SCN9A Gene Neuropathy, hereditary sensory and autonomic type 2 NGS Genetic Test
Short Name: SCN9A HSAN2 NGS Genetic Test
Also known as: SCN9A Gene HSAN2 Test, Hereditary Sensory and Autonomic Neuropathy Type 2 Genetic Test, SCN9A Next-Generation Sequencing Test
SCN9A Gene Neuropathy, hereditary sensory and autonomic type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Once the sample reaches the DNA Labs India laboratory, the NGS workflow and analysis are completed and reports are delivered within 3 to 4 weeks.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify pathogenic variants in the SCN9A gene, confirm or exclude SCN9A-related hereditary sensory and autonomic neuropathy type 2, support family segregation testing, and guide personalized management and genetic counseling.
- Test Code
- 4435
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Once the sample reaches the DNA Labs India laboratory, the NGS workflow and analysis are completed and reports are delivered within 3 to 4 weeks.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No fasting is required. A genetic counseling session should be completed to draw a family pedigree and document clinical history. Bring any previous medical records, imaging, or prior genetic reports if available.
Method: Venipuncture / dried blood spot on FTA card / submission of extracted DNA
Laboratory Analysis
A trained phlebotomist will collect venous blood or prepare a dried blood spot on FTA card. If you are submitting extracted DNA, follow the laboratory instructions for handling and transport.
Report Delivery
No recovery time is needed. You can resume normal activities immediately. The sample will be transported to the laboratory for processing.
Timeline: Once the sample reaches the DNA Labs India laboratory, the NGS workflow and analysis are completed and reports are delivered within 3 to 4 weeks.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify pathogenic variants in the SCN9A gene, confirm or exclude SCN9A-related hereditary sensory and autonomic neuropathy type 2, support family segregation testing, and guide personalized management and genetic counseling.
How to Prepare
- No fasting is required for this genetic test.
- Use an EDTA tube for blood collection; do not use heparin.
- If using FTA card, apply one drop of blood and allow it to air dry before placing it in the protective pouch.
- If sending extracted DNA, label the tube clearly with patient details and keep the sample cold during transport.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing should always be accompanied by genetic counseling. The result must be interpreted in the context of the family pedigree, clinical presentation, and reproductive implications."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Frozen whole blood sample
- Heparinized sample
- Insufficient sample quantity or DNA concentration
- Mislabeled sample or missing requisition form
- Sample received in formalin or any non-approved container
Understanding Your Results
No pathogenic variant detected
Negative for SCN9A-related HSAN2. A negative result does not exclude all inherited neuropathies; broader genetic testing or clinical reassessment may be considered.
Pathogenic or likely pathogenic variant detected
Molecular diagnosis of SCN9A-related neuropathy is established. Genetic counseling and family member testing are strongly recommended.
Variant of uncertain significance (VUS) detected
A DNA change with unclear clinical significance is present. Additional family testing, segregation analysis, or functional studies may be required to clarify its role.
Consult a neurologist or medical geneticist if you or a family member have progressive numbness, painless injuries, recurrent foot ulcers, autonomic symptoms, or a known family history of hereditary sensory and autonomic neuropathy.
Limitations
- ⚠This targeted test analyzes the SCN9A gene; it does not rule out variants in other genes that can cause HSAN or related neuropathies.
- ⚠Standard NGS may not reliably detect large genomic rearrangements, deep intronic mutations, or repeat expansions.
- ⚠Variant of uncertain significance may require additional family studies or functional analysis.
- ⚠The timing and severity of symptoms can vary; genetic test results should be interpreted with clinical findings.
Risks & Considerations
- ●Minor pain, bruising, or bleeding at the blood collection site
- ●Anxiety related to genetic testing
- ●Identification of a variant of uncertain significance
- ●Possible psychological impact on the patient or family members
Interfering Factors
- ●Poor quality or degraded DNA
- ●Low DNA quantity
- ●Sample contamination during handling
- ●Sample mix-up or mislabeling
- ●Heparin contamination from improper blood collection
- ●Variants in deep intronic or regulatory regions not covered by the standard NGS assay
Compare With Similar Tests
| Test | SCN9A Gene Neuropathy, hereditary sensory and autonomic type 2 NGS Genetic Test | SCN9A Single-Gene NGS | HSAN / Neuropathy NGS Panel |
|---|---|---|---|
| Comparison | SCN9A Gene Neuropathy, hereditary sensory and autonomic type 2 NGS Genetic Test |
Frequently Asked Questions
What is the cost of the SCN9A HSAN2 NGS genetic test at DNA Labs India?
What sample is required for the SCN9A gene HSAN2 genetic test?
Do I need to fast before the SCN9A gene neuropathy test?
How long will the SCN9A NGS test report take?
What is hereditary sensory and autonomic neuropathy type 2 (HSAN2)?
What does NGS genetic testing for SCN9A include?
Will DNA Labs India provide raw data files with the report?
Can this test detect all genetic causes of HSAN2?
Is genetic counseling required before this test?
Can this test be used to screen at-risk family members?
Is home sample collection available for this test?
What are the possible results from this genetic test?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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