SNCA Gene Dementia, Lewy body NGS Genetic Test
Short Name: SNCA Gene Lewy Body NGS Test
Also known as: Lewy Body Dementia Genetic Test, SNCA Gene Mutation Analysis, Alpha-synuclein Gene Sequencing, Dementia with Lewy Bodies NGS Panel
SNCA Gene Dementia, Lewy body NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are usually available within 3 to 4 weeks from sample receipt. Raw FASTQ and VCF files are shared along with the final interpreted clinical report.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this NGS-based genetic test is to detect pathogenic variants in the SNCA gene that are associated with dementia with Lewy bodies and related alpha-synucleinopathies. It supports a molecular diagnosis in patients with cognitive decline, parkinsonism, visual hallucinations, and autonomic dysfunction. Additionally, it may be used for family risk assessment after appropriate genetic counselling.
- Test Code
- 4006
- CPT Code
- N/A
- ICD Code
- G31.83
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are usually available within 3 to 4 weeks from sample receipt. Raw FASTQ and VCF files are shared along with the final interpreted clinical report.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. Please carry a doctor’s prescription, previous neurological reports, brain imaging records, and any available family history details. A genetic counselling session is recommended before undergoing this test.
Method: Venipuncture / Dried blood spot on FTA card
Laboratory Analysis
A small amount of blood will be collected by a trained phlebotomist. If using an FTA card, a single drop of blood may be collected by finger prick. The procedure is quick and usually takes only a few minutes.
Report Delivery
You can resume your normal activities immediately. If blood was drawn from a vein, press cotton over the puncture site for a few minutes to prevent bruising.
Timeline: Results are usually available within 3 to 4 weeks from sample receipt. Raw FASTQ and VCF files are shared along with the final interpreted clinical report.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this NGS-based genetic test is to detect pathogenic variants in the SNCA gene that are associated with dementia with Lewy bodies and related alpha-synucleinopathies. It supports a molecular diagnosis in patients with cognitive decline, parkinsonism, visual hallucinations, and autonomic dysfunction. Additionally, it may be used for family risk assessment after appropriate genetic counselling.
How to Prepare
- Inform the lab if you have had a blood transfusion or bone marrow transplant.
- For FTA card samples, allow the blood spot to dry completely before packing.
- Do not freeze FTA cards; store them in a dry protective sleeve.
- Ensure the sample tube is labelled with your correct name and patient ID.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Interpretation of an SNCA variant should always be combined with neurological examination, cognitive assessment, dopamine transporter imaging, and family pedigree analysis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted or hemolysed blood sample
- Insufficient sample volume
- Sample leaking or not properly labelled
- Sample received in an inappropriate container
Understanding Your Results
Pathogenic variant detected in SNCA gene
Supports a diagnosis of SNCA-related Lewy body dementia. Genetic counselling and family screening should be considered.
Variant of uncertain significance (VUS) detected
Cannot confirm or exclude SNCA-related dementia. Further familial segregation studies may help determine clinical significance.
No pathogenic variant detected
Does not exclude Lewy body dementia. Other genetic and non-genetic causes should be evaluated through clinical correlation.
If you or a family member experience progressive memory loss, fluctuating concentration, visual hallucinations, parkinsonism, sleep disorders, or have a known family history of Lewy body dementia, please consult a neurologist and genetic counsellor.
Limitations
- ⚠NGS may not detect all types of genetic changes such as large deletions, insertions, repeat expansions, or structural rearrangements
- ⚠A variant of uncertain significance may not provide a definitive diagnosis
- ⚠A negative result does not exclude Lewy body dementia, since other genetic and non-genetic causes may be responsible
- ⚠Predictive testing should only be performed with pre-test genetic counselling and informed consent
- ⚠This test is not a standalone diagnostic tool and must be interpreted alongside clinical, imaging, and laboratory findings
Risks & Considerations
- ●Minor bruising at the venipuncture site
- ●Dizziness or fainting during blood collection
- ●Small risk of local infection at the prick site
- ●Emotional distress from receiving genetic risk information
Interfering Factors
- ●Inadequate quantity or quality of extracted DNA
- ●Sample contamination or sample mix-up
- ●Recent allogeneic bone marrow transplant can affect germline genetic testing results
- ●Recent blood transfusion may rarely influence DNA analysis
Compare With Similar Tests
| Test | SNCA Gene Dementia, Lewy body NGS Genetic Test | ||
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| Comparison | SNCA Gene Dementia, Lewy body NGS Genetic Test |
Frequently Asked Questions
What is the cost of the SNCA gene / Lewy body NGS genetic test in India?
What does the SNCA gene test detect?
Do I need to fast before giving a blood sample?
What type of sample is accepted for this test?
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Does DNA Labs India provide home sample collection?
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Why should I ask for raw data and VCF files?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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