ST3GAL3 Gene Mental retardation, autosomal recessive type 12 NGS Genetic Test
Short Name: ST3GAL3 NGS Test
Also known as: ST3GAL3 Gene Sequencing, MRT12 Genetic Test, ST3GAL3 Mutation Analysis
ST3GAL3 Gene Mental retardation, autosomal recessive type 12 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks hours. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify pathogenic variants in the ST3GAL3 gene that cause autosomal recessive type 12 mental retardation. It is used to confirm a clinical diagnosis, provide prognostic information, guide management, and offer accurate genetic counseling for affected individuals and their families.
- Test Code
- 4253
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks hours
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation or fasting is required. A pre-test genetic counseling session is recommended to draw a pedigree chart and discuss the implications of results.
Method: Venipuncture or FTA card spot
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist. For FTA card samples, a few drops of blood are placed on the card and allowed to dry.
Report Delivery
There are no restrictions after sample collection. You can resume normal daily activities immediately.
About This Test
Who Should Get This Test
The purpose of this test is to identify pathogenic variants in the ST3GAL3 gene that cause autosomal recessive type 12 mental retardation. It is used to confirm a clinical diagnosis, provide prognostic information, guide management, and offer accurate genetic counseling for affected individuals and their families.
How to Prepare
- Blood sample in EDTA tube: 2-3 mL preferred
- FTA card: one drop of blood spot
- Extracted DNA: minimum 1 μg in sterile tube
- Label the sample with patient name, date, and time of collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing is crucial for accurate diagnosis and management of hereditary intellectual disabilities. This NGS test helps identify the underlying genetic cause, enabling informed family planning and personalized care."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Incorrectly labeled sample
- Sample not transported within stability timeframe
Understanding Your Results
No pathogenic variant detected
Negative result. ST3GAL3-associated MRT12 is unlikely; consider other genetic causes.
Pathogenic variant detected (homozygous or compound heterozygous)
Confirms the diagnosis of autosomal recessive type 12 mental retardation.
Variant of uncertain significance (VUS)
Cannot confirm diagnosis. Additional familial testing or functional studies may be recommended.
Consult a neurologist or clinical geneticist if you or your child experience unexplained intellectual disability, developmental delay, seizures, speech delay, or have a family history of autosomal recessive mental retardation.
Limitations
- ⚠NGS may not detect large deletions/duplications or trinucleotide repeat expansions
- ⚠A negative result does not exclude a genetic cause; further testing may be required
- ⚠Variants of uncertain significance may need familial segregation analysis
Risks & Considerations
- ●No significant physical risks are associated with blood collection. Slight pain or bruising may occur at the needle site.
Interfering Factors
- ●Rare benign variants may be reported as variants of uncertain significance
- ●Mutations in other genes can mimic MRT12 symptoms
Frequently Asked Questions
What is the cost of the ST3GAL3 gene NGS genetic test?
What sample is required for this test?
Is home sample collection available?
How long will the reports take?
What is Mental Retardation, Autosomal Recessive Type 12 (MRT12)?
Is this test diagnostic for MRT12?
Is fasting required before the test?
Who should consider this test?
Why choose DNA Labs India for this genetic test?
Will I get the raw data files along with the report?
Is genetic counseling included in this test?
Is this test covered by insurance?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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