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SNCA Gene PARK4 Parkinson NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

SNCA Gene PARK4 Parkinson NGS Genetic Test

Short Name: SNCA PARK4 NGS Test

Also known as: SNCA Gene Test, PARK4 Genetic Test, Alpha-Synuclein Gene Test, Parkinson's Disease NGS Test

SNCA Gene PARK4 Parkinson NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from sample receipt. Delays may occur due to sample quality or technical issues.. Free home collection in 300+ cities across India.

NGS Genetic TestAdults🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the SNCA Gene PARK4 Parkinson NGS Genetic Test is to detect pathogenic mutations in the SNCA gene associated with PARK4 Parkinson's disease. This aids in confirming diagnosis, guiding treatment decisions, informing family risk assessment, and supporting genetic counseling. It is particularly valuable for individuals with a family history of Parkinson's disease or early-onset symptoms, enabling proactive healthcare planning.

Test Code
1777
CPT Code
81479
ICD Code
G20
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Results are typically available within 3 to 4 weeks from sample receipt. Delays may occur due to sample quality or technical issues.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Patient should provide informed consent and clinical history. Genetic counseling is recommended prior to testing to discuss implications, benefits, and risks.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

Blood sample will be collected via venipuncture or finger prick by a trained phlebotomist. For FTA card, a drop of blood is applied and dried.

Step 3

Report Delivery

Sample is transported to the lab under controlled conditions. Results are available in 3-4 weeks, with genetic counseling provided for interpretation.

Timeline: Results are typically available within 3 to 4 weeks from sample receipt. Delays may occur due to sample quality or technical issues.

Patient Instructions

1
Before the Test:Prior to the test, a genetic counseling session is recommended to discuss the purpose, benefits, risks, and implications of genetic testing. Provide detailed clinical and family history to the healthcare provider.
2
During the Test:The test involves a simple blood draw or finger prick. The procedure is minimally invasive and typically takes a few minutes. No special preparation is required, but fasting is not needed.
3
After the Test:After sample collection, results will be available in 3-4 weeks. A genetic counselor or healthcare provider will explain the results and next steps. Store raw data files (FASTQ, VCF) for future reference.

About This Test

Who Should Get This Test

The purpose of the SNCA Gene PARK4 Parkinson NGS Genetic Test is to detect pathogenic mutations in the SNCA gene associated with PARK4 Parkinson's disease. This aids in confirming diagnosis, guiding treatment decisions, informing family risk assessment, and supporting genetic counseling. It is particularly valuable for individuals with a family history of Parkinson's disease or early-onset symptoms, enabling proactive healthcare planning.

How to Prepare

  • Ensure patient is relaxed and hydrated for blood draw.
  • Use sterile equipment to avoid contamination.
  • Label samples correctly with patient details.
  • For FTA card, allow blood to dry completely before packaging.
  • Transport samples at ambient room temperature unless specified otherwise.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for PARK4 Parkinson's disease aids in early intervention and family planning counseling, especially for individuals with a family history of neurodegenerative disorders."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL blood or as required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Blood in EDTA tube: Stable for 48 hours at 2-8°C or 24 hours at room temperature.
Extracted DNA: Stable for several months at -20°C.
FTA card: Stable at room temperature for extended periods if stored properly.
Sample Rejection Criteria:
  • Hemolyzed, clotted, or insufficient sample volume.
  • Improperly labeled or contaminated samples.
  • Samples without proper consent or clinical information.
  • Degraded DNA indicated by quality control checks.

Understanding Your Results

Interpretation of the SNCA Gene PARK4 Parkinson NGS Genetic Test results requires careful consideration of genetic findings in the context of clinical presentation and family history. A positive result indicates the presence of a pathogenic mutation in the SNCA gene, which is associated with increased risk for PARK4 Parkinson's disease.
📊

Negative (No pathogenic variants detected)

No mutations in the SNCA gene were identified. This reduces the likelihood of PARK4 Parkinson's disease, but does not exclude other genetic or non-genetic causes of Parkinson's symptoms. Clinical correlation is essential.

Action: Consult with a neurologist for further evaluation if symptoms persist.

📊

Positive (Pathogenic variant detected)

A mutation in the SNCA gene was found, consistent with PARK4 Parkinson's disease. This supports a genetic diagnosis and may indicate autosomal dominant inheritance, affecting family members.

Action: Refer for genetic counseling to discuss implications, family testing, and management options. Involve neurology for treatment planning.

📊

Variant of Uncertain Significance (VUS)

A genetic variant was identified, but its clinical significance is unclear. It may not be causative of disease.

Action: Repeat testing in the future as scientific knowledge evolves. Genetic counseling recommended for family risk assessment.

⚠️ When to Consult a Doctor:

Consult a doctor if you experience symptoms of Parkinson's disease such as tremors, rigidity, slowness of movement, or balance problems. Additionally, seek genetic counseling if you have a family history of Parkinson's disease or receive a positive genetic test result. Early consultation with a neurologist or geneticist can guide appropriate diagnosis and management.

Limitations

  • ⚠This test only analyzes the SNCA gene; other genetic causes of Parkinson's disease are not evaluated.
  • ⚠Detects known pathogenic variants; novel or rare mutations may not be identified.
  • ⚠Cannot predict disease onset, progression, or severity with certainty.
  • ⚠Results should be correlated with clinical findings and family history.
  • ⚠Genetic testing is not a standalone diagnostic tool for Parkinson's disease.

Risks & Considerations

  • ●Minimal risk associated with blood draw, such as bruising, infection, or fainting.
  • ●Psychological impact of genetic results, including anxiety or distress; genetic counseling can mitigate this.
  • ●Potential for uncertain results (VUS), which may require further investigation.

Interfering Factors

  • ●Degraded or low-quality DNA sample
  • ●Hemolyzed blood samples
  • ●Contamination during sample collection or processing
  • ●Medications or treatments that may affect gene expression (consult with geneticist)

Frequently Asked Questions

What is the SNCA Gene PARK4 Parkinson NGS Genetic Test?
This test uses Next-Generation Sequencing (NGS) to analyze the SNCA gene for mutations associated with PARK4 Parkinson's disease, a rare genetic form of Parkinson's disease.
Who should consider this genetic test?
Individuals with a family history of Parkinson's disease, early-onset symptoms (before age 50), or those seeking genetic counseling for risk assessment should consider this test.
How is the test performed?
A blood sample or DNA is collected and analyzed using NGS technology to sequence the SNCA gene. The process is automated and highly accurate.
What are the symptoms of PARK4 Parkinson's disease?
Symptoms include tremors, rigidity, bradykinesia (slowness of movement), and postural instability, similar to other types of Parkinson's disease, but often with earlier onset.
Is genetic testing necessary for diagnosing Parkinson's disease?
Genetic testing is not mandatory but can be helpful for confirming hereditary forms like PARK4, guiding treatment, and informing family planning. Diagnosis typically involves clinical evaluation.
What does a positive test result mean?
A positive result indicates a pathogenic mutation in the SNCA gene, supporting a diagnosis of PARK4 Parkinson's disease and suggesting a genetic basis with potential family implications.
How accurate is this NGS genetic test?
NGS technology is highly accurate for detecting known mutations, with sensitivity and specificity over 99%. However, it may not identify all genetic variants or predict disease severity.
What is the cost of the test, and is it covered by insurance?
The test costs INR 20,000 in India. It is typically not covered by standard insurance plans, but specific schemes like PMJAY or CGHS may offer partial coverage; check with your provider.
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection across major cities in India for added convenience. Booking can be done online.
How long does it take to get the test results?
Results are usually available within 3 to 4 weeks after sample collection. You will receive them via online portal, email, or WhatsApp.
What should I do after receiving the test results?
Consult a genetic counselor or neurologist to interpret the results. They can guide management, family testing, and support options based on your findings.
Can this test predict if I will develop Parkinson's disease?
The test identifies genetic predisposition for PARK4 Parkinson's disease, but it cannot predict onset, progression, or certainty of disease development. Environmental and other factors also play a role.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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