizures, epilepsy, or a family history of similar conditions should consider this test.
What is the cost of the test?
The test costs INR 20000, which includes sample collection, analysis, report, and genetic counseling.
How is the sample collected?
Blood or saliva sample is collected via venipuncture or swab, with free home collection available across India.
What is the turnaround time for results?
Results are typically delivered within 3 to 4 weeks after sample collection.
Is fasting required for this test?
No, fasting is not required for the SCN1B Gene GEFS+ NGS Genetic Test.
What does a positive result mean?
A positive result confirms the diagnosis of GEFS+ Type 1, guiding treatment and genetic counseling for the individual and family.
Can this test be performed on children?
Yes, the test is suitable for all ages, including infants and children with seizure history.
Is genetic counseling included with the test?
Yes, DNA Labs India includes a genetic counseling session to help interpret results and discuss implications.
What if the result is negative?
A negative result means SCN1B-related GEFS+ is unlikely, but further testing for other genes may be recommended.
How accurate is the NGS genetic test?
NGS is highly accurate for detecting genetic variants, but results should be correlated with clinical findings by a healthcare professional.
Where is this test available?
The test is available nationwide in India, with home sample collection in numerous cities including Mumbai, Delhi, Bangalore, and others.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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