SRGAP2 Gene Neuronal migration disorder NGS Genetic Test
Short Name: SRGAP2 NGS Genetic Test
Also known as: SRGAP2 Gene Sequencing Test, SRGAP2 Neuronal Migration Disorder NGS Test, SRGAP2 Gene Mutation Analysis
SRGAP2 Gene Neuronal migration disorder NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are generally available in 3 to 4 weeks after the sample reaches the laboratory. Raw data files, including FASTQ and VCF files, are shared along with the clinical report.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify disease-causing sequence variants in the SRGAP2 gene to support the clinical diagnosis of a SRGAP2-related neuronal migration disorder and provide accurate information for genetic counseling and family management.
- Test Code
- 4418
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are generally available in 3 to 4 weeks after the sample reaches the laboratory. Raw data files, including FASTQ and VCF files, are shared along with the clinical report.
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No fasting is required. The patient should carry a valid referral or clinical history. If the patient is already under the care of a neurologist or geneticist, prior investigation reports such as MRI or previous genetic tests should be shared with the laboratory.
Method: Peripheral blood draw or FTA card blood spot
Laboratory Analysis
A peripheral blood sample is collected by a trained phlebotomist, or a few drops of blood are collected on an FTA card as per the laboratory's protocol.
Report Delivery
No specific precautions are required after sample collection. The patient can resume normal diet and physical activities immediately.
Timeline: Reports are generally available in 3 to 4 weeks after the sample reaches the laboratory. Raw data files, including FASTQ and VCF files, are shared along with the clinical report.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify disease-causing sequence variants in the SRGAP2 gene to support the clinical diagnosis of a SRGAP2-related neuronal migration disorder and provide accurate information for genetic counseling and family management.
How to Prepare
- No special preparation such as fasting is needed.
- Please carry a government ID and the prescribed test requisition form.
- Inform the doctor if the patient has had a bone marrow transplant or blood transfusion recently.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This genetic test should be considered when a neuronal migration disorder is clinically suspected. Testing through NGS is best interpreted with pre-test genetic counseling and a three-generation family history."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted, hemolyzed, or visibly degraded blood sample
- Sample received in a plain tube without anticoagulant
- Incorrectly labeled or unlabeled sample
- Insufficient sample quantity for reliable DNA extraction
Understanding Your Results
Pathogenic or Likely Pathogenic Variant Identified
The test supports a molecular diagnosis of a SRGAP2-related neuronal migration disorder if the clinical picture is consistent. Family testing and recurrence risk counseling are recommended.
No Pathogenic/Likely Pathogenic Variant Identified
A negative result does not exclude a SRGAP2-related disorder. Other genetic causes or non-genetic causes should be considered by the treating clinician.
Variant of Uncertain Significance Identified
This result is not definitive. Additional testing of family members, segregation analysis, or a broader genetic work-up may be required to clarify its clinical significance.
Consult a neurologist or clinical geneticist if the patient presents with unexplained intellectual disability, epilepsy, developmental delay, autism spectrum disorder, speech delay, motor coordination difficulties, or neuroimaging features suggestive of a neuronal migration disorder.
Limitations
- ⚠This targeted test analyzes the SRGAP2 gene only and does not exclude variants in other neuronal migration-related genes.
- ⚠Large deletions, duplications, deep intronic variants, or structural rearrangements may not be detected by standard NGS analysis.
- ⚠A variant of uncertain significance may require additional family studies, functional evidence, or future reclassification.
- ⚠A negative result does not rule out all genetic causes of neuronal migration disorder.
Risks & Considerations
- ●Minimal risk of slight pain or bruising at the blood collection site
- ●Rare risk of bleeding in individuals with a bleeding disorder
- ●No specific radiation or pharmacological risks associated with this genetic test
Interfering Factors
- ●Poor DNA quality or low DNA quantity
- ●Sample contamination during collection or processing
- ●Recent haematological stem cell transplant or bone marrow transplant
- ●Incomplete clinical or family history that may limit variant interpretation
Compare With Similar Tests
| Test | SRGAP2 Gene Neuronal migration disorder NGS Genetic Test | Targeted SRGAP2 Gene NGS Test | Neuronal Migration Disorder Panel or Whole Exome Sequencing |
|---|---|---|---|
| Comparison | SRGAP2 Gene Neuronal migration disorder NGS Genetic Test |
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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