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SDHD Gene Mitochondrial complex II deficiency NGS Genetic Test

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SDHD Gene Mitochondrial complex II deficiency NGS Genetic Test

Short Name: SDHD Gene Mitochondrial Complex II Deficiency Test

Also known as: Mitochondrial Complex II Deficiency Genetic Test, SDHD Gene Mutation Analysis, Succinate Dehydrogenase Complex Subunit D Test

SDHD Gene Mitochondrial complex II deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the SDHD gene that cause mitochondrial complex II deficiency, aiding in accurate diagnosis, carrier testing, and genetic counseling.

Test Code
1726
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation required. Ensure proper identification and consent.

Method: Venipuncture or Finger prick for FTA Card

Step 2

Laboratory Analysis

Blood sample drawn by a trained phlebotomist. For FTA card, a drop of blood is applied.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Store sample as instructed.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:A genetic counseling session is recommended to understand the test implications and family history.
2
During the Test:Blood sample collection takes about 10-15 minutes by a trained professional.
3
After the Test:Results are available in 3-4 weeks. Follow-up counseling is advised for interpretation.

About This Test

Who Should Get This Test

To identify mutations in the SDHD gene that cause mitochondrial complex II deficiency, aiding in accurate diagnosis, carrier testing, and genetic counseling.

How to Prepare

  • Fasting not required
  • Bring valid ID and test requisition form
  • Inform about any medications or medical history

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early detection of SDHD gene mutations through NGS testing is crucial for managing mitochondrial complex II deficiency and informing family planning strategies."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5-10 mL of blood
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture or Finger prick for FTA Card

Sample Stability

Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the SDHD gene. A positive result confirms genetic predisposition to mitochondrial complex II deficiency.
📊

Positive for pathogenic mutation

Confirms diagnosis of SDHD-related mitochondrial complex II deficiency. Genetic counseling recommended.

📊

Negative

No pathogenic mutations detected. Symptoms may be due to other causes.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

If symptoms of mitochondrial disorders are present or if there is a family history, consult a geneticist or neurologist for evaluation and testing.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Cannot predict disease severity or onset
  • ⚠Results may require confirmation by other methods

Risks & Considerations

  • ●Minimal risk of bruising or infection at puncture site
  • ●Emotional impact of genetic results possible

Interfering Factors

  • ●DNA sample quality
  • ●Contamination during sample processing
  • ●Technical issues with sequencing

Compare With Similar Tests

TestSDHD Gene Mitochondrial complex II deficiency NGS Genetic TestSDHC Gene Mutation TestMitochondrial Genome SequencingFull Mitochondrial Complex II Panel
ComparisonSDHD Gene Mitochondrial complex II deficiency NGS Genetic TestTests for SDHC gene mutations in paraganglioma-pheochromocytoma syndrome.Analyzes mitochondrial DNA for various mitochondrial disorders.Includes multiple genes involved in complex II deficiency.

Frequently Asked Questions

What is SDHD Gene Mitochondrial Complex II Deficiency?
It is a rare genetic disorder caused by mutations in the SDHD gene, affecting the mitochondrial respiratory chain and cellular energy production.
How is the SDHD Gene NGS Genetic Test performed?
The test uses next-generation sequencing (NGS) to analyze the SDHD gene for mutations from a blood or DNA sample.
What are the common symptoms of this condition?
Symptoms include muscle weakness, fatigue, exercise intolerance, developmental delays, seizures, hearing loss, and vision problems.
Who should consider getting this test?
Individuals with symptoms of mitochondrial disorders, family history of SDHD mutations, or those undergoing genetic counseling.
What is the cost of the SDHD Gene NGS Genetic Test?
The test costs INR 20,000 at DNA Labs India, with free home collection across India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings in numerous cities.
How long does it take to get the test results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive test result mean?
A positive result indicates a pathogenic mutation in the SDHD gene, confirming genetic predisposition to mitochondrial complex II deficiency.
Can this test be used for carrier testing?
Yes, the test can identify carriers of SDHD gene mutations, useful for family planning.
How accurate is the NGS Genetic Test?
NGS is highly accurate and reliable for detecting gene mutations, providing detailed genetic insights.
Are there any risks associated with the test?
The test involves minimal risks such as bruising from blood draw. Emotional impact of results is possible.
How should I prepare for the test?
No special preparation is needed. A genetic counseling session is recommended to understand implications.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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