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Spastic Paraplegia Panel NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

Spastic Paraplegia Panel NGS Genetic Test

Short Name: Spastic Paraplegia NGS Panel

Also known as: Hereditary Spastic Paraplegia Panel, HSP Gene Panel, HSP NGS Test

Spastic Paraplegia Panel NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS), Sanger sequencing confirmation for reported variants, Bioinformatic sequence analysis on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

This test is used to identify inherited genetic causes of hereditary spastic paraplegia in patients with suggestive clinical features such as progressive leg stiffness, gait disturbance and spasticity. The NGS-based panel enables simultaneous analysis of multiple genes associated with the disorder, helping clinicians confirm a diagnosis and guide genetic counselling, family screening and management.

Test Code
3857
ICD Code
G11.4
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS), Sanger sequencing confirmation for reported variants, Bioinformatic sequence analysis
Step 1

Sample Collection

No fasting is required. A genetic counselling session is recommended to draw a pedigree chart of family members affected with spastic paraplegia. Please carry prior neurological records if available.

Method: Peripheral venipuncture or FTA card blood spot

Step 2

Laboratory Analysis

The blood sample is collected by a trained phlebotomist. Alternatively, one drop of blood on an FTA card or an extracted DNA sample may be submitted.

Step 3

Report Delivery

No special precautions are needed after sample collection. You can resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:No special preparation is required. Complete a genetic counselling session and share relevant medical and family history with the testing team.
2
During the Test:The sample is collected by venipuncture or FTA card finger-prick blood spot by a trained phlebotomist.
3
After the Test:You can resume normal activities immediately. The lab will share the report within 3 to 4 weeks along with raw data files.

About This Test

Who Should Get This Test

This test is used to identify inherited genetic causes of hereditary spastic paraplegia in patients with suggestive clinical features such as progressive leg stiffness, gait disturbance and spasticity. The NGS-based panel enables simultaneous analysis of multiple genes associated with the disorder, helping clinicians confirm a diagnosis and guide genetic counselling, family screening and management.

How to Prepare

  • Genetic counselling must be completed before testing to document the family history
  • EDTA blood, extracted DNA or FTA card blood spot is acceptable
  • Clearly label the sample with patient name, date of birth and collection date
  • Free home sample collection is available for online bookings in select cities across India

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"A molecular confirmation is valuable in hereditary spastic paraplegia because the condition shares symptoms with other neurodegenerative disorders. The NGS panel should always be interpreted along with clinical examination, imaging findings and family history."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeWhole blood / extracted DNA / one FTA blood spot
ContainerEDTA vacutainer / DNA vial / FTA card
Collection MethodPeripheral venipuncture or FTA card blood spot

Sample Stability

EDTA blood sample should be transported to the laboratory at ambient room temperature
FTA card dried blood spots are convenient for transport at room temperature
Extracted DNA should be stored according to the laboratory transport kit instructions
Sample Rejection Criteria:
  • Clotted or hemolyzed blood samples
  • Insufficient sample quantity
  • Unlabelled or mislabelled samples
  • Empty FTA card without a visible blood spot
  • Sample received beyond the validated stability period

Understanding Your Results

Results should be interpreted by a medical geneticist, neurologist or referring physician in the context of the patient's clinical presentation and family history.
📊

Negative

No pathogenic or likely pathogenic variant was identified in the tested genes. This does not fully exclude hereditary spastic paraplegia; clinical correlation is necessary.

📊

Positive

A pathogenic or likely pathogenic variant was identified. This supports a molecular diagnosis of hereditary spastic paraplegia. Genetic counselling and family testing should be considered.

📊

Variant of Uncertain Significance (VUS)

A DNA change with unclear clinical significance was identified. Further familial segregation studies, updated reference databases or additional testing may be needed.

⚠️ When to Consult a Doctor:

If you or a family member have progressive stiffness or weakness in the legs, difficulty walking, spasticity, or a family history of hereditary spastic paraplegia, consult a neurologist or clinical geneticist for evaluation and genetic counselling.

Limitations

  • ⚠The panel may not include every gene associated with spastic paraplegia
  • ⚠Certain types of mutations such as deep intronic variants, large structural rearrangements or repeat expansions may not be detected by standard NGS
  • ⚠Variants of uncertain significance may be identified and require further testing
  • ⚠A negative result does not entirely exclude hereditary spastic paraplegia

Risks & Considerations

  • ●Minimal pain or discomfort at the blood draw site
  • ●Small bruise at the venipuncture site
  • ●Rarely, local bleeding or infection
  • ●FTA card sample collection involves only a finger-prick and has no needle risk

Interfering Factors

  • ●Poor quality or degraded DNA
  • ●Insufficient sample quantity
  • ●Contamination during sample collection
  • ●Bone marrow transplant recipients may show donor-derived DNA
  • ●Incomplete clinical or family history may affect interpretation

Compare With Similar Tests

TestSpastic Paraplegia Panel NGS Genetic Test
ComparisonSpastic Paraplegia Panel NGS Genetic Test

Frequently Asked Questions

What is the cost of the Spastic Paraplegia Panel NGS Genetic Test at DNA Labs India?
The test costs INR 20,000. This is a discounted all-inclusive price, and free home sample collection is available for online bookings across India.
What type of sample is required?
Blood or extracted DNA or one drop of blood on an FTA card is accepted. EDTA blood samples, DNA samples and FTA dried blood spots are all suitable for the test.
Do I need to fast before giving the sample?
No, fasting is not required for this genetic test. You can give the sample at any time of the day.
How long will it take to get the report?
Reports are typically issued within 3 to 4 weeks after the sample is received by the laboratory.
Is genetic counselling required before this test?
Clinical history of the patient is needed, and a genetic counselling session is recommended to draw a pedigree chart of family members affected with spastic paraplegia.
What is hereditary spastic paraplegia?
Spastic paraplegia is a group of hereditary neurological disorders that cause progressive stiffness and weakness in the lower limbs. It may also lead to difficulty walking, increased muscle tone and bladder or bowel dysfunction.
How does the NGS test confirm spastic paraplegia?
The test uses next-generation sequencing to analyse DNA for mutations in genes associated with spastic paraplegia. Detection of a pathogenic or likely pathogenic variant can support a clinical diagnosis.
Will I receive raw data with my report?
Yes, DNA Labs India provides raw data, FASTQ and VCF files along with the conclusive clinical report. You should ask for these files before testing; this is part of the transparency DNA Labs India offers.
Can this test be done for a child?
Yes, the test can be done at any age. However, a paediatric neurologist or clinical geneticist should guide the indication and interpretation for children.
Are there any risks related to the blood sample?
The risks are minimal and limited to the usual small discomfort or bruising at the venipuncture site. If an FTA blood spot is used, only a simple finger-prick sample is required.
What does a negative result mean?
A negative result means no pathogenic or likely pathogenic variant was detected in the analysed genes. It does not completely rule out hereditary spastic paraplegia because some disease-causing variants may not be included in the panel. Clinical correlation is essential.
Is this test covered by insurance?
Coverage depends on your insurance scheme and policy. It is not guaranteed under government schemes, so you should check with your insurer. DNA Labs India offers a transparent price of Rs 20,000.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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