Semen FISH Test
Also known as: Sperm FISH, Fluorescent In Situ Hybridization on Sperm
Semen FISH Test test available at DNA Labs India for ₹8,190. Uses Fluorescent In Situ Hybridization (FISH) on Semen samples. Results in Results are typically available within 10-12 days after the sample is received by the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of Semen FISH is to determine if there is any increasing risk of chromosome malsegregation in sperm. It helps identify chromosomal abnormalities such as aneuploidy (e.g., trisomy, monosomy) that may lead to infertility, miscarriage, or genetic disorders in offspring. This information is crucial for couples considering assisted reproductive technologies (ART) and for genetic counseling.
- Test Code
- 6283
- CPT Code
- 88271
- ICD Code
- Z31.41
- Price
- ₹8,190
- Sample Type
- Semen
- Result Time
- Results are typically available within 10-12 days after the sample is received by the laboratory.
- Fasting Required
- No
- Method
- Fluorescent In Situ Hybridization (FISH)
Sample Collection
Abstain from ejaculation for 2-5 days before sample collection. Avoid alcohol, caffeine, and smoking for 24 hours. Inform your doctor about any medications or supplements you are taking.
Method: Masturbation
Laboratory Analysis
Sample is collected by masturbation into a sterile container. Avoid using lubricants or condoms as they may contain spermicidal agents. The sample should be kept at body temperature and delivered to the lab within 1 hour.
Report Delivery
No special precautions are needed after sample collection. You can resume normal activities immediately.
Timeline: Results are typically available within 10-12 days after the sample is received by the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of Semen FISH is to determine if there is any increasing risk of chromosome malsegregation in sperm. It helps identify chromosomal abnormalities such as aneuploidy (e.g., trisomy, monosomy) that may lead to infertility, miscarriage, or genetic disorders in offspring. This information is crucial for couples considering assisted reproductive technologies (ART) and for genetic counseling.
How to Prepare
- Abstain from ejaculation for 2-5 days
- Collect sample in a sterile container
- Avoid lubricants or condoms
- Deliver sample to lab within 1 hour
- Keep sample at body temperature during transport
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Semen FISH is a valuable tool for couples with recurrent implantation failure or unexplained infertility, as it provides critical information about sperm chromosomal integrity that standard semen analysis cannot."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not labeled correctly
- Sample collected in a non-sterile container
- Sample contaminated with urine or lubricants
- Sample not delivered within 1 hour
- Sample exposed to extreme temperatures
Understanding Your Results
Aneuploidy rate <5%
Low risk of chromosomal abnormalities in sperm; may proceed with standard fertility treatments.
Aneuploidy rate >5%
Increased risk of miscarriage or genetic disorders; consider ICSI with PGT-A.
Aneuploidy rate >10%
Significant risk; genetic counseling recommended; consider donor sperm or adoption.
Consult a fertility specialist if you have been trying to conceive for over a year without success, have a history of recurrent miscarriages, or have abnormal semen analysis results. Also, consult if you have risk factors such as advanced age, exposure to toxins, or family history of genetic disorders.
Limitations
- ⚠Semen FISH only evaluates specific chromosomes (13, 18, 21, X, Y) and not all chromosomes
- ⚠It does not detect structural abnormalities like translocations or deletions
- ⚠Results may not predict fertility outcomes with certainty
- ⚠Test requires a high-quality semen sample; low sperm count may limit analysis
Risks & Considerations
- ●No significant physical risks are associated with this test
- ●Psychological stress due to fertility concerns
- ●Possible discomfort during sample collection
Interfering Factors
- ●Recent ejaculation (within 48 hours) may affect sperm count
- ●Sample contamination with urine or lubricants
- ●Improper storage or transport of sample
- ●Recent illness or fever
- ●Medications that affect sperm production
Compare With Similar Tests
| Test | Semen FISH | Semen Analysis | Sperm DNA Fragmentation | Karyotype |
|---|---|---|---|---|
| Comparison | Semen FISH |
Frequently Asked Questions
What is Semen FISH test?
How much does Semen FISH cost in India?
Is fasting required for Semen FISH test?
What is the turnaround time for Semen FISH results?
What does Semen FISH detect?
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What is the difference between Semen FISH and Semen Analysis?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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