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SLC9A9 Gene Autism Susceptibility, Type 16 NGS Genetic Test

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SLC9A9 Gene Autism Susceptibility, Type 16 NGS Genetic Test

Short Name: SLC9A9 Autism Type 16 NGS Test

Also known as: SLC9A9 Gene Autism Susceptibility Type 16 Test, SLC9A9 Mutation Analysis, Autism Susceptibility Type 16 NGS Genetic Test

SLC9A9 Gene Autism Susceptibility, Type 16 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally delivered within 3 to 4 weeks from the date the sample is received at the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic TestAll age groups🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify SLC9A9 gene variants associated with increased susceptibility to autism spectrum disorder. The test is designed to support clinical diagnosis, family risk assessment, and management planning when autism symptoms are present.

Test Code
3916
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are generally delivered within 3 to 4 weeks from the date the sample is received at the laboratory.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting is required. It is recommended that the patient and family undergo a genetic counselling session to draw a pedigree chart and document the clinical history before sample collection. Please carry a doctor's prescription or referral if available.

Method: Peripheral blood draw or FTA card spot

Step 2

Laboratory Analysis

The blood sample is collected by a trained phlebotomist using a sterile blood collection kit. For FTA card sampling, a single drop of blood is applied to the FTA card. The process is quick and safe.

Step 3

Report Delivery

The sample is labelled, packed, and transported to the laboratory at ambient temperature. The patient can resume normal daily activities immediately after collection.

Timeline: Reports are generally delivered within 3 to 4 weeks from the date the sample is received at the laboratory.

Patient Instructions

1
Before the Test:No fasting is required. A genetic counselling session is recommended before the test to review family history, draw a pedigree chart, and discuss the implications of possible results.
2
During the Test:A blood sample is collected, or an FTA card spot/extracted DNA sample is provided. The process usually takes 5-10 minutes.
3
After the Test:The sample will be sent to the laboratory. Reports will be released within 3-4 weeks. A healthcare provider or genetic counsellor will help interpret the clinical significance.

About This Test

Who Should Get This Test

The purpose of this test is to identify SLC9A9 gene variants associated with increased susceptibility to autism spectrum disorder. The test is designed to support clinical diagnosis, family risk assessment, and management planning when autism symptoms are present.

How to Prepare

  • EDTA blood: Mix the blood gently and label the tube with patient ID and date.
  • Extracted DNA: Place DNA in a sterile screw-capped tube with a unique sample identifier.
  • FTA card: Apply a single blood spot, allow it to air dry completely, and store in the provided protective sleeve.
  • All samples must be accompanied by a requisition form with clinical history and consultation notes.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"SLC9A9 variants should be interpreted as risk factors rather than standalone diagnostic markers. A complete clinical evaluation, family pedigree, and genetic counselling are necessary before clinical decisions are made. This is especially important in prenatal and reproductive counselling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per laboratory protocol
ContainerEDTA vacutainer / sterile DNA tube / FTA card
Collection MethodPeripheral blood draw or FTA card spot

Sample Stability

FTA card blood spot: stable at room temperature for several weeks when stored dry.
Extracted DNA: stable at -20°C for long-term storage.
EDTA blood: transport to the laboratory as per kit instructions; do not freeze.
Sample Rejection Criteria:
  • Unlabelled or mislabelled samples.
  • Insufficient blood or DNA quantity.
  • Clotted or haemolysed blood affecting DNA quality.
  • FTA card with mixed or contaminated blood spots.
  • Missing clinical history or informed consent.

Understanding Your Results

Genetic test results should be interpreted by a clinical geneticist or a qualified specialist in conjunction with clinical features, family history, and other laboratory findings.
Pathogenic or likely pathogenic variant detected: indicates increased susceptibility for autism; referrals to clinical genetics, neurology, and developmental paediatrics are recommended.
No pathogenic variant detected: does not exclude autism or other genetic causes; additional genetic tests may be needed based on clinical features.
Variant of uncertain significance (VUS): not used as a diagnostic marker; additional familial segregation analysis may be helpful.
Benign or likely benign variant: considered normal population variation and not clinically actionable.
⚠️ When to Consult a Doctor:

Consult a qualified doctor if autism-like features are present, if the test result shows a pathogenic variant or VUS, or if you need help understanding recurrence risk and family planning options. A neurologist, paediatrician, psychiatrist, or clinical geneticist can provide further guidance.

Limitations

  • ⚠Targeted NGS analyzes SLC9A9 and selected autism-associated genes; it may not detect mutations in genes outside the targeted regions.
  • ⚠Standard NGS may not detect large deletions, duplications, structural variants, or repeat expansions.
  • ⚠A variant of uncertain significance may be reported and need additional family segregation studies.
  • ⚠A negative result does not exclude autism spectrum disorder or other genetic causes.

Risks & Considerations

  • ●Mild pain or bruising at the blood collection site.
  • ●Slight bleeding or haematoma.
  • ●Rare infection at the puncture site.
  • ●No radiation or significant physical risk from the genetic test itself.

Interfering Factors

  • ●Poor DNA quantity or quality.
  • ●Sample mix-up or labelling errors.
  • ●FTA card contamination or improper drying.
  • ●Incomplete clinical information.
  • ●Mosaic variants below the analytical sensitivity of NGS.
  • ●Novel variants where limited evidence is available for classification.

Frequently Asked Questions

What is the SLC9A9 gene?
The SLC9A9 gene is located on chromosome 3 and provides instructions for producing a sodium/hydrogen exchanger protein that helps regulate pH balance in cells. This protein is involved in the development and function of the brain and nervous system.
How is the SLC9A9 gene related to autism?
Variations in the SLC9A9 gene have been linked to increased risk for autism susceptibility. Such variations may alter the function of the protein, affect cellular pH balance in the brain, and influence neurodevelopment. Variants are considered risk factors and not a standalone cause.
What is the Type 16 NGS Genetic Test?
It is a next-generation sequencing test offered by DNA Labs India that analyzes DNA samples for variations in the SLC9A9 gene and other genes associated with autism susceptibility. It supports the diagnosis of symptoms and is used for risk stratification and recurrence risk counselling.
What sample is needed for this test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used. The sample should be collected by a trained professional under appropriate conditions.
What is the cost of the SLC9A9 Gene Autism Susceptibility Type 16 NGS Genetic Test?
The cost at DNA Labs India is INR 20,000, which includes sample collection, test analysis, and report. Free home sample collection is available for online bookings.
How long does it take to get reports?
Reports are generally issued within 3 to 4 weeks after the sample reaches the laboratory.
Is fasting required before this test?
No, this is a genetic test and fasting is not required. However, the clinical history and genetic counselling session should be completed before sample collection.
Is home sample collection available?
Yes. DNA Labs India offers free home sample collection for online bookings in many cities across India, including Mumbai, Delhi, Bangalore, Hyderabad, Chennai, Kolkata, and Pune.
What does a positive result mean?
A pathogenic or likely pathogenic variant indicates an increased susceptibility for autism spectrum disorder; it does not confirm autism alone. The finding must be interpreted in the context of clinical history and should be followed by genetic counselling. A negative result reduces but does not completely exclude genetic contribution.
Why should I ask for raw data files?
Raw data files such as FASTQ and VCF allow independent bioinformatics review, re-analysis, and future reinterpretation. DNA Labs India is transparent and provides raw data files along with the clinical report.
Who is this test meant for?
It is intended for individuals with features of autism spectrum disorder, delayed speech or language, social interaction difficulties, sensory issues, or a family history of autism or SLC9A9-related risk alleles. It should be ordered after a healthcare provider evaluation.
Does insurance cover this test?
Coverage depends on the payer, policy terms, and the clinical indication. Insurance schemes such as PMJAY, CGHS, ECHS, ESIC, and private insurers may or may not cover it. It is advisable to check with the respective scheme before testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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