STAC3 Gene Native American myopathy NGS Genetic Test
Short Name: STAC3 NGS Test
Also known as: STAC3 Gene Mutation Test, NAM Genetic Test, STAC3 Sequencing
STAC3 Gene Native American myopathy NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically delivered within 3 to 4 weeks after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify mutations in the STAC3 gene that cause Native American myopathy. It aids in confirming a clinical diagnosis, carrier detection, and prenatal testing in at-risk families. The test also helps differentiate NAM from other congenital myopathies with similar symptoms.
- Test Code
- 5861
- CPT Code
- 81408
- ICD Code
- G71.0
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Reports are typically delivered within 3 to 4 weeks after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. However, a clinical history and genetic counseling session is recommended before the test.
Method: Venipuncture or FTA card spot
Laboratory Analysis
Blood sample is collected by a trained phlebotomist using sterile technique. For FTA card, a few drops of blood are spotted on the card.
Report Delivery
No specific aftercare needed. The sample is transported to the laboratory at ambient temperature.
Timeline: Reports are typically delivered within 3 to 4 weeks after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the STAC3 gene that cause Native American myopathy. It aids in confirming a clinical diagnosis, carrier detection, and prenatal testing in at-risk families. The test also helps differentiate NAM from other congenital myopathies with similar symptoms.
How to Prepare
- Ensure the patient's identity is verified
- Use EDTA tube for blood collection
- If using FTA card, allow blood to dry completely before packaging
- Label the sample with patient details and date
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Genetic testing for STAC3 mutations is crucial for confirming Native American myopathy, guiding management and family counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood sample
- Incorrect labeling
- Sample received in improper container
- Sample exposed to extreme temperatures
Understanding Your Results
Positive
Pathogenic variant detected - confirms diagnosis of Native American myopathy
Action: Genetic counseling, management planning, family testing
Negative
No pathogenic variant detected - does not rule out NAM, other genes may be involved
Action: Consider broader gene panel or other diagnostic tests
Variant of Uncertain Significance
A genetic variant was found but its clinical significance is unknown
Action: Further segregation analysis or functional studies may be needed
Consult a geneticist or neurologist if you or your child have symptoms suggestive of Native American myopathy, such as muscle weakness, delayed motor milestones, or breathing difficulties. Also, if there is a family history of the condition, genetic counseling is advised.
Limitations
- ⚠This test does not detect large deletions/duplications or deep intronic variants
- ⚠Variant of uncertain significance may be reported, requiring further analysis
- ⚠Negative result does not exclude the possibility of mutations in other genes
- ⚠Genetic counseling is essential for result interpretation
Risks & Considerations
- ●Minimal risk of bruising or infection at the blood draw site
- ●Psychological impact of genetic results
- ●Potential for incidental findings
Interfering Factors
- ●Contaminated or degraded DNA sample
- ●Insufficient sample quantity
- ●Presence of maternal cell contamination in prenatal samples
- ●Rare polymorphisms that may complicate interpretation
Compare With Similar Tests
| Test | STAC3 Gene Native American myopathy NGS Genetic Test | Targeted STAC3 Mutation Analysis | Congenital Myopathy Panel | Whole Exome Sequencing |
|---|---|---|---|---|
| Comparison | STAC3 Gene Native American myopathy NGS Genetic Test |
Frequently Asked Questions
What is the cost of the STAC3 gene test at DNA Labs India?
What sample is required for this test?
Is fasting required before the test?
How long does it take to get the results?
Is home sample collection available?
What does the NGS test for STAC3 gene detect?
Who should consider this test?
Will the test detect all types of STAC3 mutations?
Is genetic counseling provided?
Can this test be done during pregnancy?
What is the accuracy of the NGS test?
Are there any risks associated with the test?
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