Skip to main content
DNA Labs India

SCN3A Gene Epilepsy, focal, SCN3A related NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

SCN3A Gene Epilepsy, focal, SCN3A related NGS Genetic Test

Short Name: SCN3A NGS Test

Also known as: SCN3A Gene Sequencing, Nav1.3 Channelopathy Genetic Test, Focal Epilepsy NGS Genetic Test

SCN3A Gene Epilepsy, focal, SCN3A related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks after sample receipt. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify pathogenic variants in the SCN3A gene associated with focal epilepsy and related neurodevelopmental phenotypes. It helps confirm a clinical diagnosis, guide treatment decisions, assess prognosis and determine the risk of recurrence among family members.

Test Code
4074
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks after sample receipt
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation is required. A valid clinical history and pedigree chart may be needed. Genetic counselling may be performed before sample collection.

Method: Venipuncture or FTA card spot

Step 2

Laboratory Analysis

A trained phlebotomist will draw a blood sample or collect a few drops of blood on an FTA card. The procedure is quick and generally painless.

Step 3

Report Delivery

No specific precautions are required after sample collection. The patient may resume normal activities immediately.

Timeline: 3 to 4 Weeks after sample receipt

Patient Instructions

1
Before the Test:No special preparation is required. The patient's clinical history and family pedigree should be shared with the testing laboratory.
2
During the Test:The test involves a simple blood draw or FTA card blood spot collection. If using extracted DNA, a tissue sample may be sent by the hospital.
3
After the Test:No restrictions after the test. The patient can continue routine activities and medication as advised by the treating doctor.

About This Test

Who Should Get This Test

The purpose of this test is to identify pathogenic variants in the SCN3A gene associated with focal epilepsy and related neurodevelopmental phenotypes. It helps confirm a clinical diagnosis, guide treatment decisions, assess prognosis and determine the risk of recurrence among family members.

How to Prepare

  • Please provide the completed test requisition form with patient details
  • Ensure the sample is clearly labeled with patient name and unique ID
  • For blood sample, use an EDTA vacutainer
  • For FTA card, allow the blood spot to dry completely before packing

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for SCN3A-related epilepsy should be accompanied by genetic counselling. Family members at risk may benefit from predictive testing only after the clinical diagnosis is confirmed in the affected individual."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per laboratory protocol
ContainerEDTA vacutainer or FTA card
Collection MethodVenipuncture or FTA card spot

Sample Stability

Whole blood in EDTA vacutainer
Extracted DNA
FTA card blood spot
Sample Rejection Criteria:
  • Clotted or hemolyzed blood samples
  • Mislabeled samples with no patient identifier
  • Samples received without the clinical history or consent form
  • Improperly transported FTA cards with wet or contaminated spots

Understanding Your Results

Genetic test results should be interpreted by a qualified clinician or geneticist. Variants are classified according to international standards and reported with appropriate clinical significance.
📊

Pathogenic variant in SCN3A

Confirms the genetic diagnosis of SCN3A-related epilepsy in the appropriate clinical context.

📊

Likely pathogenic variant in SCN3A

Suggests that the variant is most likely disease-causing; family testing may be recommended.

📊

Variant of uncertain significance (VUS)

Indicates uncertain clinical impact; further testing of family members may help clarify.

📊

No pathogenic variant detected

Does not exclude SCN3A-related epilepsy, especially if other genetic causes are possible.

⚠️ When to Consult a Doctor:

If you or your child have recurrent seizures, unexplained focal epilepsy, developmental delay, speech difficulties, or a family history of SCN3A-related epilepsy, consult a neurologist or clinical geneticist for further evaluation.

Limitations

  • ⚠This test is focused only on the SCN3A gene and does not analyse other epilepsy-related genes
  • ⚠Negative result does not exclude a genetic cause of epilepsy
  • ⚠Rare non-coding variants or structural variants may not be detected by standard NGS
  • ⚠Clinical interpretation should always consider the full medical history and other investigation findings

Risks & Considerations

  • ●Mild pain or bruising at the blood collection site
  • ●Risk of variant of uncertain significance result
  • ●Potential psychological impact of genetic result
  • ●Unsure insurance coverage

Interfering Factors

  • ●Poor DNA quality or quantity may require repeat collection
  • ●NGS may not detect large deletions, duplications, or deep intronic variants
  • ●Variant of uncertain significance (VUS) may not give a definitive clinical diagnosis
  • ●Mosaic variants may not be reliably detected in low allele frequency

Compare With Similar Tests

TestSCN3A Gene Epilepsy, focal, SCN3A related NGS Genetic Test
ComparisonSCN3A Gene Epilepsy, focal, SCN3A related NGS Genetic Test

Frequently Asked Questions

What is SCN3A gene epilepsy?
SCN3A gene epilepsy is a rare form of epilepsy caused by mutations in the SCN3A gene. This gene provides instructions for making the Nav1.3 protein, which is important for normal nerve cell function. Mutations can disrupt brain nerve signaling and lead to recurrent seizures.
What are the symptoms of SCN3A-related epilepsy?
Symptoms can include recurrent seizures, focal seizures, behavioural changes, intellectual disability, speech difficulties, and muscle weakness. However, some individuals with SCN3A mutations may not develop epilepsy at all.
How is SCN3A gene epilepsy diagnosed?
Diagnosis involves a detailed medical history, neurological examination, EEG to measure brain activity, MRI to visualise the brain, and genetic testing to identify mutations in the SCN3A gene.
What is the cost of the SCN3A NGS genetic test in India?
The cost of the SCN3A related NGS genetic test at DNA Labs India is Rs 20000. The price includes free home sample collection in most major cities across India.
What type of sample is required for this test?
The test can be done using a blood sample, extracted DNA sample, or one drop of blood collected on an FTA card. The choice depends on the convenience of the patient and the lab protocol.
How long will it take to get the test report?
The report is usually available within 3 to 4 weeks after the sample is received by the laboratory.
Is fasting required before the test?
No, fasting is not required for this genetic test. The patient can eat normally before sample collection.
Is the SCN3A gene epilepsy test covered by insurance?
Genetic tests are often not covered by insurance in India. Patients may have to pay out of pocket. Some labs may offer payment plans or financial assistance.
Who should consider this genetic test?
People with unexplained focal epilepsy, recurrent seizures with neurodevelopmental issues, or a family history of SCN3A-related epilepsy should consider this test after consulting a neurologist or clinical geneticist.
What is the role of NGS in this test?
NGS, or Next Generation Sequencing, is a high-throughput technology that accurately reads the DNA sequence of the SCN3A gene. It helps detect mutations that may be responsible for epilepsy.
Can this test predict epilepsy in other family members?
If a disease-causing SCN3A variant is found in an affected family member, then close relatives can be tested for the same variant to determine their risk. This should be done with genetic counselling.
Should I ask for raw data files with my report?
Yes, it is advisable to ask for raw data files like FASTQ and VCF along with the clinical report. DNA Labs India provides these files for complete transparency, which allows for future reanalysis if needed.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Angelman Syndrome Test

₹10,000

Duchenne / Becker Muscular Dystrophy (DMD / BMD) Gene Mutation Test

₹14,000

Episodic Ataxia Type 1 Hotspot Test

₹11,500

Episodic Ataxia Comprehensive Profile Hotspot Test

₹16,000

Megalencephalic Leukoencephalopathy with Subcortical Cysts Van Der Knaap and Nalband MLC Gene Hotspot Mutation Test

₹7,500

Analyzer 18 SMA 18 Test Panel

₹1,755
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.